Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
35513 work(s)
- Climate & EnvironmentOpen access
Efficient nitrogen management as a win-win strategy for air quality, health, and climate
Reactive nitrogen (Nr) management links climate policy, air quality and food production, yet its combined impacts remain poorly quantified. Here, we conduct ensemble simulations with two global climate models, Goddard Institute for Space Studies (GISS) and Community Earth System...
- Health & Medicine
HomocamptothecinPayloads with Enhanced Potency forAntibody-Drug Conjugates
Abstract Camptothecin derivatives, exemplified by DXd, are a dominant class of payloads for antibody-drug conjugates (ADCs). Herein, we describe the design and synthesis of H2, a novel homocamptothecin featuring a simplified hydroxybutyl structure that circumvents the complex ass...
- Health & MedicineOpen access
Immunosuppressed patients have a substantially increased risk for developing skin cancer. Therefore, it is mandatory that such patients are adequately informed and aware of skin cancer and their increased risk to modify their behavior. Numerous studies have evaluated the topic, b...
- Society & EconomicsOpen access
Legal artificial intelligence is commonly evaluated at the level of the answer, but consequential legal systems require a different object of governance: the continuing warrant for institutional reliance. A legal conclusion may have been well grounded when produced and yet become...
- Climate & EnvironmentOpen access
Sector Paper XXV — The δI Substrate and the Unified Recovery of All Physics
Sector Paper XXV delivers the full structural recovery of all major physics domains from the δI‑substrate, completing the emergence chain of UN Theory. Using only public‑safe correlation geometry, alignment‑mode structure, horizon dynamics, collapse‑energy operators, and ξ‑field...
- Biology
Objectives To comprehensively evaluate the efficacy and exercise prescription parameters of traditional Chinese exercises (TCEs) on health outcomes in patients with musculoskeletal disorders (MSDs) and rigorously assess the certainty of the evidence. Design Umbrella review. Data...
- Materials & EnergyOpen access
A ComputationalStudy on Type-I Sn Clathrateswith Inorganic and Organic Guests
Abstract Semiconducting clathrates are a class of inclusion compounds where monatomic cations or anions are encapsulated in a framework made mainly of Si, Ge, Sn, and Sb atoms. In this study, we use density functional theory (DFT) computations to investigate a series of type-I cl...
- Health & Medicine
A Therapeutic Greenhouse Model for School‐Based Health
ABSTRACT Background The Therapeutic Greenhouse Program, located at an elementary school in an underserved community, offers a sustainable and reproducible model for school‐based garden programming. Developed by a school‐based health center, the program integrates medical and beha...
- Health & MedicineOpen access
Anti-nephrolithiatic Activity of Acacetin in Ethylene Glycol-Induced Nephrolithiasis in Rats
Nephrolithiasis, commonly known as kidney stones, is a prevalent urological disorder characterized by the accumulation of crystalline deposits in the kidneys. This condition is linked to considerable morbidity owing to the accompanying colicky pain, the necessity for surgical int...
- Health & MedicineOpen access
Juvenile localised scleroderma (jLS) is a rare disease which impacts negatively on health-related quality of life (HRQoL). We aimed to undertake the cross-cultural adaptation and validation of a novel disease-specific HRQoL measure, the Localised Scleroderma Quality of Life Instr...
- Society & Economics
What does a territory tell? Co-constructing heritage through complex social values in inner contexts
Italian inner areas are increasingly affected by depopulation, demographic ageing, and territorial fragmentation. In these contexts, cultural heritage is frequently mobilised as a resource for local development and regeneration. While heritage studies have widely recognised that...
- Society & EconomicsOpen access
Abstract Global evidence shows a deterioration in the mental health of children and adolescents during the COVID-19 pandemic, raising questions about how mental health care, including psychotropic medication prescriptions, has adapted. However, it remains unclear how this deterio...
- BiologyOpen access
Abstract Osteoblast dysfunction and altered Wnt/β-catenin-dependent responses accompany bone-remodeling imbalance in rheumatic and degenerative joint disease. Rosavin and salidroside are constituents of Rhodiola rosea preparations used without prescription, and are always encount...
- Engineering & TechnologyOpen access
The ability of organic semiconductors to be mechanically flexible, adjustable in their electronic properties, solution processable, and biocompatible has led to their identification as key materials for Neuromorphic and Bioelectronic systems. This review summarizes the relationsh...
- Physics & SpaceOpen access
Preventative Germline Gene Editing via Biomimetic Soft-Robotic Delivery Prior to Puberty
This concept paper presents a preventative, early-stage approach targeting reproductive stem cells (Spermatogonial Stem Cells/Oogonia) prior to puberty to mitigate monogenic neurodevelopmental traits. The framework integrates targeted lipid nanoparticles (LNPs) carrying base edit...
- Physics & SpaceOpen access
We propose a theoretical framework in which gravitation is represented fundamentally by an Evolution current propagating through an invariant, stationary nodal lattice rather than by a literal inward motion of space. The framework is motivated by the Painlevé–Gullstrand (PG) repr...
- Health & Medicine
Navigating Voriconazole in Pediatrics: Dosing Dilemmas and Monitoring Madness
ABSTRACT Safe and effective use of voriconazole in children necessitates therapeutic drug monitoring (TDM) of serum concentrations given the pharmacokinetic variability amongst these patients. Informed by an internal review of voriconazole TDM practices revealing suboptimal perfo...
- Physics & SpaceOpen access
Definition 1. A physical sphere is a sphere which an object emits.
- AI & ComputingOpen access
FINDING: DARPA's expMath program aims to use AI to discover new mathematical structures and proofs, potentially accelerating the identification of deep symmetries and invariants. | MATH: No explicit equations or constants provided in the search results; the focus is on programmat...
- Society & EconomicsOpen access
A manufatura aditiva por extrusão de material tem sido investigada como rota para a fabricação de formas farmacêuticas personalizadas, nas quais dose, geometria e perfil de liberação podem ser ajustados às necessidades de diferentes pacientes. As abordagens predominantes empregam...