Research works

Heart rate control by listening to light

The auditory-cardiac interplay enables sound perception to modulate cardiac rhythm and homeostasis. However, its underlying regulatory mechanism and therapeutic potential remain largely underexplored, due to fundamental limitations in acoustic stimulation precision. Here we prese...

Interpretable multi-label prediction of institution-defined IgA nephropathy clinical patterns using routine cross-sectional clinical and laboratory data

IgA nephropathy (IgAN) clinical heterogeneity leads to inconsistent documentation of multiple, institution-specific pattern labels, creating an imbalanced multi-label phenotyping challenge. We developed an interpretable hybrid model, the Bidirectional Long Short-Term Memory-Convo...

Self-supervised graph attention networks for community-engaged lead contamination risk assessment

Lead contamination in residential water infrastructure poses a persistent public health risk, yet current assessment approaches rely on sparse homeowner sampling and tabular models that do not explicitly capture spatial dependencies in shared urban systems. Here we present a self...

Telerehabilitation compared with unsupervised home exercise for knee osteoarthritis: study protocol for a single-centre, parallel-group randomised controlled trial

Knee osteoarthritis (OA) is one of the leading causes of disability worldwide, with increasing prevalence and high societal and economic burden. Exercise-based rehabilitation is recommended as first-line management, yet adherence to unsupervised home exercise is often low. Telere...

Routine collection of patient reported outcomes in individuals with peripheral artery disease visiting a vascular specialty clinic: workflows, performance metrics, and clinical phenotypes

Patient-reported outcomes (PROs) in peripheral artery disease (PAD) provide valuable insights when assessing meaningful health status improvement after intervention. This study implemented routine PRO workflows in a large academic PAD practice to assess feasibility expressed as c...

The change process and implementation of the First-line Therapies model as experienced by nurses - a qualitative interview study

The First-line Therapies model is a national Finnish initiative designed to improve access to mental health services. It comprises a regionally adapted stepped approach to psychosocial treatment, digital tools to support treatment matching and needs assessment, and training for f...

Occult lung adenocarcinoma diagnosed by EBUS-TBNA after pneumothorax resolution in an RA-ILD patient with respiratory failure

RA-ILD is a serious complication of RA. Patients are prone to spontaneous pneumothorax and have a higher risk of lung cancer.Given poor lung function and high risk of pneumothorax recurrence, conventional biopsy is challenging, making diagnosis difficult. A 67-year-old male with...

Efficacy of 810 nm low-level laser therapy on muscle regeneration after bupivacaine-induced myonecrosis in a rabbit model

Skeletal muscle tissue has considerable regenerative capacity following injury; yet, this process may be gradual and constrained. Bupivacaine, a local anaesthetic, serves as a model for inducing muscle damage in experimental research. Low-level laser treatment (LLLT), also referr...

Additive manufacturing of advanced electronic devices: a comprehensive review of materials, processes, and applications

The additive manufacturing (AM) technology has gained recognition as an innovative technology that holds promise for transforming the electronics industry through the realization of complex designs and multi-material integration. Advances in additive manufacturing (AM) technologi...

Plant-derived exosome-like nanovesicles alleviate testicular injury by suppressing p21-mediated cell cycle arrest in Sertoli cells

Testicular dysfunction represents a leading cause of male infertility, yet effective therapeutic interventions remain elusive. Here, we report a novel plant-derived nanotherapeutic strategy for testicular injury using Cistanche deserticola -derived exosome-like nanovesicles (CDEL...

Comprehensive molecular characterization and biosafety assessment of TaDOF7.6 transgenic and gene-edited wheat

Wheat is one of the major staple food crops worldwide, and stable wheat yield is crucial for ensuring global food security. Transgenic and gene-editing technologies serve as important approaches for wheat genetic improvement, yet further application of related materials requires...

Diagnostic value of anti-carbamylated protein combined with Anti-RA33 antibodies in seronegative rheumatoid arthritis: a retrospective cohort study

Seronegative rheumatoid arthritis (SNRA), defined by the absence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), poses a persistent diagnostic challenge. Anti-carbamylated protein antibodies (Anti-CarP-IgG) and anti-RA33 antibodies targeting heterogene...

Beyond cholesterol: targeting ceramide signaling in cardiorenal metabolic crosstalk

Cardiovascular-Kidney-Metabolic (CKM) syndrome is associated with increased risks of cardiovascular mortality and target organ failure. Despite optimal lipid-lowering therapies, patients remain at substantial residual risk for adverse cardio-renal outcomes. Conventional cholester...

From predictive model to clinical application: interpretable prediction of metachronous liver metastasis in colorectal cancer

Metachronous liver metastasis (MLM) after curative surgery is a major determinant of poor prognosis in colorectal cancer (CRC), yet existing approaches based on clinicopathological indicators or imaging alone have limited predictive performance and clinical applicability. This re...

Comparative efficacy of irrigation activation systems in root canal cleanliness: a region-specific analysis of debris and smear layer removal

This study aimed to compare the efficacy of four irrigation activation systems against conventional needle irrigation (CNI) in removing debris and smear layer from root canal. Forty human single-rooted teeth premolars were instrumented to a consistent size and randomly divided in...

Seismic fragility analysis of multi-line transmission structure based on gas-insulated switchgear (GIS) equipment for nuclear power applications

The stable transmission of nuclear-generated electricity is vital for grid reliability and reactor external power supply. This study addresses this critical need by developing Finite Element Models (FEMs) of Gas-Insulated Switchgear (GIS) and a representative multi-line transmiss...

Beyond translation: a systems congruence framework for implementing type 2 diabetes guidelines in primary healthcare across Sub-Saharan Africa and Southeast Asia: a systematic review

Despite the availability of evidence-based clinical guidelines for type 2 diabetes mellitus (T2DM), their implementation in primary healthcare remains inconsistent across low- and middle-income countries (LMICs), particularly in Sub-Saharan Africa (SSA) and Southeast Asia (SEA)....

Prolonged exposure to atrazine through drinking water facilitates splenic apoptosis and induces exhaustion-like checkpoint upregulation in mice

Atrazine (ATR) is a widely used herbicide that persists in aquatic environments, raising concerns regarding its long-term immunotoxicity. As a central immune organ, the spleen represents a potential toxicological target, yet the impact of prolonged ATR ingestion via drinking wate...

Screen-detected health conditions among students in grade 1–9: findings from Timor-Leste’s first nationwide school-based screening program

Systematic health data on school-aged children in Timor-Leste have been lacking. The School-Based Primary Health Care Package screened students in Grade 1–9 nationwide in 2025. We describe the conditions detected and assess how far the estimates reflect variation between screener...

Professional identity and rural workforce commitment among regional quota medical students in Japan: a qualitative study

INTRODUCTION: Many countries use rural admission pathways and bonded scholarship programs to address persistent shortages of physicians in underserved areas. In Japan, the Chiiki-Waku (regional quota) system was established to recruit and train medical students who are expected t...