Research works

preSCRIPT: Large-scale prescription search and annotation engine for pharmacogenomic studies

Abstract Pharmacogenetics (PGx) has traditionally focused on a small number of high-impact variants affecting drug response due to the fact that PGx studies are labor-intensive and therefore low-throughput. Population biobanks linked to electronic health records (EHRs), including...

Intratumoral and peritumoral CT radiomics-clinical feature fusion model for differentiating pulmonary tuberculosis and pulmonary cryptococcosis nodules

Abstract Objective To investigate the clinical value of a fusion model combining intratumoral and peritumoral CT radiomics features with clinical features for differentiating pulmonary tuberculosis (PTB) from pulmonary cryptococcosis (PC) nodules, and to develop a predictive tool...

Proteomic reprogramming of ileal epithelial cells during homologous superimposed intestinal trematode infection reveals coordinated restoration of intestinal homeostasis

Abstract Background Intestinal helminth infections trigger complex host responses, determining parasite survival and tissue homeostasis. Primary Echinostoma caproni infection disrupts epithelial metabolism, differentiation, and repair in an IL-25-deficient environment, as shown i...

Interactions between hippocampus and visceral organs in sleep and wakefulness

Abstract Exteroception is attenuated during sleep, while interoceptive signals may remain active. If so, they can trigger responses in their target areas, including the hippocampus, which is known to receive information from the internal organs and is susceptible to oversynchroni...

Genome-wide identification and expression pattern analysis of the Medicago sativa 4-coumarate: CoA ligase (4CL) gene family

4-Coumarate: CoA ligase (4CL) is a pivotal enzyme in the phenylpropanoid metabolic pathway and plays a crucial role in plant growth, development, and stress responses. In this study, a genome-wide analysis was conducted to identify a total of 43 Ms4CL genes ( Ms4CLs ) in ‘Xinjian...

SRE Dynamics: User Guide and Interpretive Companion

This deposit contains the complete v1.6 manuscript suite for Status‑Relational Entropy (SRE) Dynamics, a foundational framework for information‑physical interconversion and mathematical reconstruction of observable universe. Important entry‑point instruction: File 7‑SRE_User_Guid...

A nonabelian Wilson surface on a lattice

A bstract We analyze the nonabelian surface holonomy on a bipartite hypercubic lattice following a proposal in arXiv:1002.4636 [hep-th]. The bipartite structure of the lattice enables us to introduce spike string configurations. These spikes play a crucial role for the time evolu...

On Gravitating Dyonic Configurations in Nonlinear Electrodynamics

We consider static, spherically symmetric configurations of nonlinear electromagnetic fields with Lagrangians $L(f)$, where $f = F_{μν} F^{μν}$, in general relativity (GR) and other metric theories of gravity. The corresponding exact solutions are well known in the framework of G...

EMBEDDING AUTHENTIC ASSESSMENT IN AR-BASED CIVIC EDUCATION

This study develops an empirically informed conceptual framework for embedding authentic assessment in AR-Based Civic Education integrated with Project Citizen across cognitive, affective, and participatory domains. The article reports a secondary design analysis embedded within...

Boundary Response Necessity: Divergent Resistance Near the Admissibility Boundary

This manuscript is H1 in the four-paper Hardening Series supporting the parent Displacement Framework for Horizon-Bounded Cosmological Accounting in a Timeless 4D Manifold (Partin, 2026). The parent paper establishes the admissible class, finite local capacity, continuity restric...

AKR7A3 rs1738023 association with susceptibility to female hepatocellular carcinoma and its role in AFB1 metabolism and tumor

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancer worldwide. In this study, we performed a two-stage exome-chip association analysis and found that the aldo-keto reductase family7 member A3 (AKR7A3) rs1738023 may be a potential susceptibility loc...

Cryogenic pure CsI as a probe for neutrino electromagnetic interactions

Abstract Searches for neutrino electromagnetic interactions at reactor sites require an unusual combination of ultra-low thresholds and a stable low-background environment. It is shown here that cryogenic undoped cesium iodide (CsI) naturally satisfies these conditions in a way p...

Differentiable Forward Modeling for Efficient and Accurate Shear Inference

Forthcoming Stage-IV dark energy optical surveys, such as LSST, have the ambitious goal of measuring cosmological parameters at sub-percent precision. Realizing their full scientific potential requires very precise measurement of the cosmic shear signal and control of correspondi...

NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment

Non-invasive preimplantation genetic testing (niPGT) using cell-free DNA (cfDNA) extracted from spent embryo culture medium (SECM) has shown great potential, providing economic and practical advantages for embryo ploidy testing and quality assessment, while minimizing the risk of...

Vacuum Property Decomposition from the ADM Plebański Factorisation: β and γ Separation, Shapiro Deflection Asymmetry, and Near-Horizon Vacuum Structure

The effective refractive index obtained from Plebański’s constitutive relations for the Schwarzschild metric in isotropic coordinates — here termed the Plebański index — encodes the gravitational vacuum’s optical response as a single scalar 𝑛(𝑟). The Arnowitt–Deser–Misner (ADM) d...

multiGMF: A multi-similarity geometric matrix factorization for identifying drug-associated indications

Abstract Drug repositioning serves as a promising strategy in drug development, exploring the potential uses of existing drugs through numerical computation. Compared to experimental screening, drug repositioning proves to be more efficient and cost-effective, playing a vital rol...

A nationally representative One Health multi-pathogen serosurvey in Cambodia: study protocol for the RACSMEI mixed-methods study

Abstract Background Cambodia faces a high and complex burden of zoonotic, vector-borne, vaccine-preventable and environmentally transmitted infections, driven by intensive human–animal–environment interactions. However, nationally representative data integrating human, animal and...

Between ‘old’ and ‘new’ sculpture: Thomas Woolner and the making of Victorian portrait sculpture

This article examines how Victorian sculptors conceived and contributed to the concept of the modern British hero through sculpture. It examines the conceptual, emotional and technical aspects of making a portrait sculpture, through a close analysis of Thomas Woolner’s recently p...

Redox-Dependent Lipophilicity of Phenazine Metabolites Is Modulated by Intramolecular Hydrogen Bonds and Controls Their Biological Distribution

Abstract Phenazines are redox-active microbial metabolites produced and secreted in diverse ecological contexts from soils to chronic infections. Phenazines can function variously as antibiotics, extracellular electron shuttles, and nutrient scavengers. Key to understanding the i...

Accelerated long-term forgetting as an objective marker of subjective memory impairment in multiple sclerosis

Abstract Background Accelerated long-term forgetting (ALF), defined as an increased rate of memory loss over extended intervals, has so far been detected in a pilot study of patients with mild multiple sclerosis (MS). This study aimed to (I) confirm the presence of ALF in a large...