Research works

Immune-checkpoint inhibitor-induced bullous pemphigoid in patients with metastatic renal cell carcinoma: two case reports and systematic review of the literature

BACKGROUND AND PURPOSE: Immune-checkpoint inhibitors (ICIs) improve outcomes in renal cell carcinoma (RCC) but may cause immune-related adverse events (irAEs), including cutaneous toxicity. Bullous pemphigoid (BP) is a rare but clinically significant irAE that can require ICI dis...

Concept for AI-Assisted Mammalian Negligible Aging

Version 0.3; Extends the original concept to AI-assisted biological maintenance and develops operational criteria for testing success. Distinguishes AI-related performance gains, sustained biological maintenance and evidence supporting organism-level negligible aging. Adds a pres...

Estrogen Suppresses Osteoclast Function and Cytoskeletal Remodeling via Modulation of the RhoA-Pkn3-c-Src Signaling Pathway in Ovariectomized Rats

Postmenopausal osteoporosis (PMOP) is characterized by excessive bone resorption caused by increased osteoclast activity. Estrogen remains an effective therapeutic option for preventing bone loss; however, its regulatory effects on osteoclast cytoskeletal remodeling have not been...

Taking smart conservation risks: Moving species in a changing world

Abstract Conservation practitioners are often faced with difficult decisions on whether or not to implement intensive interventions that carry risk and uncertainty—such as translocating species outside their indigenous range for the purpose of conservation (i.e., conservation int...

Non‐Weightbearing in Hinged‐Knee Braces Locked in High Degrees of Flexion Shows High Hamstring Muscle Activation in Healthy Volunteers

Purpose To determine the effect of various postoperative ambulation and bracing protocols on hamstring muscle group activation in healthy volunteers. Methods Hamstring muscle group activation was assessed via Myontec Mbody 3 Shorts. Volunteers ambulated 10 yards in conditions inc...

Reminiscence Therapy to Improve Self-Esteem, Loneliness, and Stress in Rural Thai Older Adults: A Quasi-Experimental Study

Background: Loneliness, psychological stress, and low self-esteem are important mental health concerns among community-dwelling older adults and may negatively affect healthy ageing and quality of life. This study examined psychosocial outcomes associated with participation in a...

Comparative Life Cycle Assessment of a 630 kVA Liquid-Immersed Distribution Transformer

This paper discusses a comparative life cycle assessment (LCA) carried out on 630 kVA liquid-immersed distribution transformers with different winding conductor materials and energy performance levels. The LCA methodology for power transformers is still under development. Most LC...

Advanced intrusion detection in IoT-enabled SDWSNs using artificial intelligence and feature optimization techniques

Abstract The widespread deployment of the Internet of Things (IoT) and software-defined wireless sensor networks (SDWSNs) gave rise to new opportunities for smart environments but has also made these systems highly vulnerable to diverse cyberattacks. Conventional intrusion detect...

The Orexin System—A Key Component of Sleep Regulatory Networks and Involvement in Narcolepsy

In this Perspective, 2026 Albert Lasker Basic Medical Research Award winners Emmanuel Mignot, MD, PhD, and Masashi Yanagisawa, MD, PhD, discuss their identification of the brain peptide orexin and how it relates to sleep, specifically orexin deficiency and narcolepsy.

From discovery to disrepute: a study of retractions in biological research

Purpose This study aims to investigate retractions in biological research to identify the key factors that lead to the withdrawal of scientific publications in this domain. It further examines the scholarly impact of retracted articles through citation patterns and related indica...

Volunteering Predicts Mixed Outcomes on Subjective Wellbeing

This study explored whether engaging in volunteering predicted subjective wellbeing and loneliness, above and beyond known sociodemographic predictors. Secondary data from 7146 adults from the Taking Part 2019–2020 survey (UK household survey of participation in culture and sport...

Antidepressant Effects of Lactoferrin-Modified Sodium Alginate-Based Saikosaponin A Nanogels via Intranasal Administration: Involvement of Olfactomedin-Family Proteins

Objective: To develop a lactoferrin-modified sodium alginate nanogel loaded with saikosaponin A (SA-Lf-NG@SAA) and evaluate its potential antidepressant-like effects following intranasal administration. Methods: SA-Lf-NG@SAA nanogels were prepared and optimized using single-facto...

Selective Lithium Pre-Leaching from Pyrolyzed Industrial Lithium-Ion Battery Black Masses Using Dilute Organic and Inorganic Acids

Selective lithium pre-leaching can separate an accessible lithium fraction before complete black-mass dissolution while limiting the co-dissolution of accompanying elements. However, comparative evidence across compositionally different, industrially pyrolyzed black masses under...

Effectiveness and Long-Term Side Effects Associated with Hormonal Therapy in Patients with Polycystic Ovarian Disease (PCOD)

ABSTRACTPolycystic Ovarian Disease (PCOD), commonly referred to as Polycystic Ovary Syndrome (PCOS), is aheterogeneous endocrine disorder associated with menstrual dysfunction, hyperandrogenic manifestations,metabolic abnormalities, reproductive difficulties, and psychological bu...

Health as a Decision Problem in BioCognitive Architectural Design: A Critical Review and Physiological–Regulatory Perspective

BioCognitive Architectural Design (BCAD) positions architecture as an active modulator of human biological and cognitive processes, yet the operational status of health within architectural decision-making remains unclear. Although evidence linking built-environment conditions to...

The Effects of Pyrite on Nitrogen and Phosphorus in Leersia hexandra Swartz Constructed Wetlands Under Cr(VI) Stress

The discharge of chromium-containing wastewater into natural aquatic systems poses a substantial risk to both ecosystem integrity and human health. In this study, a pyrite-amended Leersia hexandra Swartz (L. hexandra) constructed wetland was established to investigate the mechani...

Calibration Is Not Enough: An Anytime Monitor for Trustworthy Abstention

Version 2 (9 September 2026) — erratum. An independent audit found several statements in v1 that the paper's own logs and results did not support — stale prose from an earlier run of the same experiment, not a change to the method. Corrected: the batch baseline's overall answered...

Heart failure risk stratification using the HFA-PEFF scale in patients with arterial hypertension after COVID-19: the role of inflammatory status and identification of the most vulnerable group

COVID-19 survivors with hypertension exhibit an elevated risk of heart failure with preserved ejection fraction. The impact of systemic inflammation on the long-term functional prognosis of this patient demographic remains inadequately explored, particularly in individuals with i...

The impact of the COVID-19 national lockdown on acute coronary syndromes related hospitalization in Johannesburg, South Africa

Evidence from low- and middle-income countries (LMICs) on how COVID-19 lockdown measures affected acute coronary syndrome (ACS) care is limited. We assessed the impact of South Africa’s national lockdown on ACS hospitalisations and clinical severity at presentation at a large ter...

Structural origin of the strong effect of attraction on bulk viscosity in simple liquids

The effects of pairwise attraction and three-body interactions (Axilrod-Teller-Muto triple-dipole potential) on bulk viscosity, compared with shear viscosity, were investigated using molecular dynamics simulations, with particular focus on the underlying structural dynamics. Our...