Research works

Blocking AGEs reduces airway epithelial viral susceptibility in diabetes-exacerbated COPD

Abstract Although diabetic complications are well-established in multiple organs, their impact on the respiratory system remains unclear. Clinical evidence indicates accelerated chronic obstructive pulmonary disease (COPD) progression in individuals with diabetes, yet the underly...

Pair distribution analysis of short- and medium-range order of metallic glasses: Direct imaging and diffraction-based approaches

Abstract Pair distribution function (PDF) analysis provides a quantitative framework for resolving short- and medium-range order in glasses. This article summarizes recent advances that extend PDF methods from bulk x-ray and neutron-diffraction methods to local electron microscop...

Clinicopathological analysis of distant metastasis in dermatofibrosarcoma protuberans: a report of 14 cases

BACKGROUND AND OBJECTIVES: Dermatofibrosarcoma protuberans (DFSP) is a rare sarcoma with a low metastatic rate; however, the prognosis worsens once distant metastasis occurs. We aimed to identify clinicopathological risk factors and molecular features associated with distant meta...

4000-year-old painted plaque from Southeast Indonesia reveals Austronesian Painting Tradition preceded Neolithic pottery

The Austronesian dispersal is the largest such event in human history, with descendants of people from Taiwan colonizing islands from Rapa Nui to Madagascar. The extent to which this dispersal was facilitated by an economic package or a particular ideology is uncertain. The “Aust...

The “migration industry” through the lens of the political economy of international migration in contemporary capitalism

Contemporary international migration is characterised by new infrastructures, institutions, agents and companies, with large multinational corporations playing a particularly prominent role. In partnership with leading imperialist powers, these corporations fulfil a strategic rol...

Evidence of a massive accretion event 1.8 billion years before the Gaia-Sausage-Enceladus merger

Abstract The merger history of the Galaxy has been traced back firmly to a redshift of 2 (10 billion years ago). While evidence for the existence of at least one more substantial merger before this time has been presented, its interpretation is yet to be fully established. Here w...

Randomized Quality Improvement Trials: An Overview and Proposed Framework for Ethical Oversight

Quality improvement (QI) is a routine part of health care delivery, but ineffective QI can have unintended consequences, waste resources, and paradoxically worsen health care quality. Randomized QI (RQI) trials use randomization to assign the QI intervention to some but not all p...

Another Type Inference Algorithm for First-Class Implicit Polymorphism

We propose yet another approach to type inference with first-class implicit polymorphism, based on the interleaving of an Algorithm M-style constraint-generating elaboration of terms and a solver for the generated constraints. The novelty of our approach is that types include exp...

A new standard for lyophilizer characterization, comparability and efficient technology transfers

This paper details the implementation of the ΔT and ΔP methodologies—recently introduced in the literature—for monitoring of mass flow during sublimation, demonstrating their application across multiple pharmaceutical companies. As a relatively new approach, this work is assessin...

Persistent Shelf‐to‐Basin Export of Bioavailable Dissolved Organic Carbon in the Arctic Ocean

Abstract Microbial carbon demand often exceeds local primary production in the oligotrophic central Arctic Ocean. Whether shelf‐derived dissolved organic carbon (DOC) provides a persistent carbon subsidy to reconcile this imbalance remains unclear. Here, we combine amino acid‐bas...

Correlation of MetalIon Coordination with MechanicalProperties and Ionic Conductivity in Homogeneous PEG-Based NetworkSolid Electrolytes

Abstract Understanding the relationship between metal ion coordination within polymer networks and macroscopic properties is a key factor in designing polymer electrolytes. In this study, homogeneous tetra/linear-PEG solid electrolytes were prepared by combining tetrafunctional a...

History of divergence and gene flow shaping geographic variation in Andean warblers (Myioborus).

Studying how genetic variation is structured across space, and how it relates to divergence in phenotypic traits relevant to reproductive isolation, is important for our understanding of the speciation process. We used ddRAD-seq data to examine genetic variation across the distri...

Brassinosteroid-regulated transcription factors confer epigenetic changes that repress plant immunity

Abstract When organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they often also incur trade-offs, such as reduced growth and development and must therefore be tightly controlled 1,2 . In this...

Altered thalamo–prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition

ABSTRACT Schizophrenia is associated with profound working memory deficits, for which there are no approved treatments. Rare heterozygous null mutations in SETD1A , a gene encoding a key epigenetic regulatory protein, have been definitively linked to increased risk for schizophre...

Insulin-Regulated Actin Dynamics is Disrupted in a Human Keratinocyte Model of Hailey Hailey Disease

Abstract Hailey Hailey Disease (HHD) is an autosomal dominant cutaneous disorder caused by mutations in ATP2C1 , the gene encoding the Golgi/secretory pathway Ca 2+ -ATPase SPCA1. Characterized by suprabasal acantholysis and intertriginous blistering of the skin, HHD treatment fo...

Wavelength Requirements for Life Detection via Reflected Light Spectroscopy of Rocky Exoplanets

Searching for signs of life is a primary goal of the Habitable Worlds Observatory (HWO). However, merely detecting oxygen, methane, or other widely discussed biosignatures is insufficient evidence for a biosphere. In parallel with biosignature detection, exoplanet life detection...

A framework for evidence-based psychotherapy with AI (EBP-AI).

Artificial intelligence (AI) systems and large language models (LLMs) offer substantial potential to augment or even fundamentally change elements of psychological assessment and treatment. However, current AI technologies have yet to demonstrate the capacity to effect meaningful...

Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT)

Abstract Live cells in tissue are plastic, phenotypically dynamic, and modify their function in response to genetic and environmental perturbations. To unleash the power of live-cell imaging to identify phenotype-genotype-function coupling over time, we report the development of...

Analyzing functional data with a mixture of covariance structures using a curve-based sampling scheme

Abstract Motivated by distinct walking patterns in real-world free-living gait data, this paper proposes an innovative curve-based sampling scheme for the analysis of functional data characterized by a mixture of covariance structures. Traditional approaches often fail to adequat...

Gaia’s Promise to Detect Compact-object Binaries: Where We Stand with the Third Data Release

Abstract With its third data release (DR3), Gaia begins unveiling dormant candidate compact object (CO) binaries with luminous companions (LC) as predicted by several past theoretical studies. To date, three black hole (BH), 21 neutron star (NS), and ≈3200 white dwarf (WD) candid...