Research works

Rewriting the cancer epigenome: CRISPR technologies for DNA methylation editing

Abstract Aberrant DNA methylation is a fundamental hallmark of cancer, characterized by widespread global hypomethylation, focal hypermethylation of key regulatory regions, and extensive disruption of gene regulatory and epigenomic networks. Despite comprehensive methylome profil...

Total factor productivity and profit growth in cotton production in Benin, West Africa

Understanding the sources of growth in total factor productivity (TFP) and profit is crucial to guide agricultural policy decisions. This study examines TFP and profit growth in cotton production in Benin between 2000 and 2018. Using panel data from 482 cotton producers, a parame...

Symbolic sex in polish folk plant taxonomy: the case of shrub names

Abstract This article examines the role of symbolic sex in Polish folk plant taxonomy, focusing on the cultural representations of three shrubs: guelder rose ( Viburnum opulus ), hazel ( Corylus avellana ), and juniper ( Juniperus communis ). Drawing on linguistic data (plant nam...

A data synthesis and comparative review of rainfall partitioning: Drivers and management implications in fruit crops

Rainfall partitioning, the redistribution of gross rainfall into canopy interception (Ic), throughfall (TF), and stemflow (SF), is a critical ecohydrological indicator governing water acquisition, soil water availability, and yield in fruit crops. Although studies in various clim...

Genesis Chrono-Geometry: Machian-Holographic Synthesis ofInertia, Topological Mass Evaporation, andInformation-Theoretic Origin of the Dark Sector

Title: The Genesis Theory: Field-Dependent Inertia and Public Disclosure Abstract This work presents a theoretical framework for the modulation of inertial mass through coupling to a hypothesized scalar field. The core postulate of the "Genesis Theory" is that effective inertial...

Note on principles of the three-body problem in gravitation and Lagrangian points

The three-body problem in gravitation is one of the oldest problems in celestial mechanics, having beenstudied since the end of the 18th century. Although there is no general closed-form solution to this problem,its analysis based on simplifications– as done by Lagrange and Euler...

A binomial precision method for compound interest

This document presents a simple method to calculate compound interest using binomial expansion. Unlike the standard formula, this approach lets you choose how accurate you want the answer to be by controlling the number of terms used. It also gives a clean, easy rule for deciding...

Thermodynamic analysis of a solar-powered hybrid polygeneration system using linear fresnel reflectors for multi-energy production

The rising need for sustainable energy solutions has further raised interest in solar-based multigeneration systems that can provide multiple useful products from a single renewable energy resource. In this paper, a linear Fresnel reflector (LFR) assisted hybrid polygeneration sy...

(Short Paper17) The Physical Inevitability of Sleep in the Biolog ical QPU Paradigm: Phase Noise Rejection and Autonomous Calibration of Absolute Coordinates

Sleep is a universal phenomenon observed across all life, yet conventional biochemical interpretations (e.g., removal of fatigue substances and maintenance of synaptic homeostasis) struggle to physically explain the fatal breakdown of spatial cognition (loss of depth perception a...

Context memory in younger and older adults: Insights from metacognition

Cognitive aging is characterized by a deterioration of episodic memory functions. Since episodic memory requires retrieval of context, it has been proposed that older adults suffer from a specific deficit in terms of remembering context associated with to-be-remembered informatio...

Comparative efficacy and safety of intra-articular versus intravenous tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis

Total knee arthroplasty (TKA) is frequently associated with considerable perioperative and postoperative blood loss, making tranexamic acid (TXA) a key component of modern blood-sparing protocols. Although both intravenous (IV) and intra-articular (IA) routes are widely used, the...

Breeding progress and climate adaptation in semi‑dwarf durum wheat: Genetic gains from long‑term multi‑environment trials under a Mediterranean environment

Durum wheat is a key cereal in Mediterranean agriculture, where productivity is challenged by climate change and yield stagnation. However, information on genetic gains after the introduction of Rht genes remains limited. This study quantified breeding progress and associated tra...

Bacillus subtilis extracellular vesicles surface-displaying superoxide dismutase attenuate alcoholic liver injury by activating the Nrf2/HO-1 axis

Alcoholic liver disease (ALD) represents a globally prevalent progressive hepatic disorder with continuously rising incidence. Its pathological mechanisms mainly stem from the direct toxic effects of alcohol metabolites, accompanied by aggravated oxidative stress, lipid overaccum...

Engineering an F-Amine Dehydrogenase for Efficient and Sustainable Biocatalytic Synthesis of a Chiral PDE10 Inhibitor Precursor

Abstract (R)–4-(1H-indol-3-yl)butan-2-amine ((R)-4IBA), encompassing a nitrogen heterocycle and a chiral primary amino group, is a highly appealing precursor in the pharmaceutical domain. The direct amination of the readily available prochiral ketone 4-(1H-indol-3-yl)butan-2-one...

Performance of an unmanned sailboat towing a sonar array system in various wind conditions

This paper proposes a novel unmanned sailboat towing a towed array sonar system (USTAS) and develops a framework for evaluating its speed performance in calm water under both steady and unsteady wind conditions. This study represents the first application of a previously develope...

Tracing metal sources in W-Sn deposits: Sr-Nd isotope geochemistry in wolframite, scheelite, and cassiterite from the Iberian Variscan Massif, Spain and Portugal

Abstract This study presents new TIMS Sr and Nd isotopic analysis of cassiterite, wolframite and scheelite from nine W-(Sn) and six Sn-(Ta-Li) vein-type deposits in the Iberian Variscan Massif, with the aim of constraining the source of metals in these deposits. Scheelite display...

The hypoxia–gut microbiota–bile acid axis: mechanistic crosstalk and therapeutic opportunities

Hypoxia is a central feature of a wide range of pathological conditions; however, the metabolic regulatory networks underlying hypoxic adaptation remain incompletely understood. In recent years, accumulating evidence suggests that bile acids, traditionally regarded as metabolic e...

Guidelines for workplace vigilantes: the influence of punishment altruism and gender on bystander behavior

Purpose Workplace vigilantes are individuals who monitor and punish deviants without formal authority. This study aims to examine how punishment altruism and workplace vigilante gender influence bystander behavior. Design/methodology/approach Drawing on the cognitive appraisal th...

Comparative genomics reveals genotype-phenotype concordance and cryptic resistomes in clinical Pseudomonas aeruginosa

Abstract Background Pseudomonas aeruginosa (P. aeruginosa) is a major pathogen because of its adaptability. It shows rapid evolution of multidrug resistance (MDR). Phenotype-based diagnostics often fail to detect silent resistance determinants and early adaptive changes. This stu...

Plant growth-promoting microorganisms enhance maize performance under salinity stress: a comprehensive meta-analysis of morphological, physiological, and biochemical responses

Salinity stress severely limits global maize ( Zea mays L.) productivity by disrupting plant growth, physiology, and yield formation. Plant growth-promoting microorganisms (PGPMs), including bacteria and mycorrhizal fungi, have been widely investigated as sustainable tools for im...