Research works

NOSE-TO-BRAIN DRUG DELIVERY THROUGH NASYA KARMA IN PARKINSON'S DISEASE: AN AYURVEDIC–NEUROSCIENTIFIC CORRELATION

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by tremors, rigidity, bradykinesia, and postural instability, along with several non-motor symptoms that adversely affect quality of life. Although conventional treatments provide symptomatic relie...

A REVIEW OF VACHADI GANA KALA BASTI AND HARIDRADI GANA KALA BASTI IN THE MANAGEMENT OF DYSLIPIDEMIA (SHONITA ABHISHYANDA)

Dyslipidemia, marked by deranged levels of Total Cholesterol, Triglycerides, LDL, VLDL and HDL, is a rapidly growing metabolic disorder associated with sedentary lifestyle, faulty dietary habits, obesity and insulin resistance, and is an important risk factor for cardiovascular d...

SOLUBILITY AND BIOAVAILABILITY ENHANCEMENT OF POORLY WATER-SOLUBLE DRUG GLIMEPRIDE

The present study owed to enhance the dissolution and potential bioavailability of poorly water-soluble glimepiride (GP) through the formulation of solid dispersions using suitable hydrophilic carriers. Solid dispersions and physical mixtures of glimepiride were prepared employin...

ADAPT-EPILEPSY: AN AI-AUGMENTED SPATIOTEMPORAL PREDICTIVE MODELING PROTOCOL FOR OPTIMIZING REPEAT MRI TIMING IN PEDIATRIC SEIZURES

Currently, repeat MRI in pediatric epilepsy is reactive and empiric (mean 537 days) leading to delayed diagnosis of structural lesions, unnecessary sedation and suboptimal surgical referral rates. We developed the ADAPT-Epilepsy protocol, a spatiotemporal predictive model augment...

ENDOCAN، ASOLUBLE MARKER OF ENDOTHELIAL CELL ACTIVATION, AS AMARKER OF DISEASE SEVERITY IN WOMEN WITH PREECLAMPSIA

Background: Preeclampsia is a pregnancy-specific multisystem disorder characterized by new-onset hypertension after 20 weeks of gestation accompanied by proteinuria and/or maternal organ dysfunction, and endothelial dysfunction is considered its central pathological mechanism. En...

MANAGEMENT OF STRESS-INDUCED INSOMNIA (ANIDRA) WITH BALA ASHWAGANDHADI TAILA SHIRODHARA AND CLASSICAL AYURVEDIC MEDICATIONS: A CASE REPORT

Insomnia (Anidra) is a common sleep disorder associated with psychological stress, prolonged screen exposure, and an irregular lifestyle. Ayurveda attributes Anidra primarily to the aggravation of Vata and Pitta Dosha with involvement of Manovaha Srotas, and recommends Panchakarm...

TRANSFEROSOMES IN TRANSDERMAL DRUG DELIVERY SYSTEM: STRUCTURE, MECHANISM AND THERAPEUTICS

Transdermal drug delivery systems (TDDS) have gained significant attention as a non-invasive alternative to conventional oral and parenteral drug administration, as they bypass first-pass metabolism, reduce gastrointestinal degradation and improve patient compliance. Despite thes...

A COMPREHENSIVE REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM

Gastro-retentive drug delivery systems (GRDDS) are advanced oral delivery approaches designed to prolong gastric residence time and improve the therapeutic performance of drugs with site-specific absorption or gastric activity. Conventional dosage forms may undergo rapid gastric...

DEVELOPMENT AND EVALUATION OF A SAMYAKA VAMANA ASSESSMENT SCORE (SVAS): A NOVEL TOOL FOR OBJECTIVE EVALUATION OF VAMANA KARMA

Background: Vamana Karma is a principal bio-purificatory procedure in Ayurveda. Traditionally, its adequacy is assessed using four classical parameters: Vaigiki, Maniki, Antiki, and Laingiki Shuddhi. However, objective assessment remains challenging due to the lack of a standardi...

The Aesthetics of Fear

This article begins with an initial reflection on a personal question taken as the point of departure for research: why human beings are persistently confronted with states such as unease, anxiety, and a continuous condition of concern and preoccupation. Distancing itself from bi...

ROLE OF HERBAL MEDICINES IN THE MANAGEMENT OF POLYCYSTIC OVARY SYNDROME (PCOS): A REVIEW

Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder commonly affecting women of reproductive age. In India, nearly two out of every ten women are affected by PCOS. The condition is characterized by polycystic ovarian morphology, ovulatory dysfunction, and hyperandr...

AYURVEDIC MANAGEMENT OF AGNIVISARPA (PITTA-RAKTA PRADHANA VISARPA) IN AN ELDERLY FEMALE: A CASE REPORT

Background: Agnivisarpa is a Pitta-Rakta predominant variety of Visarpa characterized by erythema, burning sensation, inflammation, and rapid progression. In Ayurvedic classics, Visarpa is described as a rapidly spreading inflammatory disorder involving vitiation of Dosha, Rakta,...

A CASE STUDY ON ROPANIYA KARMA OF KAMPILLAKA TAILA ON NON HEALING ULCER

A non healing ulcer is a sore or wound on the skin or mucous membrane that fails to heal within normal time frame despite treatment. They may be due to poor blood supply, diabetes, infection, chronic pressure, venous insufficiency, poor nutrition.[1] According to Ayurveda Non Hea...

FORMULATION AND EVALUATION OF PREBIOTIC BIOGEL FROM GARCINIA INDICA(RIND) FOR SKIN HEALTH

The present study focused on the formulation and evaluation of a prebiotic biogel containing Garcinia indica (kokum) rind extract for potential skin-care applications. Kokum rind was shade-dried, powdered, and extracted using 70% ethanol by maceration. The obtained extract was su...

FROM CORRESPONDENCE TO SCIENTIFIC VALIDATION: AN EVIDENCE-GRADED CRITICAL REAPPRAISAL OF THE AYURVEDIC AGNI–AMA FRAMEWORK IN THE CONTEXT OF GUT MICROBIOME SCIENCE

Background: Ayurveda, the ancient Indian system of medicine, conceptualizes digestive health through two cardinal constructs: Agni (the biological transformative fire) and Ama (the pathological residue of impaired digestion). Contemporary gut microbiome science has identified fun...

FORMULATION AND EVALUATION OF A POLYHERBAL EMULSION CONTAINING LINUM USITATISSIMUM, ALOE BARBADENSIS & ROSMARINUS OFFICINALIS FOR TOPICAL APPLICATION

The present study was aimed at developing and evaluating a polyherbal emulsion containing Linum usitatissimum (flaxseed), Aloe barbadensis (Aloe vera), and Rosmarinus officinalis (rosemary) for topical application. These herbal ingredients were selected because of their reported...

MANAGEMENT OF STHOULYA ASSOCIATED WITH JANU SANDHIGATA VATA: A CASE REPORT

Background: Sthoulya (obesity), a Santarpanajanya Vyadhi described in Ayurveda, is characterized by excessive accumulation of Meda Dhatu and Kapha Dosha, leading to impaired physical function and increased susceptibility to various metabolic and musculoskeletal disorders. Obesity...

A COMPREHENSIVE REVIEW OF MEDHYA RASAYANAIN AYURVEDIC PEDIATRIC PRACTICE

Ayurveda is founded on two fundamental principles: the preservation of health in healthy individuals and the management of diseases in those who are ill. Among the eight classical branches of Ayurveda, Rasayana is primarily concerned with rejuvenation, healthy aging, and the prom...

LIFESTYLE MODIFICATION AND HERBAL MEDICINES IN THE MANAGEMENT OF POLYCYSTIC OVARY SYNDROME (PCOS)

Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder affecting women of reproductive age, characterised by hormonal imbalance, ovulatory dysfunction, menstrual disturbances, hyperandrogenism, and metabolic abnormalities. Lifestyle modification plays a cen...

ANUVĀSANA BASTI IN THE PREPARATION FOR SUKHAPRASAVA: A CRITICAL REVIEW

The third trimester is a crucial period of fetal growth, cervical maturation, increasing pelvic pressure and preparation for labour. Ayurveda describes Garbhini Paricharya for maintaining maternal and fetal health and promoting Sukhaprasava. In the ninth month, Acharya Charaka re...