Research works

T cell receptor-engineered T cells for hepatocellular carcinoma: next steps and future perspectives

Abstract Hepatocellular carcinoma (HCC) accounts for a substantial proportion of cancer mortality worldwide, and clinical outcomes remain poor for patients with advanced disease. T cell receptor-engineered T cells (TCR-T) represent an attractive immunotherapeutic modality because...

Common genetic control for grain filling duration and kernel weight in grain sorghum

Abstract Key message The genetic control of GFD in sorghum closely overlaps with that of grain size, is influenced by both pre- and post-anthesis processes, offering new opportunities for yield improvement through targeted breeding and inter-racial trait introgression. Abstract T...

Combined Effects of Sports Bra Support and Running Shoe Cushioning Influence Breast and Running Biomechanics in Female Runners

Background: Sports bras play a critical role in running, with implications for breast discomfort, pain, performance, potential injury risk, and exercise participation for many women. While breast movement has been analyzed across support levels, most studies focus on discrete tim...

Cloud-Based Infrastructure for Artificial Intelligence and Machine Learning Workloads: A Scalable Framework for Saudi Enterprises

In Saudi companies artificial intelligence and machine learning are moving from being mere experiments to becoming operational capabilities, which is leading to an infrastructure issue that goes well beyond the need for computing power. The processes involved in training, fine-tu...

Astrocytic facilitation of somatic NMDARs underpins hippocampal E-S potentiation

EPSP–spike (E-S) potentiation is a form of plasticity defined by a persistent increase in neuronal spike output for a given synaptic input, reflecting enhanced E-S coupling independent of synaptic strength. However, its cellular mechanisms remain poorly understood. Here, we show...

Strong-Field Physics in Intense Few-Cycle Laser Fields: From Carrier-Envelope-Phase Effects to Waveform Engineering

The generation of intense few-cycle laser pulses with a stabilized carrier-envelope phase (CEP) has enabled unprecedented control of strong-field laser–matter interactions on an attosecond time scale. Few-cycle laser fields allow direct manipulation of the instantaneous electric-...

Furnishing Memorial: Gravestones Made from Repurposed Furniture Tops at African American Cemeteries

Abstract More than 100 graves at East End and Evergreen cemeteries, adjacent historical Black burial grounds in Richmond, Virginia, are marked by unusually thin headstones with physical features indicating prior use as the top surfaces of wooden furnishings. Using biographical so...

Der Haus : Evidence of Change in Gender and Number Agreement in One Pennsylvania Dutch Variety

Abstract This article investigates gender and number agreement on definite articles, adjectives, and pronouns in one Pennsylvania Dutch variety spoken by the Amish of Lancaster County, Pennsylvania. The findings, based on eight speakers, suggest that the nominal system in this va...

Explainable spatiotemporal Graph Neural Networks: Multi-City PM2.5 forecasting in Bangladesh with geographic graph topology validation

Accurate forecasting of fine particulate matter (PM 2.5 ) is critical for mitigating severe health risks in South Asia, yet it remains challenging in data-scarce regions like Bangladesh. While spatiotemporal graph neural networks (GNNs) offer a promising solution by capturing atm...

New edge proposed: accumulation_distribution_line_divergence_swing_reversal — E8 Intelligence Research

{ "name": "accumulation_distribution_line_divergence_swing_reversal", "source": "Larry Williams / classic technical analysis (A/D line divergence)", "type": "filter_flag", "rule": "When a 20-bar price swing high makes a higher high vs the prior 20-bar swing high but the Accumulat...

Serum Ang-1, sFLT-1, and sST2 Profiles Distinguish Anti-VEGF Responders in Diabetic Macular Edema

Purpose: Diabetic macular edema (DME) remains a significant cause of vision loss despite the widespread use of anti-VEGF therapy. Nearly half of patients experience suboptimal responses in both anatomical and functional outcomes. This study correlates molecular signatures with cl...

Morphological adaptations of cervical vertebrae in plunge‐diving sulids

Abstract Foraging strategy frequently drives morphological diversification in birds. The plunge‐diving behavior of certain species makes the functional and ecological trade‐offs of variation in cervical vertebrae an especially intriguing question. This study compares cervical ver...

Microbial Degradation of Lignin Generates Iron-Binding Organic Ligands

Abstract The association of organic carbon (OC) with iron (Fe) minerals is a primary mechanism governing soil OC persistence, yet the molecular agents mediating Fe–OC binding remain poorly defined. In this study, we demonstrated that microbial degradation of lignin, one of the ma...

Optimization Method for Measuring and Evaluating Hole-Group Position Under the Combined Effects of Datum Shift and Maximum Material Condition

This paper investigates the combined effects of the Maximum Material Condition (MMC) modifier and datum feature shift on hole-group positional tolerance evaluation. The formulation follows ASME Y14.5-2018 as the primary normative framework, with ISO GPS terminology as a supplemen...

Synthetic Strategies for Oxygenated Cyclohexanoid Frameworks

Highly oxygenated cyclohexanoid frameworks are key structural features in many natural products and remain challenging synthetic targets. Herein, we report investigations into two strategies for their preparation. A high-pressure Diels-Alder reaction enabled the construction of a...

Event-Anchored Early Identification of Mechanical Degradation in ZYJ7 Turnout External Locking Mechanisms Using Phase Energy and Locking Rebound Features

Early mechanical deterioration of ZYJ7 turnout external locking mechanisms is difficult to detect consistently through manual inspection of power curves. This study proposes a mechanism-interpretable method combining event-anchored operating-phase segmentation, relative excess ph...

Interplay among climate, WASH, and socioeconomic factors in child stunting in Bangladesh: a DHS-based analysis

ABSTRACT Child undernutrition remains a public health challenge in Bangladesh. This study examined associations among household water, sanitation, and hygiene (WASH) conditions, climatic factors, socioeconomic characteristics, diarrhoeal disease, and child stunting. Pooled data f...

TaANT11‐4A enhances grain yield by orchestrating photosynthesis and carbohydrate metabolism through direct transcriptional activation

Abstract The AINTEGUMENTA (ANT) transcription factor family plays important roles in floral organogenesis and plant development; however, the mechanisms by which ANT proteins regulate yield remain unclear. Here, we conducted a genome‐wide search and identified 64 ANT genes in the...

A hybrid data-driven and qualitative approach for critical factor identification in pharmaceutical supplier selection: safeguarding the continuity of pharmaceutical in disruption-prone settings

Purpose This study aims to develop a comprehensive and integrated approach for identifying and prioritizing critical factors influencing pharmaceutical supplier selection and supply chain performance, with direct implications for health system resilience and access to essential m...

Testing neurobiological models of reward/incentive sensitization in the continuation of alcohol use disorder (AUD) symptoms in young adults with AUD: A four-year longitudinal study

Abstract Alcohol use disorder (AUD) remains an urgent public health problem. Alcohol response phenotype may be an important factor underlying vulnerability to and progression of AUD. This study examined the prospective association between acute alcohol responses and continued or...