Research works

Mitigating the Impacts of Macro- and Microplastics on Marine Ecosystems: An Overview of Supporting Strategies and Cleanup Systems

In recent years, plastic litter in marine ecosystems has emerged as a global concern. Consequently, efforts to control, mitigate, and remove micro- and macroplastics from marine systems have intensified. In order to thoroughly analyze this topic, the present work provides a compr...

Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy

Calcific uremic arteriolopathy (CUA) is a rare, severe condition affecting patients with chronic kidney disease (CKD). The etiology of CUA is unclear. Here, we aimed to identify factors associated with its development. We reviewed the existing evidence on its pathomechanisms and...

When Treatment Leaves a Mark: Trifluoperazine-associated Hyperpigmentation in a Case Series

Abstract Drug-induced skin hyperpigmentation is a known but often overlooked side effect of phenothiazine antipsychotics. While chlorpromazine is commonly implicated, reports involving trifluoperazine are limited. Because psychiatric treatment is often long term and involves mult...

Community-Based Surgery and Postoperative Survival Among Veterans Affairs Enrollees

Importance: The Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks (VA MISSION) Act of 2018 greatly expanded Veterans Affairs (VA) enrollees' access to non-VA (community care) services. Since then, community-based utilization has increased...

Patient‐Reported Outcome Measures Following Pancreatectomy for Pancreatic Cancer: A Scoping Review

BACKGROUND: Patient-reported outcome measures (PROMs) are essential for evaluating quality of life in patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma (PDAC). This scoping review synthesises evidence on PROMs used in this population to guide future research...

Bacterial Community Dynamics and Ecological Characteristics in Temporary Holding Water of Live Seafood Tanks

Temporary holding water in live aquatic-product markets represents a short-term, animal-associated aquatic microenvironment, but its bacterial community dynamics remain poorly understood. In this study, 16S rRNA gene amplicon sequencing was used to characterize bacterial communit...

Sustainable Brake Pad Development: Integrating Micro- and Nano-Sized Ceramic Reinforcements and Carbon Nanotubes for Enhanced Tribological Performance

The development of sustainable, high-performance friction composites is critical for the automotive industry, given the environmental and health concerns associated with conventional brake pad materials such as asbestos and copper. This study investigates the effect of incorporat...

Application of machine learning and deep learning methods for the prediction of near misses and occupational accidents in the construction industry

Abstract Occupational accidents remain one of the key challenges for modern work systems, both from the perspective of employee health and life, and in terms of economic, social, and organisational losses for society. Despite the significant diagnostic value of near misses, data...

Closed‐Loop Solid‐State Synthesis Planning for Materials Discovery With Large Language Models

Developing reliable synthesis routes for complex materials remains a major bottleneck in accelerating materials discovery. This study establishes a large language model-based framework for predicting and optimizing synthesis conditions directly from the literature data. Key synth...

Multifunctional Diluent Enables High‐Voltage and Flame‐Retardant Potassium‐Ion Batteries

ABSTRACT Potassium‐ion batteries (PIBs) emerge as a highly promising candidate system in large‐scale energy storage, owing to their abundant resources, low cost, and potentially high operating voltage. However, the current development of PIBs still faces core bottlenecks such as...

Composite Hydrogel Loading Polysaccharides Derived from Coptis chinensis Franch. for Promoting Diabetic Wound Healing

Efficient treatment of diabetic wounds (DW) remains a major clinical challenge worldwide owing to vascular insufficiency, multiple bacterial infections, and overactivation of pro-inflammatory M1 macrophages caused by hyperglycemia. The development of novel pharmaceutical agents w...

Long-term treatment with sirolimus for pediatric vascular anomalies

Abstract Background Although sirolimus has emerged as a safe and effective treatment modality for unresectable vascular anomalies, comprehensive long-term follow-up data remain scarce in the current literature. This study aims to evaluate the long-term clinical experience of pedi...

Temporal Multi-Omics Reveals Microbial and Metabolic Succession Following Astilbin Treatment in a Human Colonic Model

Background: Astilbin is a bioactive flavonoid with documented anti-inflammatory properties; however, its sustained interactions with the gut microbiota remain poorly understood. Fecal samples from three healthy donors were pooled and fermented with astilbin in an in vitro human c...

Biomechanical responses to increased longitudinal bending stiffness differ between novice and experienced runner profiles

Carbon-plated footwear has primarily been developed and evaluated in trained or competitive runners. However, whether novice runners exhibit similar biomechanical responses to increased longitudinal bending stiffness (LBS) as experienced runners remains unclear. Therefore, the pu...

Prospects of green iron- and steelmaking via the FFC Cambridge process

The FFC Cambridge Process promises green iron-/steelmaking, where the respective metal oxides are used as the cathode in a molten electrolyte. Laboratory tests have validated the process at 500–900°C in molten chlorides, carbonates, fluorides or hydroxides. The reduction proceeds...

Quality Assessment in Frozen Seafood: Advances in Sensing Technologies and Artificial Intelligence

Frozen seafood plays an important role in the global food supply, but maintaining its quality during frozen storage and cold-chain distribution remains a significant challenge. Although freezing effectively slows microbial growth and enzymatic activity, it cannot completely preve...

Efficacy and tolerability of venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia – real-world analysis of Polish adult leukemia study group

We collected clinical data on 363 patients with relapsed/refractory chronic lymphocytic leukemia (RR-CLL) treated with venetoclax-rituximab (VR) in a real-world setting. The median age was 69.5 years (range, 32.5–91.6 years), and the median number of prior lines of therapy was 2...

The single cell transcriptional signature of sexual commitment in the human malaria parasite Plasmodium falciparum

<ns5:p> Background Malaria remains a global health challenge, with most fatal cases caused by <ns5:italic>Plasmodium falciparum</ns5:italic> in sub-Saharan Africa. A critical bottleneck in the <ns5:italic>Plasmodium</ns5:italic> life cycle is the transmission from human to mosqui...

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

ABSTRACT Myxoglucamides, natural products recently isolated from Cystobacterineae sp., are featured by an unprecedented vinyl‐substituted α‐keto‐γ‐amino acid that is linked to a glycosylated 14‐methyl‐pentadecanoic acid. Thus, they unite elements from three biomolecular classes i...

Efficacy and safety of repeated low-level red light therapy in myopia control: an updated and comprehensive systematic review and meta-analysis

This study aims to assess the therapeutic effectiveness and safety of repeated low-level red light for myopia management in children and adolescents. Multiple databases were systematically searched for studies evaluating the efficacy of RLRL in myopia control among children and a...