Research works

Comparing Hair Cortisol, DHEA, and Cortisol-to-DHEA Ratios from Various Body Sites in Anatolian Shelter Dogs

Hair-based biomarkers offer a non-invasive window into chronic stress physiology, yet the influence of sampling body site on hair cortisol, dehydroepiandrosterone (DHEA), and their molar ratio has not been systematically characterized in domestic dogs. This study compared these t...

STELT: A spatiotemporal deep learning framework for diffusion-ordered NMR spectroscopy reconstruction with artifact suppression

Diffusion Ordered NMR Spectroscopy (DOSY) is a powerful technique for studying mixtures by probing the diffusion behavior of mixed compounds and enabling their identification and separation in mixture samples. The performance of DOSY generally relies on the adopted reconstruction...

Orthogeriatric Fracture Syndrome: Time Is Mobility!

Bissoto et al [...]

Ketosis as a Treatment for Severe Mental Illness: A Critical Review of Preclinical and Clinical Data

Abstract Purpose Ketogenic interventions, including ketogenic diets, are increasingly being explored as potential treatments for severe mental illnesses. Ketosis – the metabolic state characterised by high circulating levels of ketone bodies – is thought to be central to the bene...

Conformal Assembly of Platinum on Self-Standing Structured Cathodes for PEMFCs

Abstract A self-standing cathode architecture for proton exchange membrane fuel cells was developed. A conformal, thin layer of platinum was electrodeposited on a self-standing carbon-fiber-based structured support in the form of an extended-surface particulate film. Abundant gra...

Exosomal hnRNPA1‐delivered miR‐27a‐3p inhibits the radiation‐induced bystander effect in cervical cancer

Abstract Purpose The radiation‐induced bystander effect (RIBE) refers to biological responses in non‐irradiated cells exposed to signals from irradiated cells and may contribute to tumor control during radiotherapy. Periodic dose heterogeneity caused by the thread effect of helic...

Persistent Terrestrial Technology Core for Progressive Lunar Industrial Closure

English description Persistent Terrestrial Technology Core for Progressive Lunar Industrial Closure This preprint presents an analytical framework for studying the progressive industrial closure of a lunar production system through the development of a persistent terrestrial tech...

Deep learning-powered virtual eosin-based elastic fiber framework imaging improves objective grading and prognostic stratification of lung adenocarcinoma

Histological grading of lung adenocarcinoma is limited by interobserver variability, particularly when distinguishing noninvasive lepidic growth from invasive patterns. This distinction depends on evaluation of the alveolar elastic fiber framework, which is often insufficiently v...

Association Between Interlimb Asymmetry in Normalized Vastus Medialis sEMG Amplitude and Functional Mobility in Patients with Post-Traumatic Knee Contracture: A Cross-Sectional Study

Background/Objectives: Patients with post-traumatic knee contracture often present with limited range of motion (ROM) and impaired functional mobility, but functional performance may not be fully explained by ROM and pain alone. This study aimed to examine whether normalized vast...

Aero-DETR: a frequency-adaptive sparse-interaction network for UAV-assisted aircraft surface defect detection

Abstract Aircraft surface defect inspection is critical for aviation safety but remains challenging because defects in unmanned aerial vehicle (UAV) imagery are often small, low-contrast, and multi-scale. We construct the aircraft UAV defect inspection dataset (AUDID), containing...

An explainable biomedical foundation model via large-scale concept-enhanced vision–language pretraining

Artificial intelligence for medical imaging is required to be accurate and interpretable to clinicians. However, current multimodal biomedical foundation models often prioritize performance over explainability. Here we present ConceptCLIP, an explainable biomedical foundation mod...

Control-as-Load Condition v0.2: A State-Dependent Hypothesis on Additional Control Activity and Subsequent Recoverability

This technical note presents Control-as-Load Condition v0.2 as a standalone and empirically testable hypothesis. The central proposal is that the recovery-related effect of additional Control activity varies with within-person state, while task performance is treated as a separat...

Multi-objective optimisation of renewable energy integration in circular brine valorisation/treatment: The case of the CARMEn chain

Circular brine-valorisation chains offer a promising route to address water scarcity and critical raw-material recovery, but their large electrical and thermal energy demands can offset environmental benefits if powered by fossil sources. This work develops a fully integrated, ho...

State-of-Art on Multidisciplinary Approaches to Meningioma: A Systematic Review of the Available Evidence

Background: Meningiomas are the most common primary intracranial tumors, often requiring complex management due to their proximity to critical neurovascular and orbital structures. While surgery remains the cornerstone of treatment, achieving optimal outcomes requires coordinated...

Manuscripts & Books: Search Guide (Phase 1: Tools & Basic Guidelines)

This presentation outlines the fundamental digital tools and software prerequisites required for advanced academic research, with a specific focus on locating historical manuscripts and digital books. As the foundational phase of a comprehensive research training workshop, this g...

Body Composition–Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation

Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (...

The UOHF Human Function Capacity System, Version 1.0: Unified Definitions of 18 Core and 104 Specific Human Functional Capacities

The Unified Ontology of Human Function (UOHF) defines human function as the body's capacity to be appropriately engaged to meet internal and external demands. Building on the prior UOHF conceptual and formal frameworks, this preprint publishes Version 1.0 of the UOHF Human Functi...

Multiparameter urine reagent strips for bedside identification of cerebrospinal fluid in epidural catheter aspirates: a proof-of-concept observation

Aspiration of clear fluid from an epidural catheter is a recurring, high-stakes clinical challenge. It may be residual saline from loss of resistance, local anesthetic (LA), or cerebrospinal fluid (CSF)—all visually indistinguishable. This matters because a full epidural LA dose...

BFMambaNet: Boundary-Frequency-Guided Global Semantic Mamba Network for Fine-Grained Camellia oleifera Leaf Disease Segmentation

Camellia oleifera leaf disease segmentation under natural field conditions is important for precision plant protection but remains challenging because lesions often show small target areas, blurred boundaries, uneven illumination, complex backgrounds, and coexisting symptoms. To...

HMGB1 andHMGB2 Are O 4-Alkylthymidine-BindingProteins

Abstract Exposure to endogenous and exogenous sources of alkylating agents leads to DNA lesions that can impair cell survival and confer genome instability by eliciting mutations during DNA replication and transcription. Among the DNA alkylation adducts, O4-alkylthymidine (O4-alk...