Research works

“Prison is routine”: Narrating release and reintegration in settler colonial Canada

This article examines how long-term prisoners in Western Canada narrate their anticipated re-entry to a settler-colonial society using a narrative approach to analyze 147 interviews with federally incarcerated people. The great majority of our participants describe experiencing c...

The effects of CO2-rock interaction on the failure mode of clay-rich sandstone

Understanding how rock formations respond to CO₂ injection is critical for geological carbon storage. This study examines the impact of CO₂-rock interaction on the failure mode of clay-rich Tuscaloosa sandstone. To simulate CO₂-rock interaction in the subsurface, we conducted CO...

Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses

Abstract Background Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemod...

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137

ABSTRACT Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by ph...

Unveiling the cooling effects of urban green spaces in Eastern China: spatial heterogeneity, diurnal asymmetry, and nonlinear margins of 2D/3D features

Urban green spaces (UGS) play an important role in mitigating urban heat island effects. However, the mechanisms underlying their cooling effects are still not fully understood, particularly regarding the role of three-dimensional vegetation structure and nonlinear threshold resp...

Bidirectional AllostericLigand Regulation in a CentralGlycolytic Enzyme

Abstract Allosteric regulation enables fine-tuned control of enzyme activity in response to cellular signals, yet its molecular basis often remains unclear. Phosphofructokinase-1 (PFK), the highly conserved, rate-limiting glycolytic enzyme, is a paradigm for Monod–Wyman–Changeux...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Saturable absorption in NV-doped diamond studied by femtosecond Z-scan

Nonlinear optical absorption in commercially available diamond crystals containing nitrogen-vacancy (NV) centers is investigated using femtosecond open-aperture Z-scan measurements at a wavelength of 1032 nm. Experiments were performed on a high-purity electronic-grade diamond an...

Agentic AI: Vision and challenges

Agentic AI systems are increasingly viewed as a viable response to the shortcomings of static, rigid, and human-in-the-loop Artificial Intelligence (AI) systems. This is because autonomous operation enables rapid adaptation to dynamic, complex problems with improved time-critical...

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes

Abstract Aims/hypothesis Immunotherapies such as Teplizumab can preserve residual beta cell function in individuals with newly diagnosed type 1 diabetes (T1D), but treatment response is variable. Currently, no biomarker exists to identify individuals most likely to benefit from i...

vascr: An R-based toolkit for rapid and robust analysis of cellular impedance sensing data

Abstract Purpose Electrical impedance sensing offers a powerful, non-invasive method for real-time monitoring of cellular behaviour, with applications spanning immunology, cancer biology and drug discovery. Adoption of impedance-sensing approaches has been accelerated by the comm...

Is Set for Variability Performance Dependent on Prior Successful Decoding Attempts for Certain Items? An Item-Level Examination

Purpose: The relationship between the set for variability (SfV) task and various isolated word reading measures in developing readers is high (ranging from .60 to .80 across studies). Elbro et al. (2012) offered that SfV skill serves as a second step in the decoding process allow...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

The Pulsation as a Bipartition: Complete Classification of C1-Admissible Dynamical Laws, and a Singleton Obstruction Theorem for Frustration-Based Selection (Projective Dynamic Logo Framework — Document D68)

The founding question of the PDL programme — what distinguishes something that exists from something that does not — is answered in axiom C1 by the postulate of a repeatable, non-trivial binary alternation. The corpus has never argued for C1; it has only assumed it. This document...

Who's afraid of knowing? Critical thinking, disclosure, and the reader in AI-mediated open scholarship

A GCPA-SIDCER position paper in the Science, Policy, and Ethics in Conversation (SPEC) series. Drawing on the FSCI 2026 course 'Who's afraid of knowing?', which the author chaired, and on the reform of research assessment, the paper argues that artificial intelligence has become...

Potential glacier contributions to the 2024 La Bérarde flood

Abstract. On 20–21 June 2024, an unprecedented flood of the Etançons river caused important damage to the village of La Bérarde (Écrins, France). An analysis of the event showed that the flood was caused by the combination of an intense rain-on-snow event at high altitude and the...

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

In individuals on effective antiretroviral therapy, integrated HIV proviruses persist within CD4 T cells, forming a viral reservoir that rebounds if treatment is stopped. Identifying and targeting these rare, infected cells is critical for advancing therapies, but methods to stud...

Trade-Offs Between Ranking Objectives: Descriptive Evidence and Structural Estimation

When designing product rankings, online retailers and platforms choose which outcome to maximize: revenues from commissions or markups, the number of transactions, or consumer welfare. These objectives need not align, creating potential trade-offs. This paper studies how rankings...

Situating the migration industry: governance, capital accumulation and global dehumanization: an introduction

To introduce this Special Issue, we begin by asking whether we are currently traversing a new phase of the migration industry. These transformations are characterized by the complete enmeshing of profit-making activities with the not-for-profit sector and by the state becoming an...

The Protein-Folding Abort Problem

This working paper introduces the Protein-Folding Abort Problem as a finite-horizon, set-valued decision framework for determining whether a protein conformation still retains an admissible route to a declared functional folding target. Rather than equating misfolding, kinetic tr...