Research works

Preclinical Evaluation of Combined Polo-like Kinase 1 Inhibition and Navitoclax in Experimental Models of Lung Cancer

Targeted therapies have substantially advanced cancer treatment; however, therapeutic resistance remains a major challenge, particularly in lung cancer. Polo-like kinase 1 (PLK-1), a key regulator of mitosis, is frequently overexpressed in lung tumors and has emerged as an attrac...

Beyond the binary: a patient-centred approach to SSRIs and pregnancy

Purpose This study aims to examine the polarised discourse surrounding selective serotonin reuptake inhibitor (SSRI) use during pregnancy and to propose a human rights-based and autonomy-focused approach grounded in reproductive justice and shared decision-making. Design/methodol...

Mental health knowledge-stigma profiles among primary healthcare workers involved in severe mental disorder management in Hainan, China

Under China’s Project 686 and the National Basic Public Health Service Program, primary healthcare workers play a central role in the community management of severe mental disorders. However, little is known about heterogeneity in mental health knowledge and perceived public stig...

Self-Care and Illness Perception in Inflammatory Bowel Disease: Identifying Adaptive and Maladaptive Profiles Through Person-Centered Analysis

Abstract Self-care and illness perception are key determinants of adaptation to inflammatory bowel disease (IBD), but their relationship may be heterogeneous and poorly captured by average-level associations. This multicenter cross-sectional study examined whether self-care behav...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Violence against journalists in Africa: A systematic review

This systematic review explores a decade of research (2013–2023) on violence against journalists in Africa, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Data were drawn from Scopus-indexed and other scholarly databases. A c...

Continuous FMD-Net: A Physics-Driven Algorithm-Unrolling Network with Spatio-Temporal Dual Sparsity for Adaptive Fault Diagnosis

Extracting and demodulating weak fault signatures from rotating machinery under heavy background noise remains a significant challenge. Conventional methods such as Feature Mode Decomposition (FMD) rely on manual parameter tuning and are highly susceptible to mode mixing. To addr...

Identifiability of Sequential LLM Rewriting Channels

A document produced by one language model may be rewritten by others beforeanyone sees it, so the observable text is the endpoint of a latent sequence ofstochastic transformations. Modelling each rewriting mechanism as a Markovkernel and a lineage as an ordered composition of ker...

Smart ports as governance infrastructures for social and environmental accountability in the sustainable blue economy

Abstract Digital transformation is increasingly reshaping maritime transport and port systems, yet its implications for sustainable blue economy governance remain insufficiently theorised. This paper develops the Visibility to Accountability Framework for Smart Port Governance (V...

SYSTEM EVOLUTION PROPOSALS (rlab #128) — E8 Intelligence Research

- Add a pipeline to parse sexagesimal numbers from cuneiform tablet transcriptions and auto-compare to E8 root vector projections. - Integrate the Gods-Clock timing algorithm as a reusable module in the sacred-geometry research swarm for testing any claimed celestial period. Auth...

Retired but not silent: the value of retrospective elite interviews in sensitive research contexts

Purpose This article examines whether interviewing retired elites can help overcome methodological challenges in politically sensitive research, drawing on empirical evidence from Malaysia. Design/methodology/approach The study draws on 35 in-depth interviews with senior Malaysia...

Compatibility of Type 304H Stainless Steel in Static Molten FLiBe for Inertial Confinement Fusion Reactors: Role of Impurities and Redox Control

Molten fluoride salts, such as FLiBe (LiF-BeF2), are promising candidates for tritium breeding and heat transfer in fusion reactors, but corrosion of structural materials remains a major challenge. This study investigates the corrosion behavior of austenitic stainless steel 304H...

Examining Motor Response Inhibition in Comorbid Trichotillomania and Attention‐Deficit/Hyperactivity Disorder

ABSTRACT Trichotillomania (TTM) has shown high rates of comorbidity with ADHD. While both disorders have been associated with some performance deficits on measures of motor response inhibition, findings on deficits in TTM have been mixed. Deficits previously found in TTM may be i...

Competition mechanisms of interfacial crack propagations in thermal barrier coatings

Abstract Cracking failure of thermal barrier coatings (TBCs) in advanced gas turbines under bending loads presents a persistent engineering challenge, particularly regarding how cracks compete and propagate through multilayer structures. This study addresses that challenge by con...

Generative Commons and Realization Conditions: Non-Rival Forms, Effective Access, and Standing

A language, a research practice, or a body of technique is used without being consumed, and it is also transformed by the using. Speakers coin words, shift meanings, and change conventions, so a linguistic commons at one time is partly the product of its participants at earlier t...

A Calibrated Building Energy Simulation-Driven Framework for Balancing Embodied and Operational Carbon in the Transition to Zero-Emission Buildings

Educational buildings account for approximately 17% of the building sector’s energy consumption, making them critical for zero-emission building (ZEB) strategies. With students spending over 50% of their time indoors, life-cycle carbon assessments and targeted retrofitting are es...

Wild honey (grayanotoxin) intoxication and its complex interaction with pre-existing co-morbidities, influencing presentation and outcome: a case series

Background Grayanotoxin-containing wild honey causes cholinomimetic activity through voltage-gated sodium channel activation and increases the excitability of cardiac and neuronal membranes, leading to cardiovascular and neuronal toxicity. Prior studies describe general-populatio...

Parenting under violence: comparing rural-urban coping and everyday peace strategies in Antioquia, Colombia

Caring practices are an area of growing interest in feminist debates on violence and are increasingly recognised as key strategies of everyday peacebuilding. Yet, among different caring strategies, parenting has rarely been analysed as a dimension of reproductive labour that is b...

An Action-Centric Zero Trust Maturity Model for Agentic AI Environments

Large language model–based agentic AI systems can independently interpret user goals, develop plans, and interact with external tools. These capabilities introduce security concerns that extend beyond traditional access control. However, existing Zero Trust Maturity Models, such...

Antas ng Paggamit at Pananaw sa Artipisyal na Intelehensiya ng mga Mag-aaral Sa Kolehiyo: Batayan sa Pagbuo ng Alituntunin para sa Responsableng Paggamit ng AI

Ang mabilis na paglaganap ng Artipisyal na Intelehensiya (AI) sa larangan ng edukasyon ay nagbukas ng iba't ibang oportunidad at kasabay nito ay nagbigay ng mga hamon kaugnay ng responsable at etikal na paggamit nito. Ang pananaliksik ay naglalayong matukoy ang antas at pananaw n...