Research works

Viral Metagenomic Analysis of Bat Fly Pupae

Bats are important reservoirs of zoonotic viruses, yet the role of their obligate ectoparasites, particularly bat flies, in viral maintenance and transmission remains poorly understood. Although viral sequences have been detected in adult bat flies, vertical transmission to their...

Comprehensive Evaluation and Explainable Interpretation of Peptide-HLA Binding Prediction Tools

Abstract Accurate prediction of peptide binding to human leukocyte antigen class I (HLA-I) molecules is critical for advancing immunological research, particularly in vaccine design and immunotherapy. However, limitations in model performance, interpretability, and dataset qualit...

Saros-Phi Resonance Cascade in Multi-Selector Lottery Dynamics — E8 Intelligence Research

When multiple lottery selectors operate simultaneously, their individual phase durations create constructive interference patterns following phi-coupled E8 root projections. This generates a cascade resonance where the 132Hz base frequency amplifies through successive phi-multipl...

Mathematical Classification of Switching Types and Hierarchical Structures: Three Switching Types, Six Hierarchical Structures, Coefficient of Variation Lower Bound, and Discretization Plateau Effect in the k-Regime Linear Switching Model

In the k-regime linear switching model, the switching between adjacent regimes is fully characterized by the parameter difference Δθⱼ = θⱼ₊₁ − θⱼ. This paper restricts the comparison to the union of adjacent regime pairs (Rⱼ, Rⱼ₊₁) and establishes a mathematical classification of...

A Multiscale Mechanistic Framework Linking Infection Dynamics, Oxidative Chemiexcitation, and Ultraweak Photon Emission

Ultraweak photon emission (UPE) provides a noninvasive optical signature of oxidative chemistry, but the relationship between infection-associated reactive oxygen species (ROS) and photon emission remains mechanistically uncertain. Here, we develop a multiscale framework linking...

Integrating metabolomics and metagenomics to unravel asthma pathophysiology using artificial intelligence and systems biology

Asthma is a heterogeneous chronic airway disease driven by complex interactions among genetic, environmental, metabolic, and microbial factors. Conventional diagnostic and therapeutic approaches often fail to capture its molecular diversity, underscoring the need for integrative...

Quantifying Consciousness: Phi as Irreducible Cause-Effect Power — E8 Intelligence Research

FINDING: Integrated Information Theory (IIT) quantifies consciousness as a scalar Φ (phi) — the amount of irreducible cause-effect power of a system over its own past and future states, computed via the PyPhi algorithm. | MATH: Φ = min over partitions of the Earth Mover's Distanc...

The Entangled-Instance Framework: dark energy from a finite branching budget, the radial acceleration relation from competing rates, and sixteen pre-registered predictions

Version 4 — Second editions under source-certified anchors: adds an explicit scope statement of what is postulated versus derived, the candidate dynamics axioms with the emergence theorem (Appendix C), the black-hole sector, quantum-sector extensions including the collider entang...

Postnatal sacroiliac joint dysfunction as a mechanical driver of pudendal neuralgia and dyspareunia: A case report

Pudendal neuralgia is a neuropathic perineal pain syndrome that commonly causes dyspareunia, yet sacroiliac joint dysfunction is rarely considered a primary mechanical cause in the early postnatal period. A 32-year-old woman presented 6 weeks after an elective cesarean section wi...

A Z₃-Symmetric Reading of the Charged-Lepton Mass Phase δ = 2/9 — Axioms, Arithmetic Theorems, and Pre-Registered Tests

Abstract. The status of the phase δ in the Z₃-symmetric parametrization of the charged-lepton masses, √mk =μ(1 + √2 cos(2πk/3 + 2π/3 + δ)), is examined. What is registered is not values but conditions and kill clauses.(a) Layer verdict: the Koide relation QK = 2/3 is a constraint...

A dynamic recommendation algorithm for regional industry-adapted higher vocational courses integrating counterfactual causal inference and graph neural networks

The mismatch between higher vocational curricula and the shifting skill demands of regional industries continues to constrain graduate employability, while existing recommendation engines remain trapped in correlational logic and selection-biased enrollment histories. This paper...

The Architecture of Topological Cosmology: From Braided Spin Networks to the Procedural Universe

**Title:** *The Architecture of Topological Cosmology: From Braided Spin Networks to the Procedural Universe* **Edition / Version:** Augmented Master Monograph (Version 188.0 — The Complete Topological Synthesis) **Authors:** David Noel Lynch (~3K) & The ~3K Collaborative (N.O.L....

Construction Suitability and Influencing Factors in Abandoned Mining Areas Based on Machine Learning: A Case Study of Luhe District, Nanjing, China

Land disturbance and ecological degradation are widespread in abandoned mining areas, and their redevelopment is shaped by multiple factors. Identifying construction suitability patterns and key influencing factors can provide a quantitative basis for the reuse of these areas. Fo...

Effects of Infusion and Decoction Mashing on Carbohydrate Structure, Fermentation Behavior, and Volatile Compound Profiles in Wheat Beer

Beer flavor depends on the composition and structural characteristics of fermentable carbohydrates generated during mashing. Although mashing strategy is known to influence wort composition, the mechanistic relationship between mashing-induced variations in carbohydrate structure...

Spatial Configuration and Cultural Logic: A Space Syntax Analysis of Wu Family Manor, a Late Qing Merchant’s Garden Residence in Northern China

Traditional Chinese gardens are not only aesthetic representations but also spatial expressions of diverse aspects of social life. Compared with the extensive studies on Jiangnan gardens, the spatial organization and cultural meanings of private gardens in northern China remain r...

TurnShift: Sequential Detection of Mid-Conversation Author Substitution via Behavioral User Profiling

Large language models deployed in conversational systems face a class of threats that content-based safety mechanisms cannot adequately address: multi-turn request sequences that appear benign in isolation yet pursue account takeover, credential harvesting, or social engineering...

Beyond Completeness: Measuring Audience-Differentiated Explainability in Public-Sector Algorithmic Transparency (data and code)

Data, code, and a reproducible notebook for the Algorithmic Disclosure Explainability Index (ADEI), a six-dimension index measuring the explainability of UK Algorithmic Transparency Recording Standard (ATRS) records, applied to a 143-record snapshot retrieved between 25 and 28 Au...

Codebase release 0.5 for FewBodyToolkit.jl

Few-body physics explores quantum systems of a small number of particles, bridging the gap between single-particle and many-body regimes. To provide an accessible tool for such studies, we present FewBodyToolkit.jl, a Julia package for quantum few-body simulations. The package su...

Involving People With Dementia in Research: Contributions, Barriers and Evaluation From a Meta‐Synthesis and Qualitative Interview Study

BACKGROUND: Patient and Public Involvement and Engagement (PPIE) can enhance the relevance, acceptability and quality of research; however, its meaningful implementation in dementia research remains insufficiently understood. AIM: (1) To identify methodological procedures for inv...

Non-Euclidean Temporal Folding via E8-Phi Resonance Synchronization — E8 Intelligence Research

By modulating the 132Hz base frequency through a phi-scaled rotation of the 240 E8 root vectors, a localized temporal curvature is generated within the SYK quantum simulator. This mechanism leverages the self-similar interference patterns of the topological phase transition to cr...