Research works

Toward robust fine-scale decadal precipitation forecasts through dynamically consistent subsampling

Abstract. Reliable decadal predictions of regional precipitation are critical for managing water-resources and developing climate services, yet they remain a major challenge. To address this gap, we present a 5-step framework that integrates recent advances in decadal predictions...

Effect of electron cyclotron waves on plasma with runaway electrons

Abstract Runaway electrons generated during tokamak disruptions are a major concern for the safe operation of future fusion devices. The interaction of runaway electrons with waves has been proposed as a potential mechanism for their mitigation. This study investigates the effect...

Perceived difficulty accessing primary health care in a violence-affected community in the municipality of Rio de Janeiro, by sociodemographic characteristics and mental health status, 2024

Abstract Background: Barriers to access in Primary Health Care (PHC) can be exacerbated by contexts of social vulnerability and armed violence. This study analyzed perceived difficulty in accessing PHC according to sociodemographic characteristics and mental health conditions. Me...

Engineered hypoimmunogenic iPSC-derived mesenchymal stromal cells secreting high levels of functional FVIII ameliorate the hemophilia A phenotype

Background: Cell-based gene therapy represents a promising therapeutic avenue for genetic diseases such as hemophilia A (HA). However, clinical translation is limited by low transgene expression and host immune responses. Methods: Using CRISPR/Cas9, we targeted a codon-optimized...

LINC00152 is a lncRNA modulated by microenvironmental stimuli that has pathogenetic and clinical relevance in CLL

Abstract Chronic lymphocytic leukemia (CLL) is a common lymphoid neoplasm with heterogeneous biological features and clinical behavior, influenced by acquired genetic alterations and microenvironment interactions. We explored non-coding RNAs expression to understand their role in...

Dynamic topological exciton-polaritons enabling ultrafast logic operations

Topological active materials have emerged as a powerful paradigm bridging the discovery of exotic topological phases of matter with the development of functional topological devices. The recent extension of these material systems into dynamic regime, where topological properties...

An Early Documented Late-Spring Heatwave in Iberia Under Pre-Industrial Climatic Conditions

Early instrumental meteorological observations are essential for identifying and characterizing extreme climate events prior to the modern observational era, particularly in regions where historical data are scarce. This study documents a remarkable late-spring heatwave using new...

Polarity-aware knowledge graph reveals diet–microbiome–health mechanisms with relevance to muscle, immune and metabolic aging

Diet profoundly influences gut microbial composition and metabolism, yet mechanistic pathways linking dietary exposures to human health remain fragmented across the literature. To systematically organize and integrate this evidence, we constructed an evidence-weighted Diet-Microb...

KENOS - The Full Spectrum Operating Environment (Beta Live) with KAI Nexus Multiple Intelligence Orchestration Loop

This public-safe technical disclosure introduces KAI Nexus, the multi-intelligence orchestration layer within KAI (Kohenoor Artificial Intelligence) and the wider KENOS ecosystem. KAI Nexus is designed to coordinate heterogeneous AI models for advanced advisory workflows. At a hi...

Parameter estimation from amplitude collapse in correlated matter-wave interference

Operating matter-wave interferometers as quantum detectors for fundamental physics or inertial sensors with unprecedented accuracies relies on noise rejection, often implemented by correlating multiple sensors. They can be spatially separated (gradiometry or gravitational-wave de...

Web Monitoring as an Early Warning System: “Benadryl Challenge” Online Mentions Correlate With Diphenhydramine Overdoses Reported to US Poison Centers

PURPOSE: Social media has propagated several "challenges" that engage primarily adolescents in life-threatening behaviors such as the "Benadryl Challenge," where participants film themselves ingesting large doses of diphenhydramine. Once shared online, these activities have the p...

A Review of Collaborative Filtering Techniques in Recommender Systems

Collaborative filtering is one of the oldest and most widely used techniques in recommender systems. Instead of relying on item content, it leverages user behavior, such as ratings, clicks, or interaction histories, to predict user preferences. This paper reviews the main categor...

Degrees‐of‐Freedom Approximations for Conditional‐Mean Inference in Random‐Lot Stability Analysis

ABSTRACT Linear mixed models are widely used for pharmaceutical stability trending when sufficient lots are available. Expiry support is often based on whether lot‐specific conditional‐mean confidence limits remain within specification through a proposed expiry, and these limits...

Can UV meet IR in the Swiss cheese?

Abstract We consider the embedding of regular black holes in an expanding universe and study how the ultraviolet modifications to the Schwarzschild geometry that regularize the black hole singularity affect the exterior universe’s expansion rate. We consider several proposals for...

Use of single-item scales in the evaluation of German digital health applications (DiGAs): Scoping review protocol

Introduction German Digital Health Applications (DiGAs) are reimbursable, patient-facing digital interventions within the German healthcare system that must demonstrate positive healthcare effects. Outcome measurement in DiGA evaluations is influenced by both methodological consi...

Reconstruction of epithelial transcriptional trajectories reveals heterogeneous progression and early therapy-resistance programs in high-grade serous carcinoma precursors

Abstract Background Serous-tubal intraepithelial-carcinoma (STIC) is considered the principal precursor of tubo-ovarian high-grade serous-carcinoma (HGSC), yet its biological uniformity, progression risk and potential response to poly(ADP-ribose) polymerase-inhibitors (PARPi) rem...

Toward a Unified Theory of Understanding: A Conceptual Analysis for Natural and Artificial Understanding

Understanding is the foundational component of intelligence that makes adaptation to novel states possible. As artificial intelligence models advance toward artificial general and superintelligence, an objective, in contrast to human-centered, theory of understanding is required....

Psychological Inertia: A Dynamical Systems Framework for Pattern Persistence (Bridging to Predictive Processing)

This preprint develops Psychological Inertia as a dynamical systems framework for understanding why psychological patterns persist over time. It looks at persistence across cognition, emotion, behavior, motivation, and physiology. The framework argues that persistence reflects th...

Registration at the Limit of Recognition

This paper develops and extends a registrar-based theory of knowledge previously introduced in The Limits of Enumeration: A Registrar-Based Theory of Knowledge and Beyond Enumeration: Minimal Action and the Dynamics of Registration. In those works, knowledge was approached as an...

Sequential restriction of SNARE-mediated fusion by the COPII inner coat and SNARE chaperones

Abstract SNARE-mediated fusion requires assembly of four SNARE domains (R, Qa, Qb, and Qc) distributed across two membranes, with an SM (Sec1/Munc-18 family) chaperone catalyzing this assembly. We investigated topological requirements for the four SNAREs that mediate ER-Golgi fus...