Research works

ANALYTICAL METHOD VALIDATION AND IMPURITY PROFILING OF TIRZEPATIDE: A CRITICAL REVIEW FROM A REGULATORY QUALITY ASSURANCE PERSPECTIVE

Background: Tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, represents a significant advancement in the management of type 2 diabetes and obesity. However, its complex peptide structure necessitates robu...

A COMPREHENSIVE REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM

Gastro-retentive drug delivery systems (GRDDS) are advanced oral delivery approaches designed to prolong gastric residence time and improve the therapeutic performance of drugs with site-specific absorption or gastric activity. Conventional dosage forms may undergo rapid gastric...

EFFECTS OF ALCOHOLIC EXTRACT OF POMEGRANATE PEEL (PUNICA GRANATUM) ON GHRELIN AND RESISTIN HORMONE LEVELS, LIPID PROFILE AND BODY WEIGHT IN EXPERIMENTAL MICE

This study included extraction of phenolic compounds from pomegranate peels using a continuous extraction apparatus (Soxhlet) with 70 % Ethanol. Qualitative Screening of the Pomegranate Peel Ethanolic extract revealed a high content of Polyphenols, Tannins, Flavonoids, and Anthoc...

PHYSICOCHEMICAL STANDARDIZATION, PHYTOCHEMICAL PROFILING, AND BROAD-SPECTRUM ANTIBACTERIAL ACTIVITY OF CASSIA ANGUSTIFOLIA

Cassia angustifolia (Fabaceae), commonly known as Senna is a medicinal plant extensively used in traditional systems of medicine for gastrointestinal and inflammatory disorders. The present study investigated the physicochemical characteristics, qualitative phytochemical composit...

CLOSED-LOOP AND ON-DEMAND CONTRACEPTIVE TECHNOLOGIES: A REVIEW OF SMART DEVICES FOR FERTILITY CONTROL IN MEN AND WOMEN

Contraceptive technology is shifting from passive, user-dependent methods toward active, responsive systems built on advances in materials science, microelectronics, and formulation engineering. This review summarizes emerging smart contraceptive technologies for men and women, o...

AYURVEDIC MANAGEMENT OF MUTRASHMARI W.S.R TO UROLITHIASIS: A CASE STUDY

Mutrashmari (urinary stones) is one among the Ashtamahagada (eight fatal conditions) and is Kapha pradhan Tridoshaja Vyadhi, which is correlated with urolithiasis. It is the major cause of morbidity. The prevalence rate of urolithiasis is approximately 12% in world. Many treatmen...

DESIGN, SYNTHESIS, AND ANTIMICROBIAL EVALUATION OF NOVEL ISATIN–MOXIFLOXACIN-BASED 1,2,3-TRIAZOLE DERIVATIVES

The increasing emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis has created an urgent need for the development of new antimycobacterial agents with improved efficacy. In the present study, a series of six novel isatin–moxiflox...

A STUDY TO ASSESS THE EFFECTIVENESS OF CPR TRAINING PROGRAM ON KNOWLEDGE AND PRACTICE SKILL REGARDING CARDIOPULMONARY RESUSCITATION AMONG BSC NURSING STUDENTS OF SELECTED NURSING COLLEGES, KOLLAM."

A quantitative study was conducted to assess the effectiveness of a CPR training program on knowledge and practice skill regarding cardiopulmonary resuscitation among B.Sc. Nursing students of selected nursing colleges, Kollam. A quasi-experimental one-group pretest-posttest rese...

AN INTEGRATIVE APPROACH TO FOOT HEALTH: AYURVEDIC PRINCIPLES AND CONTEMPORARY MANAGEMENT

Foot-related problems such as Padadari (Padasphutana), Vipadika, excessive sweating, unpleasant foot odour, itching, skin infections, nail disorders, burning sensation of the soles, and chronic wounds can cause considerable discomfort and may interfere with walking and daily acti...

HIDDEN POLLUTION IN IRRIGATION SYSTEMS: MICROPLASTICS IN SURFACE AND GROUNDWATER OF THE PAZHAYAR RIVER BASIN, SOUTH INDIA

Microplastic (MP) contamination from anthropogenic sources has been repeatedly proposed as an environmental threat based on its possible ecological and human health impacts, due to its persistent nature. The research aimed to explore the occurrence, distribution, characteristics...

SHATKRIYAKALA: AN AYURVEDIC FRAMEWORK FOR EARLY DIAGNOSIS AND THERAPEUTIC INTERVENTION IN DISEASE PROGRESSION

Shatkriyakala is an important Ayurvedic concept that describes the sequential stages of disease development and identifies the appropriate time for therapeutic intervention. It is closely associated with the process of disease pathogenesis and emphasizes early diagnosis and timel...

The Patterned Universe: Linking Science, Art, and the Structures of Reality

This study proposes that patterns constitute a generative basis of reality, cognition, and meaning, offering a conceptual framework linking the physical sciences, biological systems, cognitive processes, and artistic practice. Patterns appear widely, from atomic lattices and flui...

WISDOM OF AYURVEDA FOR MODERN WELLNESS: RTU SHODANA FOR TODAY'S HEALTH NEEDS

Rtu Shodana, the seasonal bio purification therapy described in Ayurveda, serves as a vital tool in maintaining health and preventing disease by aligning the body with nature’s cyclical changes. Rtu Shodana involves tailored bio purification procedures such as Vamana, Virechana,...

ACUTE ORAL TOXICITY OF MRITYUNJAYA RASA IN WISTAR ALBINO RATS ACCORDING TO OECD GUIDELINE 423

Background: Mrityunjaya Rasa is a classical Ayurvedic herbo-mineral formulation widely prescribed for the management of fever, gastrointestinal disorders, and various Vata-Kapha predominant diseases. As it contains processed mineral ingredients, scientific evaluation of its safet...

EVALUATION OF SOME HEMOSTATIC ABNORMALITIES IN CHRONIC KIDNEY DISEASE PATIENTS PRE AND POST HEMODIALYSIS

Background: Chronic kidney disease and hemodialysis associated with disturbance in hemostasis. Uremic toxins induced platelet dysfunction, coagulopathy, endothelial dysfunction and impaired fibrinolysis. Aim: To evaluate some hemostatic abnormalities in patients with chronic kidn...

ENDOCAN، ASOLUBLE MARKER OF ENDOTHELIAL CELL ACTIVATION, AS AMARKER OF DISEASE SEVERITY IN WOMEN WITH PREECLAMPSIA

Background: Preeclampsia is a pregnancy-specific multisystem disorder characterized by new-onset hypertension after 20 weeks of gestation accompanied by proteinuria and/or maternal organ dysfunction, and endothelial dysfunction is considered its central pathological mechanism. En...

A REVIEW ON AND PHARMACOGNOSTIC PHARMACOLOGICAL ACTIVITIES OF CURCUMA LONGA L.

Turmeric (Curcuma longa L.) is a popular natural drug, traditionally used for the treatment of a wide range of diseases. Its root, as its most popular part used for medicinal purposes, contains different types of phytochemicals and minerals. This review summarizes what is current...

FUNCTIONAL CHANGES IN HUMAN BRAIN IN ANXIETY DISORDERS: A REVIEW

Anxiety disorders rank among the most prevalent psychiatric disorders worldwide. Ayurveda approaches mental disorders through functional concepts such as being imbalanced Dosha or malfunctioning of the Manovaha Srotas. The aggravation of Vata demonstrates considerable similarity...

ANTIMICROBIAL SUSCEPTIBILITY AND BIOFILM FORMATION PROFILES OF Escherichia coli ISOLATES IN STORED DRINKING WATER FROM THREE COMMUNITIES IN EGOR LOCAL GOVERNMENT AREA, EDO STATE, NIGERIA

Access to clean and safe drinking water remains a significant challenge in many rural areas, with improper storage and contamination posing serious risks to public health. This study examines various factors influencing the quality of stored drinking water, including sociodemogra...

URTICA (NETTLE) SPECIES OF ISRAEL AND PALESTINE – A MINIREVIEW

Urtica (Nettle) species are well known in the “Old World” for their painful stings. This property attracted human attention since antiquity and humans used these plants for various medicinal purposes, and for limited nutrition. Modern research approved the ethnomedicinal uses and...