Research works

Trends and patterns of low birth weight and fetal macrosomia in a tertiary hospital, Northern Ethiopia, 2012–2021: multinomial modeling approach

Low birth weight (LBW) and fetal macrosomia represent critical extremes of the birth weight spectrum, posing substantial public health challenges in low- and middle-income countries. Although traditionally studied in isolation, these outcomes share underlying systemic factors tha...

The sequential occurrence of Bullous pemphigoid, membranous nephropathy and rheumatoid arthritis: all in one patient, a case report

Bullous pemphigoid (BP) is an autoimmune disease of the skin and mucous membranes. The presentation of BP as a multiple autoimmune syndrome has rarely been reported. We report a 49-year-old man with multiple blistering skin lesions and nephrotic syndrome. Skin-punch and kidney bi...

A study on the predictive value of preoperative MRI-based radiomics for postoperative neurological function in patients with ossification of the posterior longitudinal ligament

This study proposes to develop an integrative predictive model that synergistically combines quantitative radiomic features, established clinical risk parameters, and advanced machine learning methodologies to forecast postoperative neurological functional outcomes in patients di...

Engineered PEA-producing Lactobacillus paracasei F19 prevents colitis-associated colorectal cancer in mice by modulating inflammatory–angiogenic signaling and beneficially reshapes gut microbiota composition

Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-angiogenic properties...

Sustainable management of postharvest Fusarium rot in melon: A multi-target strategy based on bioactive extracts

This study evaluated the efficacy of various bioactive extracts (BEs) as sustainable alternatives to synthetic fungicides for controlling postharvest peduncular rot caused by Fusarium falciforme and F. sulawesiense in ‘Yellow’ melon ( Cucumis melo L.). Under in vitro conditions,...

Numerical modeling for generating ultrahigh porosity aluminum foam through independent control of pore size and cell wall thickness

This paper proposed a numerical modeling method for generating ultrahigh porosity aluminum foam through independent control of pore size and cell wall thickness. The proposed method introduced two independently adjustable parameters (point spacing and scaling distance) to control...

Beyond rewarming time: graft thermometry and cooling technologies in robot-assisted kidney transplantation—a scoping review

Robot-assisted kidney transplantation (RAKT) converts vascular anastomosis time into an incompletely measured thermal exposure. We mapped how grafts are cooled and how temperature is measured, reported, and linked to outcomes during RAKT. Following a prespecified protocol and a d...

Genetic characterization of suspected hereditary melanoma in a Central Italy cohort

Approximately 5–12% of cutaneous melanomas arise in a familial context, suggesting hereditary predisposition. Our analysis aims to investigate the clinical and genetic background of melanoma patients living in the Lazio area with a personal and/or family history of melanoma or ot...

Link-adaptive edge-cloud inference for UAV-based plastic mulch residue assessment

Plastic mulch residue assessment from UAV imagery is jointly constrained by segmentation accuracy, end-to-end latency and uplink bandwidth, since onboard inference loses boundary fidelity on fragmented film while cloud inference is throttled by the link, and these constraints hav...

Molecular investigation of Campula oblonga (Cobbold, 1858) reveals complex evolutionary history of parasites within the family Brachycladiidae (Odhner, 1905), parasites of wild cetaceans.

Speciation in parasites of marine mammals represents an important yet relatively understudied facet of marine research.Evolutionary and ecological interactions between the trematode family Brachycladiidae and their cetacean definitive hosts have previously been investigated at fa...

Association between heart rate, metoprolol use, and clinical outcomes in patients with heart failure and chronic obstructive pulmonary disease

Elevated heart rate is a recognized prognostic marker in heart failure (HF), and beta‑blockers are recommended to control heart rate. However, real-world data on discharge heart rate, beta-blocker dosing, and their prognostic associations in patients with concomitant HF and chron...

Exploring the attributes of organizational health literacy in Chinese healthcare institutions from the perspective of the social-ecological theoretical model: a grounded theory study

Organizational health literacy (OHL) is essential for reducing adverse outcomes associated with limited health literacy, including medication errors, increased hospitalization, and widening health disparities. Although the complexity of the healthcare system represents a major ba...

Perception of a communication workshop with patient partners by dental students: a qualitative study

Communication skills are vital for good patient-dentist relations. At Brest Dental University, a communication workshop for fourth-year undergraduate dental students involving role-playing with patient partners was devised and ran. The objective of this study was to explore perce...

The association between the availability of health guidance and self-management activities among patients with type 2 diabetes: a generalized linear mixed model incorporating patient- and GP-level factors

The availability of health guidance (AHG) provided by general practitioners (GPs) may vary in complex primary care settings. This study aimed to assess the AHG for patients with type 2 diabetes mellitus (T2DM) in general practice setting and examine the association between AHG an...

2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer

Active aldehydes are increasingly recognized as bioactive metabolites, but their roles in tumor immune regulation remain poorly defined. In colorectal cancer (CRC), prostaglandin metabolism contributes to immune suppression, whereas its upstream metabolic regulators are incomplet...

Enhancement of mechanical and antibacterial properties of glass ionomer cement using oyster shell-derived TiO2-hydroxyapatite nanorods for dental restoration application

Glass ionomer cement (GIC) is widely used in restorative dentistry due to its capability to form a chemical bond with tooth tissue and its biocompatibility. Nevertheless, its limited mechanical strength and antibacterial capabilities hinder its long-term success in dental restora...

Life satisfaction of socially active older adults aged 60–89: the role of health status, individual, and environmental factors

The aging population presents significant challenges for public health and social policy, particularly in the context of maintaining life satisfaction in later life. This study aimed to assess life satisfaction among socially active older adults aged 60–89 in Poland, with particu...

Salinity stress alleviation in maize using endophytic fungi isolated from desert trees: physiological and biochemical responses

Soil salinization is a critical global challenge that limits agricultural productivity, particularly in arid and semi-arid regions. Endophytic fungi from extreme desert habitats offer a sustainable biological strategy to enhance crop salinity tolerance; however, their mechanistic...

Changing trends in the clinical characteristics of gastrointestinal bleeding among hospitalized patients from 2012-2024 in China: a retrospective study

Gastrointestinal bleeding (GIB) remains a critical medical emergency with rising healthcare burdens in China. This study aimed to analyze its epidemiological shifts and risk factors over the past decade. A retrospective analysis included 3,523 inpatients with GIB at Renji Hospita...

Environmental sustainability in belt and road economies: quantile GMM STIRPAT evidence on the roles of trade, digitalization, renewable energy, innovation, urbanization, and human development

The stress on environmental systems of the involved economies has increased due to the fast rate of economic integration encouraged by the Belt and Road Initiative. The massive infrastructural spending, intensifying trade movement, and quickening urbanisation have simultaneously...