Research works

Mechanistic study on the regulation of hepatocellular carcinoma progression by GNAI2 possibly through the PI3K/AKT pathway

Hepatocellular carcinoma (HCC), the most common form of liver cancer, remains poorly understood in terms of its underlying mechanisms. The protein GNAI2 has been shown to regulate the transcription of multiple biomolecules and is thought to contribute to the onset and progression...

Quantum Cosmic Heredity (QCH): A Non-Singular Bimetric Bounce Framework for Early Galaxy Formation and Cosmological Continuity

🌌 Quantum Cosmic Heredity (QCH) — Release v2.0.3 Version 2.0.3 represents a complete structural, mathematical, and observational audit of the Quantum Cosmic Heredity (QCH) manuscript. This release formalizes the unification of astrophysical black holes as sub-critical Child Grav...

Protomaton-Holographic Transcription Cosmology (PHTC): A Unified Model from Superconductivity to Cosmic Scales (Version 2— Extended and Revised Edition)

This is the third version (v3) of the PHTC model. This version supersedes all previous versions and incorporates the full theoretical framework, unified action, nonlinear response,rigorous low-energy degeneration proofs, 20+ testable predictions, and direct experimental corrobora...

Benchmark Brown Dwarfs as Chemical Laboratories: Linking System Bulk Properties to Atmospheric Retrievals

Abstract We present the first atmospheric retrieval analysis of two compositional benchmark mid-L dwarfs – SDSSJ141659.78+500626.4 and GJ 499 C – using the Brewster retrieval framework, where the wide benchmark nature of these systems provides independent constraints on age and b...

Formation of Accretion Disks around Intermediate-Mass Black Holes in Ultra Compact Dwarf Galaxies and Nuclear Stellar Clusters

Abstract Recent observations have found many ultra-compact dwarf galaxies (UCDs) that contain massive black holes (MBHs) typically consisting of 10% − 15% of their total mass, with some as high as 40%. However, whether UCDs initially started with MBHs or grew from intermediate-ma...

Development and genome-level microevolution of peri-implant microbiome during surface colonization

The peri-implant microbiome is closely associated with dental implant health and disease, yet its development and genome-level dynamics remain insufficiently understood. In this longitudinal cohort, we performed shotgun metagenomics on 95 subgingival plaque samples from 19 partic...

Boerxio Model (ALFA-OMEGA concept): A testable proposal on globular cluster streams for the Roman Space Telescope

Abstract: Boerxio Model is an exploratory, cyclic, fractal framework (ALFA-OMEGA concept) proposed by an independent researcher as a conceptual interpretation, not as a claim of a final theory. BASE SCHEMA: (1) ALFA - Big Bang as a white-hole bounce beyond Limit X at Planck densi...

COMPARING THE DIFFERENCE IN NURSES' KNOWLEDGE AND ATTITUDES TOWARD NEAR-DEATH EXPERIENCES (NDES) BEFORE AND AFTER RECEIVING NDE EDUCATION

Near-death experiences (NDEs) have been reported in approximately 6.3% to 39.3% of patients who survived death or critical illness. Research indicated that health care professionals, of whom nurses are the largest group, received little education or training on NDEs. Nurses' resp...

Clinical academic careers need structural integration, not individual endurance

Clinical academics are often described as “bilingual” professionals, moving between discovery and care.1 Yet for many, the difficulty is not fluency across two languages, but the absence of a system that allows both to be spoken at once. The experience of working across clinical...

The Three-Dimensional Economics of AI - Rethinking returns when capital, revenue and technological velocity are endogenous

This essay examines whether conventional return analysis remains sufficient when AI capital requirements, revenue or economic value, and technological velocity become increasingly endogenous. It argues that rapid technological advancement can shorten the competitive economic life...

The efficient star-forming regions of stripped-envelope supernovae

Abstract Massive stars ($\ge 8\, \rm {M}_{\odot }$) play a key role in shaping the interstellar medium of galaxies through stellar feedback. However, how these stars form and evolve before exploding as core-collapse supernovae (SNe) remains elusive. We compute for the first time...

Mycorrhizal composition and species dominance mediate forest plant richness and abundance responses to environmental gradients

This dataset contains plot-level data used to examine how mycorrhizal composition and species dominance mediate forest plant richness and abundance responses to environmental gradients across Northeast China. The dataset was compiled from 1,917 forest inventory plots distributed...

Stratified Orbital Waveguide and Resonant Probing: Autonomous Exoatmospheric Anomaly Discrimination and Closed-Loop Dual-Mode Waveform Governance

Stratified Orbital Waveguide and Resonant Probing (SOWP) introduces a closed-loop physical computing framework instantiated across the 100,000-node continuum of the Resonance Processing Unit (RPU) for autonomous space domain awareness (SDA), micro-Doppler kinematic discrimination...

Stratified Waveguide Acoustic Probing (SWAP): Autonomous Sub-Thermocline Waveguide Penetration and Closed-Loop Dual-Mode Acoustic Inversion

Stratified Waveguide Acoustic Probing (SWAP) introduces a closed-loop physical computing framework instantiated across the 100,000-node continuum of the Resonance Processing Unit (RPU) for autonomous sub-thermocline acoustic penetration, shadow-zone illumination, and covert sub-s...

Empirical Validation and Engineering-Hardened Execution of the CNVS Framework

Note: In this new version 3.0 the concept of Invariant Control Graph G_i(t) is introduced, decoupled from the other two Graphs, for the processing of the Global Verification Function.This report presents the empirical engineering validation of the Closed Native Verification Syste...

A Machine-based Decision-maker Toward Benchmarking Interactive Multi-criterion Decision-making Procedures

Interactive multi-criterion decision-making (iMCDM) procedures allow decision-makers (DMs) to provide their preferences to create and compare alternative solutions in an iterative manner and finally arrive at the most preferred Pareto-optimal (PO) solution. Some iMCDM procedures...

Synthesis of functional unknown input observers for MIMO systems with arbitrary relative degree

This paper addresses the design of functional unknown input observers for multi-input multi-output linear time-invariant systems. In contrast to many existing approaches, the proposed method is applicable to systems with arbitrary relative degree, which significantly enlarges the...

Bridging global offshore waves and nearshore coastal conditions with deep learning

This capsule contains the source code and data for SWAN-TC, a physics-guided hybrid framework for high-resolution nearshore wave prediction. It includes the full implementation of the SWAN-T (Transformer surrogate), SWAN-C (residual correction), and the integrated SWAN-TC models....

From AI Maturity to Reopenable Decisions: The AI Native Transition Method v0.2 as an Open, Workflow-Level Decision Artifact

Enterprise AI strategies are commonly organized as maturity assessments, project portfolios, risk frameworks, or technology roadmaps. These approaches are valuable, yet they leave a recurrent managerial problem under-specified: when AI capabilities, costs, platform features, lega...

18F-fluciclovine PET Imaging of Non-PSMA Expressing High-risk Primary Prostate Cancer

A 67-year-old man with rising PSA and palpable prostate lesion underwent prostate MRI, which showed a large PI-RADS 5 lesion confirmed on biopsy as Gleason score 9 (4+5), grade group 5, prostate cancer. 18 F-DCFPyL PET/CT scan for initial stage showed no significant PSMA avidity...