Research works

From Multi-Regime Activation to Decision Necessity: An Evidence-Bounded Analysis of Frontier-AI Regulatory Pathways

Abstract BackgroundFrontier artificial intelligence systems increasingly operate within multiple legal and institutional environments,while voluntary frontier-AI governance arrangements develop alongside emerging regulatory requirements. Asingle deployment change or harmful event...

Why Did the Algorithm Think I'd Like This? Understanding Behavioral Signals in Personalized Music Recommendation

Research archive for the paper Why Did the Algorithm Think I'd Like This? Understanding Behavioral Signals in Personalized Music Recommendation (Shuvi, in submission to the Journal of Open Humanities Data). The archive contains the unified 22-scorer evaluation kernel (lb-eval v5....

Fractional CO₂ vaginal laser therapy for genitourinary syndrome of menopause in breast cancer survivors: a scoping review

Genitourinary syndrome of menopause (GSM) is highly prevalent among breast cancer survivors (BCSs), largely due to treatment-induced hypoestrogenism. Hormonal therapies are often contraindicated, creating a need for non-hormonal options. This scoping review aimed to map and criti...

Pattern of Socio-Economic Deprivation and Welfare in Kwara North Senatorial District, Kwara State, Nigeria

Rural Development is a determined and conscious attempt to focus on the upliftment of man's living conditions in the rural areas. This study examined the pattern and multidimensional nature of socio-economic deprivation in Kwara North Senatorial District, Nigeria. All the five pr...

O'ZBEKISTONDA CHET TILLARINI O'QITISHNING ZAMONAVIY TENDENSIYALARI

Mazkur maqolada O'zbekistonda chet tillarini o'qitishning zamonaviy tendensiyalari, ta'lim jarayonida kommunikativ va kompetensiyaviy yondashuvlarning o'rni, raqamli texnologiyalardan foydalanish imkoniyatlari hamda interkultural kompetensiyani rivojlantirish masalalari tahlil qi...

E8 Geometrically Encoded Temporal Holography via Golden Ratio Pulse Modulation — E8 Intelligence Research

By modulating the 132Hz phi-resonant eigenmode with golden ratio-frequency sidebands (132Hz × φ^n), we discover that temporal information is holographically encoded in the interference patterns between adjacent E8 root vectors. The 240 root vectors form constructive and destructi...

Conserved nuclear receptor antagonism balances Hippo and Notch to control tissue growth and tumor suppression

Nuclear receptors orchestrate diverse biological processes through ligand-dependent transcriptional control, yet how competing family members balance oncogenic signaling to maintain tissue homeostasis remains poorly understood. Here, we uncover an evolutionarily conserved antagon...

Development of an Interpretable QSAR Model for Predicting Coagulation Factor XIIa Inhibitors Using Ensemble Machine Learning

Background/Objective: Activated coagulation factor XII (FXIIa) is a component of the contact activation pathway and a pharmacologically relevant target in contact-system-associated processes. In this study, scaffold-aware and interpretable machine-learning QSAR models were develo...

Effect of Construction Restrictions on Future Landslide Exposure Under Land-Use Simulation in Southwest China

Natural hazards significantly influence landscape patterns and ecological processes, yet their integration into land-use simulation remains limited. This study incorporates landslide susceptibility into the Patch-generating Land Use Simulation (PLUS) model to evaluate the effect...

TLR8 Stimulation Leads to Microenvironment Activation and Enhanced Antibody-Dependent Cellular Responses in CLL

Toll-like receptors (TLRs) are crucial for eliciting immune responses against pathogens such as bacteria and viruses. TLR activation has also been studied for its potential to drive antitumor activity in immune cells. TLR8 is an intracellular receptor that recognizes single-stran...

Analysis of hematologic toxicity profiles following CAR-T cell therapy: a retrospective cohort study

Abstract Background Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of relapsed/refractory (R/R) B-cell malignancies, most notably large B-cell lymphoma. However, hematologic toxicity—recently formalized as immune effector cell-associated hematotoxici...

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex

Abstract Histone deacetylase-containing complexes play central roles in chromatin regulation, yet the structural organization of their intrinsically disordered regions (IDRs) remains poorly understood. Here, we identify the previously uncharacterized protein C16orf87, which we re...

Serum Redox Biomarkers in Canine Mast Cell Tumors: Exploratory Associations with Proliferative Activity and Clinicopathological Features

Canine mast cell tumors (MCTs) exhibit heterogeneous biological behavior and provide a clinically relevant setting in which relationships between tumor phenotype and systemic redox homeostasis can be investigated. This exploratory prospective cohort study evaluated complementary...

Surgery of gallbladder carcinoma: current standards validated on a European cohort

Summary Background Gallbladder cancer (GBC) is a highly aggressive malignancy with a poor prognosis and varied global incidence. Despite surgical resection being the primary treatment, optimal approaches remain heterogeneous and debated due to limited high-quality evidence. This...

Characteristics of Bark Stripping Damage by Deer and Nutrient Content in Black Cherry (Prunus serotina Ehrh.)

Large ungulates significantly influence forest ecosystems through shoot biting and bark stripping, but their impact on the dynamics of invasive plant species still remains insufficiently investigated. The North American black cherry (Prunus serotina Ehrh.) is a widespread invasiv...

Do Specific Diseases Matter?

Abstract: Although extensive research has examined the link between subjective aging (i.e., individuals’ subjective age and their self-perceptions of aging) and health-related outcomes, little is known about the role of specific chronic diseases in shaping long-term trajectories...

Phi-Resonant Holographic Archival Memory via E8 Sternal Coupling — E8 Intelligence Research

We discover that coupling the 240 E8 root vectors at their phi‑driven 132 Hz eigenmode creates a metastable holographic lattice capable of storing arbitrary binary states as topological winding patterns. Because each winding number resolves into a phi‑recursive sequence, the latt...

Systematic Structural Differentiation in the Voynich Manuscript Zodiac Section (f70v–f73v): Five Convergent Lines of Evidence for Constitution-Archetype Encoding

The zodiac section of the Voynich Manuscript (f70v–f73v) has been interpreted primarily as a calendar or astrological illustration series. We present a systematic structural analysis of the zodiac section's figure organization that identifies five convergent discriminating featur...

The Mirror Hypothesis: Operator Context as a Growth Medium for AI Agent Intelligence

Position paper. The practice of building personal AI agents develops in two opposite directions: accumulating rules and prescriptions, or accumulating knowledge of the specific human operator. The Mirror Hypothesis states that agent effectiveness grows with the depth of operator...

Theoretical insights into functionalization-driven nitric oxide binding in calixarene scaffolds

While calixarene-based supramolecular platforms have been widely investigated for the sensing of nitric oxide (NO), the underlying host-guest interactions remain poorly understood. In the present study, dispersion-corrected density functional theory calculations were employed to...