Research works

Construction and cross-cohort evaluation of a shared metabolic reprogramming–related gene signature in esophageal and lung squamous cell carcinoma

We investigated directionally consistent metabolic alterations in esophageal squamous cell carcinoma (ESCC) and lung squamous cell carcinoma (LUSC) and developed a pooled prognostic risk score. TCGA and GTEx data were used to identify shared differentially expressed metabolic gen...

Improving neuropathological reconstruction fidelity via AI slice imputation

Neuropathological analyses benefit from spatially precise volumetric reconstructions that enhance anatomical delineation and improve morphometric accuracy. Prior work has shown the feasibility of reconstructing 3D brain volumes from 2D dissection photographs. However, these outpu...

Cool and warm conditions disrupt development through divergent mechanisms in larvae of the reef-building coral Orbicella faveolata

Developing animals are sensitive to stressful abiotic environmental conditions, which can induce negative effects including disrupted developmental progression and mortality. Plasticity in physiology and gene expression can protect developing organisms from stressors, yet how thi...

Association of sulfur microbial diet with lung cancer incidence and lung cancer-related mortality in 95,612 American adults: a prospective cohort study from the PLCO trial

The sulfur microbial diet (SMD) score is a microbiome-related dietary proxy derived from food groups associated with sulfur-metabolizing bacteria. Whether it is associated with lung cancer remains unclear. We analyzed 95,612 participants from the Prostate, Lung, Colorectal, and O...

Comparative phytochemical characterization and in vitro biological activities of coffee (Coffea arabica) and loquat (Eriobotrya japonica) seed extracts

The growing demand for natural bioactive compounds has intensified research into plant-derived extracts as plant-derived extracts as sources of bioactive compounds. Coffee ( Coffea arabica ) and loquat ( Eriobotrya japonica ) seeds represent underutilized sources of phytochemical...

Differential associations of aging attitude risk with depression, anxiety, and suicide-related risk among older Chinese adults: a network analysis and GGMNIRA-based simulated intervention study

Attitudes toward aging reflect how individuals understand and appraise their own aging process and may be closely associated with mental health in later life. Previous studies have primarily examined associations of attitudes toward aging with depression, anxiety, and suicide-rel...

Arbeidsintegrert læring i Norge: en studie av eksisterende forståelser og modeller i norsk UH-sektor

Artikkelen er en kvalitativ studie av åtte prorektorer for utdanning sin forståelse av arbeidsintegrert læring (AIL) samt beskrivelse av praksiser og modeller fra deres respektive organisasjoner. Disse innsiktene blir diskutert i lys av eksisterende modeller og forskning på AIL....

A case report of nephronophthisis type 1 (NPHP1) complicated with tethered cord in a pediatric patient: clinical phenotype and rapid progression to end stage renal disease

Nephronophthisis (NPHP) is an autosomal recessive cystic kidney disease and a leading cause of pediatric end stage renal disease (ESRD). Tethered cord is one of the important causes of neurogenic bladder in children, and the latter is a risk factor for secondary chronic kidney di...

Incidence of hepatic injury in term asphyxiated neonates admitted in three tertiary hospitals in Uganda: a prospective study

Birth asphyxia constitutes a major concern in the pediatric wards due to related increase in morbidity and mortality. Birth asphyxia related complications such as liver dysfunction, among others are well described in the literature, with the liver being at a high risk due to its...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Cross-cultural measurement of social overload and social networking sites exhaustion: Rasch and DIF evidence from Ghana, Hong Kong, Türkiye

Social media research increasingly examines the psychological costs of constant connectivity, yet the cross-cultural comparability of widely used social overload and Social Networking Sites (SNS) exhaustion measures remains insufficiently tested. This study examined the dimension...

Liquid metal enables compatible through-plane thermal transport and microwave absorption in flexible PDMS composite

Thermal interface materials combining high thermal conductivity with microwave-absorption capability are increasingly required for 5G communication modules, flexible electronics, and aerospace electronic systems, especially as chip sizes shrink and integration density increases....

Chaperone-mediated autophagy as a context-resolved proteostatic decision node in breast cancer

Therapy resistance, metastatic relapse, and immune evasion are major contributors to breast cancer–related mortality; however, the proteostatic systems that support phenotypic plasticity remain incompletely understood. Chaperone-mediated autophagy (CMA) is a selective lysosomal p...

Enhanced electrochemically-directed oligonucleotide synthesis via porous silica thin-film for DNA data storage

DNA-based data storage has emerged as a promising alternative for long-term information archiving and its implementation accelerates the development for on-chip large scale oligonucleotide synthesis. Among various technological routes, electrochemically directed synthesis offers...

Phytochemical screening as an inhibitor of β-lactamases to overcome the carbapenem-resistant of Klebsiella pneumoniae

The global emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a major health challenge due to its resistance to carbapenem antibiotics, such as imipenem and meropenem, primarily mediated by β-lactamases, including NDM and KPC carbapenemases. This study aimed to...

Scalable low-thermal-budget fabrication of suspended silicon nanowire devices

Silicon nanowires (Si NWs) are versatile one-dimensional building blocks for gas and biochemical sensors, MEMS/NEMS physical transduction platforms, and integrated electronic devices because of their high surface-to-volume ratios and compatibility with semiconductor processing. A...

Evaluating ensemble ranking fusion for multi-source localization in propagation graphs

Source identification in propagation graphs is an inverse problem that aims to recover the initial infected or activated nodes from an observed propagation snapshot. This paper studies a static, structure-driven setting in which temporal traces, observer timestamps, and large lab...

Comparative operative performance of three robotic platforms in benign gynecologic surgery: a single-surgeon retrospective cohort study

This single-surgeon retrospective cohort study compared operative efficiency and perioperative outcomes among the da Vinci Xi, Hugo RAS, and da Vinci SP platforms in 218 women undergoing robotic hysterectomy or myomectomy for benign disease. The primary outcome was console time;...

Shared household environment structures the gut microbiota in a large family cohort with central areolar choroidal dystrophy

Central areolar choroidal dystrophy (CACD) is a rare monogenic hereditary retinal dystrophy characterised by progressive retinal pigment epithelium and choriocapillaris atrophy, photoreceptor loss, oxidative stress, and chronic inflammation. Emerging evidence suggests that the gu...

Factors affecting the decline of intrinsic capacity of older adults in Chinese communities: a systematic review and meta-analysis

With the rapid aging of the global population, maintaining the intrinsic capacity of older adults has become a critical public health priority. However, the pooled prevalence of intrinsic capacity decline and its key determinants remain unclear. This study aims to assess the rate...