Research works

Sequence-free landscape inference for directed evolution

Abstract Directed evolution is a method for engineering biological systems or components, such as proteins, wherein desired traits are optimised through iterative rounds of mutagenesis and selection of fit variants. The process of protein directed evolution can be envisaged as na...

NucGen3D: A synthetic framework for large-scale 3D nuclear segmentation with open-source training data and models

A bstract Robust nuclear segmentation in 3D microscopy images is a critical yet unresolved challenge in quantitative cell biology, hindered by the scarcity and variability of annotated volumetric datasets. Because such data are difficult to obtain, most state-of-the-art approache...

Semiclassical tunneling for some 1D Schrödinger operators with complex-valued potentials

We consider the non-selfadjoint, semiclassical Schrödinger operator \mathscr{L}(h) := -h^{2}\partial_{x}^{2}+e^{i\alpha}V , where \alpha \in (-\pi,\pi) and V\colon \R\to \R_{+} is even and vanishes at exactly two (symmetric) non-degenerate minima. We establish a semiclassical tun...

String problems in the congested clique model

In this paper we present algorithms for several string problems in the Congested Clique model. In the Congested Clique model, n nodes (computers) are used to solve some problem. The input to the problem is distributed among the nodes, and the communication between the nodes is co...

Classical BV cohomology of the N = 1 spinning particle

A bstract We show that the classical Batalin-Vilkovisky cohomology at negative ghost number of the spinning particle, observed in ref. [1], is removed by a Koszul-Tate resolution involving saturation of Grassmann odd variables. The model thus satisfies the axioms of Felder and Ka...

Varied average height and area coverage of rough surfaces on turbulent boundary layers

Abstract Turbulent boundary layer (TBL) over various area coverages of rough surfaces was studied in a wind tunnel using hot-wire anemometry. The rough surfaces are built by randomly distributed sand grains with an average of 0.7 and 0.9 mm heights, covering 12%, 25%, 38%, 55%, a...

Equity Frictions and Firm Ownership

Abstract In this paper, I document systematic heterogeneity in ownership and financing of firms across Eurozone countries. To rationalize these differences, I build a quantitative general equilibrium model of workers and entrepreneurs who choose debt and equity financing of their...

A Novel Relationship Between Gamma Ray Burst Duration and Photospheric Radius

Abstract Long gamma-ray bursts (lGRBs) are associated with jets in Type Ic broad-line supernovae. The collapsar model provides a theoretical framework for the jet formation from the core collapse of a massive star in such supernovae. The gamma-ray burst (GRB) can only be produced...

Evidence for Turbulent Concentration in Particle-laden Midplane Layers of Planet-forming Disks

Abstract We investigate the axisymmetric, weakly turbulent state of settled particle layers in a model of a globally laminar protoplanetary disk. We focus on conditions in which the large-scale axisymmetric filaments associated with the streaming instability (SI) either cannot fo...

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their...

The metacognitive paradox of OCD: confidence is globally reduced but shows increased sensitivity to local evidence

Confidence is a critical metacognitive signal that guides performance. Biases in confidence, such as excessive doubt, are hallmark features of mental health disorders, especially obsessive-compulsive disorder (OCD). Yet, the underlying neurocognitive mechanisms and how they link...

Ionospheric response characterization during geomagnetic disturbances: EISCAT Svalbard Radar analysis (2007)

This work analyses polar cap ionospheric variability and predictive modelling using EISCAT Svalbard Radar (ESR) data from March 2007 to February 2008 during solar minimum. Over four million ESR measurements were combined with ionosonde observations and space weather indices to ch...

Open public data and stock price delay: evidence from a quasi-natural experiment in China

Stock price delay serves as a key metric of information efficiency in stock markets, and identifying its determinants is essential for promoting market information efficiency. This study examines the effect of open public data (OPD) on stock price delay. Using the staggered adopt...

Smart power limits: Designing shortage mechanisms for extreme events

As shortages of resources like water and electricity due to extreme weather events become more frequent, high prices alone may fail to curb demand, making shortages more common. We examine a power limit policy for residential electricity households that rations electricity consum...

Growth factor-based manufacturing of human pluripotent stem cell-derived cardiomyocytes using the vertical wheel bioreactor system

Abstract Background Multiple protocols have been reported for the large-scale generation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) in bioreactors using small molecules; however, no comparable bioreactor-based methods have been established using growth facto...

Refining the Simulation of Mixed‐Phase Clouds Over Coastal Antarctica With a Tailored Ice Nucleating Particle Parameterization

Abstract Climate models have substantial biases in downwelling shortwave radiation over the Southern Ocean (SO) and Antarctica, primarily due to their inability to accurately represent the frequent occurrence of low‐level mixed‐phase clouds. Building on the evaluation of the Unif...

Developing a coastal hazard prediction system in ice-infested waters – Part 1: High-resolution regional wave modeling in the Estuary and Gulf of St. Lawrence

Abstract. This study is the first of a two-part paper that summarizes the development of a prototype coastal hazard prediction system providing short-term (+48 h) forecasts of the total water level (TWL) at 50 m resolution for the province of Quebec, Eastern Canada. In this first...

Activation of IL-17+ ILC subsets in IL-18R-deficient mice during fungal allergen exposure

Abstract Group 2 innate lymphoid cells (ILC2s) are critical players during type 2 inflammation present in most forms of asthma. ILC2s are tissue-resident cells that produce cytokines IL-5 and IL-13 critical to eosinophilic airway inflammation, mucus production, remodeling, and hy...

Quantifying Heartbeat Micro-Fragmentations Post-Myocardial Infarction Using Wavelet Entropy and Complexity

Cardiovascular diseases are recognized as one of the leading causes of mortality, with myocardial infarction (MI) being a critical condition that disrupts the heart’s electrical conduction due to myocardial tissue damage. The aim of this study is to examine two key phases followi...

A suction-controlled laboratory campaign for assessing the hydro-mechanical properties of a compacted silty sand mixture

Due to continuous water level fluctuations and changes in climatic boundary conditions, river embankments experience frequent variations in the degree of saturation and suction distributions, which strongly influence earthworks performance, both in terms of infiltration regime an...