Research works

Maternal microbiome promotes offspring ovarian reserve via bile acid metabolism

The maternal microbiome plays a crucial role in host ovarian function and fertility, yet its influence on in-utero ovarian development in offspring remains poorly understood. Here, we demonstrate that maternal antibiotic-induced microbiome disruption in mice leads to diminished o...

The 24-Cell Is a Gate Group: How the Binary Tetrahedral Structure Governs What a Qubit Can and Cannot See

The Watabe-Claude Method reads a signal's structure by assigning 4D-embeddedwindows to the 24 vertices of the 24-cell and decomposing the occupancy with thegroup B4. This note takes the 24-cell the other way -- into a qubit. Its 24vertices, as unit quaternions, are exactly the bi...

Comparative effectiveness of dietary supplements in dilated cardiomyopathy: a systematic review and network meta-analysis

Abstract Background Dilated cardiomyopathy (DCM) is a major cause of heart failure and cardiovascular mortality, partly due to impaired myocardial energy metabolism. Dietary supplements may offer benefits through improved mitochondrial function and antioxidant effects, and random...

Teaching Legal Theory in a Crowded (and Uncrowded) Curriculum

This article examines the challenges and opportunities of teaching legal theory, focusing on the dual dynamics of a curriculum that can feel both crowded and uncrowded. Here, ‘crowding’ refers not only to excess content and competing demands within the classroom, but also to the...

#RSAA2026 Identification of Key Hub Genes in Hepatocellular Carcinoma via Integrated Bioinformatics Analysis and Stringent PPI Network Filtering

Hepatocellular Carcinoma (HCC) remains one of the most aggressive malignancies with complex molecular mechanisms. This study aims to identify key hub genes involved in HCC progression through an integrated bioinformatics approach. The datasets were retrieved from the Gene Express...

Topology of Power: On the Recursive Blind Spots of Foucault and Nietzsche

This paper presents a topological and philosophical investigation into the structural limitations of Michel Foucault’s disciplinary power and Friedrich Nietzsche’s will-to-power as generative frameworks for understanding artificial intelligence. By introducing a Recursive Ontolog...

Superior hypogastric nerve block versus spinal anesthesia for early pain control after uterine fibroid embolization: a prospective quasi-randomized comparative study

PURPOSE: To compare early postprocedural pain and rescue opioid use after uterine fibroid embolization (UFE) in patients treated with superior hypogastric nerve block (SHNB) versus spinal anesthesia. MATERIALS AND METHODS: This single-center prospective quasi-randomized comparati...

Coherence Integrity for AI Systems II: Dynamic Alignment Through Four-Delusion Avoidance and Affective Engrams

This paper presents a conceptual framework for the safety of artificial general intelligence operating across extended periods of time. It argues that conventional safeguards based primarily on fixed rules, immutable model parameters, and output filtering cannot by themselves add...

Open-Source AI in Government: Procurement Barriers and Adoption Patterns in Public Sector

Research article: Open-Source AI in Government: Procurement Barriers and Adoption Patterns in Public Sector

Rebalancing mitochondrial dynamics restores succinate dehydrogenase activity and reduces succinate release in hepatocellular carcinoma

BACKGROUND: Dysregulated mitochondrial dynamics in cancer cells perturbs mitochondrial function and metabolism and promotes cancer progression. Its impacts on the electron transport chain, oxidative phosphorylation, redox balance, and glycolysis are well recognized. However, its...

A Human-Centric Deterministic-Kernel Probabilistic-Shell Architecture with Invariants that Confine Clinical AI Decision Authority

Medical artificial intelligence faces a structural tension: capability arises from probabilistic models, whereas safety requires guarantees those models cannot give. We implement and verify an architecture in which the probabilistic component holds no execution authority. A deter...

CPTu-Based Interpretation of Partially Drained Responses in Thickened and Conventional Mine Tailings

Abstract Cone penetration testing with pore-pressure measurements (CPTu) is used widely in tailings engineering, and most interpretation methods are formulated for fully drained or undrained responses. However, mine tailings often exhibit partially drained behavior, posing signif...

Emergent Spacetime from Self-Referential Computation: A Hierarchical Cellular Automaton Framework

This paper proposes a cosmological model — the Singularity-Bounded Holographic Class 4 Automaton (SB-HC4A) — derived from the convergence of four independently motivated frameworks: a five-class computational taxonomy that refines Wolfram's (2002) classification by separating fra...

Early-time sound field reconstruction from binaural room impulse responses and perceptual evaluation in auditory augmented reality

Abstract Realistic, coherent auditory augmented reality (AAR) requires virtual auditory illusions to be spatialised and acoustically matched to the local environment. To realise AAR, the early part of the sound field with the direct sound and early reflections are reconstructed f...

Topology of Power: On the Recursive Blind Spots of Foucault and Nietzsche

This paper presents a topological and philosophical investigation into the structural limitations of Michel Foucault’s disciplinary power and Friedrich Nietzsche’s will-to-power as generative frameworks for understanding artificial intelligence. By introducing a Recursive Ontolog...

Coherence Integrity for AI Systems II: Dynamic Alignment Through Four-Delusion Avoidance and Affective Engrams

This paper presents a conceptual framework for the safety of artificial general intelligence operating across extended periods of time. It argues that conventional safeguards based primarily on fixed rules, immutable model parameters, and output filtering cannot by themselves add...

Glucose-based fluid creep or maintenance fluids in critically ill adult patients: a scoping review of the available evidence related to blood glucose control

Abstract Background Fluid therapy is a fundamental aspect of intensive care unit treatment, encompassing resuscitation, maintenance, nutrition, and hidden fluid "creep" to keep lines open or dilute drugs. While most research has focused on resuscitation fluids, maintenance and fl...

Scoping review of the environmental conditions under which cold injuries occur: study protocol

Aim: to map the peer-reviewed literature on associations between meteorological conditions and cold injuries and the exposures studied. Research Question: What meteorological conditions have been investigated in relation to cold injuries and what associations have been reported w...

Non-invasive detection of obstructive sleep apnea from speech in a limited clinical dataset

Abstract This study investigates non-invasive detection of obstructive sleep apnea (OSA) from daytime speech in a limited polysomnography-labeled clinical cohort. The objective was to evaluate whether speaker-verification-inspired representations can support robust speech-based O...

Development and Validation of a Prediction Model for Alarm-Triggered Interventions in Pediatrics

BACKGROUND: Alarm fatigue in pediatric wards stems from frequent, nonactionable alarms that do not lead to clinical intervention. Predicting alarm-triggered clinical interventions is essential for optimizing monitoring strategies. OBJECTIVE: To identify factors associated with al...