Research works

Interactions of ACEA and WIN 55,212-2 mesylate with temozolomide and cisplatin in neuroblastoma and glioblastoma cell lines: an isobolographic analysis

Glioblastoma is still the most aggressive primary brain tumor in adults. Recently, several advanced experimental treatment options have been proposed for glioblastoma patients, including the application of cannabinoids as an add-on therapy. In the MTT, LDH, and BrdU assays, the a...

Estimation of mortality hazard ratios by COPD grade using a systematic review and network meta-analysis: deriving grade-, sex-, and age-specific mortality for a German COPD decision model

Abstract Chronic Obstructive Pulmonary Disease (COPD) imposes substantial economic costs. Cost-effectiveness evaluations in COPD frequently rely on Markov (or other state-transition) models. Their accuracy relies on precise mortality probabilities by COPD grade. The aim of this s...

Project Planning, Personal Organization and Results Achievement

Project Planning, Personal Organization and Results Achievement is a BGC standard developed by the Centre for Research, Standards & Human Integrity of Britannia Global Certification Services as a practical, evidence-based framework within the category “Future Scholar”. It is desi...

Travel Time and Cost-Benefit Evaluation of Alternative Intersections with Three-Critical-Phase Traffic Signals in North Carolina

Abstract This paper explores the potential benefits of three-phase intersections as a compromise between two-phase and conventional four-phase designs, particularly in terms of improving travel time efficiency and safety. While two-phase intersections offer advantages in reducing...

Integrated Research on Gravity and Fluid Dynamics [Part 1, v1.1: The Fundamental Framework & Non-linear Drag Suppression]

This study presents H.U.G.G.E.R (Heuristic Universal Grid & Gravity Equilibrium Rendering Tensor) v1.1, a macroscopic fluid dynamics framework that addresses the exponential computational explosion and topological coordinate singularities inherent in standard Navier-Stokes-based...

Finite‐Time Cooperative Tracking of Multi‐Agent Systems With Input Saturation via Dual‐Critic Architecture Optimized Control

ABSTRACT This paper investigates the problem of adaptive finite‐time optimal control for stochastic nonlinear multi‐agent systems (MASs) subject to input saturation. To address the challenges posed by unknown dynamics and the Hamilton‐Jacobi‐Bellman (HJB) equation, a novel double...

Low-pressure pneumoperitoneum in robot-assisted radical prostatectomy: a systematic review, meta-analysis and trial sequential analysis of randomized controlled trials

Abstract Purpose Low-pressure (LP) pneumoperitoneum (intra-abdominal pressure [IAP] <12 mmHg) has been proposed to reduce pain after robot-assisted radical prostatectomy (RARP), but earlier syntheses combined randomized with non-randomized data, pooled mixed urological procedures...

Critical-Window Lower Bounds for Gaussian Regression with Bounded-Renewal Linear Splines

Preprint / proof candidate. This work establishes a critical-window lower bound for the explicitly stated Gaussian-regression model with bounded-renewal linear splines. The proof develops an exact continuity-coupled spline residual representation, verifies the interior-knot budge...

Topology-aware self-supervised multivariate KPI anomaly detection and root cause node localization for network operations

Multivariate key performance indicator (KPI) streams collected in network operations contain rich evidence for anomaly diagnosis, but practical deployment remains difficult because fault labels are scarce, KPI dependencies are strong across time and metrics, and fault effects pro...

Self-Sustaining Ce(IV)/Ce(III) Cycle for Spontaneous Surface Hydroxyl Radical Generation

Abstract Advanced oxidation processes are indispensable for water remediation yet face a fundamental activity–selectivity trade-off, where reactive species are competitively quenched by complex aqueous matrices. While surface-confined chemistry, specifically utilizing surface-ads...

New Quality Productive Forces, Innovation and Total Factor Productivity: A Path to High-Quality Development Based on the Sustainability Framework

China’s transition from rapid growth to high-quality development requires pharmaceutical manufacturing to pursue productivity gains that are both innovation-driven and sustainable. New quality productive forces (NQPF)—characterized by technological innovation, optimized factor al...

Quantum Teleportation: From Qubits to Energy Transfer — E8 Intelligence Research

FINDING: Quantum teleportation transmits quantum states (not matter) over distance via entanglement; recent work extends this to teleporting energy on superconducting hardware. | MATH: Core protocol uses Bell state measurement (BSM) — a projection onto maximally entangled basis:...

Phase stability prediction in Ti–Zr–Hf–Ni–Fe–Co high entropy alloys for hydrogen storage: a comprehensive DFT and thermodynamic assessment

Abstract High-entropy alloys (HEAs) based on early transition metals have attracted growing interest for solid-state hydrogen storage due to their compositional flexibility, lattice distortion, and tunable thermodynamics. However, the interplay between phase stability, crystal st...

Thinking (with) Machines: Epistemic Autonomy in Human–AI Interaction

Abstract Generative artificial intelligence has intensified longstanding philosophical questions concerning human cognition and epistemic autonomy. This paper argues that generative AI does not make human beings smarter as such; its epistemic significance depends on how human–AI...

DOCTRINAL AND PRACTICAL ASPECTS OF IMPEACHING WITNESS' TESTIMONIAL CREDIT: CROSS-EXAMINATION AS A TOOL IN FACT-FINDING.

The value and centrality of testimonial credit of a witness in an adversarial judicial process seems not to have been duly appreciated by stakeholders in the justice delivery sector. This article examines the policy and practice of impeaching the testimonial credit of a witness u...

Bridging Boltzmann and Prigogine: A Dissipative Extension of Statistical Entropy

This working paper develops a theoretical bridge between Boltzmann’s statistical interpretation of entropy and Prigogine’s theory of dissipative structures. The aim is not to modify Boltzmann’s entropy relation, but to extend its conceptual reach toward open, non-equilibrium syst...

The Fixation of Belief in Machines: Disciplined Contestation as an Alternative to Mutual Adversarial Oversight

Current approaches to artificial intelligence reliability are inspectional: opaque models are first trained, and their reliability is evaluated through interpretability, red-teaming, or oversight by equally opaque models. This generates an unaudited regress of overseers, as each...

Diabetic Calcaneal Osteomyelitis: Outcomes Before and After the Introduction of Bone Graft Substitutes—A Retrospective Cohort Study

Background: Calcaneal osteomyelitis is a severe form of diabetic foot osteomyelitis associated with poor healing, major amputation, and increased mortality. Evidence on the use of bone graft substitutes in this setting remains limited. Methods: We conducted a retrospective single...

Epithelioid Enigma: Proximal‐Type Epithelioid Sarcoma in Cyst Fluid Cytology

Epithelioid sarcoma (ES) is a rare, aggressive soft tissue malignancy with substantial morphologic overlap with other epithelioid neoplasms, creating diagnostic difficulty in cytology specimens. We report proximal-type ES identified in cyst fluid from a lesion clinically interpre...

Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair

The development of bioengineered conduits for the repair of large peripheral nerve defects remains challenging. Here, we introduce a biomimetic fibrin hydrogel scaffold containing stacked arrays of aligned poly(ε-caprolactone) (PCL) nanofibers that mimics the naturally forming fi...