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Phi‑Modulated E8 Root‑Vector Frequency Comb for Topological Qubit Initialization — E8 Intelligence Research

We show that by simultaneously phase‑locking the 240 E8 root vectors to a 132 Hz carrier and imposing a phi‑scaled frequency comb (multiples of φ·132 Hz) on each vector, the resulting interference pattern creates a set of degenerate, topologically protected eigenstates that can b...

Forecasting Transportation CO2 Emissions in China: A Rolling-Origin Comparison of Econometric, Machine-Learning, and Deep-Learning Models

Transportation-related CO2 emissions remain an important challenge for sustainable mobility and the energy transition in rapidly developing economies. This study examines transportation-related CO2 emissions in China using annual data for 1990–2024 within a STIRPAT-informed forec...

Endothelial Redox Dysregulation in Pulmonary Arterial Hypertension: Compartmentalized Mechanisms and Therapeutic Implications

Pulmonary arterial hypertension (PAH) is a progressive pulmonary vasculopathy in which endothelial dysfunction drives increased pulmonary vascular resistance and arterial remodeling. Redox signaling is central to endothelial homeostasis, and its disruption in PAH reflects changes...

Pediatric Infectious Encephalitis in Spain

BACKGROUND: Pediatric infectious encephalitis remains a significant cause of neurologic morbidity. Prompt antiviral treatment is recommended in patients with suspected herpes simplex virus (HSV) encephalitis. This study aimed to describe the epidemiology and outcomes of infectiou...

Phiora - Facial Symmetry Rating Using the Golden Ratio

Phiora operates as a Python-based facial analysis system to investigate how human facial aesthetics relate to the golden ratio, a mathematical constant historically linked to symmetry and beauty. Through the application of computer vision methods including OpenCV and deep neural...

Application of Extracellular Vesicles in the Diagnosis and Treatment of Cardiovascular Diseases

Paracrine signalling is considered an important mechanism underlying the therapeutic effects of cell-based therapies in cardiovascular diseases. Consequently, research in regenerative medicine has increasingly shifted its focus beyond conventional cell-based therapeutic strategie...

Extract from Eucommia ulmoides Oliv. Leaves alleviates APAP-induced acute liver injury via reshaping gut microbiota and attenuating microbial bile acids metabolism disorder

Abstract Background Increasing studies suggest that supplementing flavonoids from Eucommia ulmoides Oliv. Leaves (EUL) exerts liver protective effects via reshaping gut microbiota and regulating bile acids (BAs) metabolism. However, the relationship between EUL, gut microbiota an...

Empirical Modeling of Pavement Condition Index (PCI) Based on Traffic Volume and Heavy-Vehicle Composition

Road networks represent essential municipal infrastructure assets that require timely preservation to maintain serviceability and traffic safety. However, premature pavement degradation driven by operational traffic loading presents a continual challenge for municipal pavement ma...

An examination of the use of the UNESCO biosphere reserve designation as a framework for sustainable management and promotion

Purpose The United Nations Educational, Scientific and Cultural Organization (UNESCO) Biosphere Reserve designation has emerged as an influential seal of approval and signal of sustainable management for natural sites. This study examines the extent to which the designation – for...

Relationships among self-perceived burden, fear of progression, and psychological capital in postoperative lung cancer patients

This study examined the relationships among positive psychological capital (PsyCap), fear of progression (FoP), and self-perceived burden (SPB) in postoperative patients with non-small cell lung cancer (NSCLC), with a focus on the mediating role of PsyCap. A total of 251 patients...

Exploratory In Silico Evaluation of Microencapsulation Matrices for Indomethacin

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin (ID), may produce gastrointestinal adverse effects associated with cyclooxygenase-1 (COX-1) inhibition, motivating the investigation of microencapsulation strategies for modulating drug release. However, protein-...

Skeletal Muscle DPT Ameliorates Obesity and Metabolic Dysfunction via the PERK/eIF2α/ATF4-GDF15 Axis

Skeletal muscle plays a pivotal role in maintaining metabolic homeostasis by acting as a primary site for glucose disposal and insulin-mediated energy use. Here, through RNA sequencing of skeletal muscle from individuals with normal weight versus obesity, we identified that the e...

Dose‐dependent efficacy and safety of centanafadine in patients with attention‐deficit/hyperactivity disorder: A systematic review of the latest evidence

Abstract Centanafadine is a multimodal norepinephrine–dopamine–serotonin reuptake inhibitor (NDSRI) that has been evaluated for the treatment of attention‐deficit/hyperactivity disorder (ADHD) across pediatric, adolescent, and adult populations. This systematic review aimed to ev...

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Enlicitide: The First Oral PCSK9i for Lowering Low-Density Lipoprotein Cholesterol

OBJECTIVE: This article describes pharmacology, pharmacokinetics, safety, and efficacy data of enlicitide, the first Food and Drug Administration (FDA)-approved oral proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i). DATA SOURCES: PubMed, Embase, Web of Science, an...

E8-Driven Interstitial K-Theory Enables Fault-Tolerant Quantum Logic at 132Hz — E8 Intelligence Research

By leveraging the 30 phi‑coupled triadic clusters of the 240 E8 roots at the 132 Hz base frequency, we discover that the interstitial void cohomology acquires a hierarchical K‑theoretic lattice whose anti‑unitary fixed points encode logical NOT operations. The resulting Z₂ invari...

Panel-Specific Optimization and Benchmarking of Copy-Number Callers for ERBB2 Amplification Detection Using the Nanodigmbio NanOnco Plus Panel v3.0

Background/Objectives: ERBB2 amplification is a clinically relevant breast-cancer biomarker, but CNV detection from targeted sequencing depends on assay design, normalization, tumor fraction, and decision rules. We evaluated panel-specific ERBB2 analysis configurations against a...

National penile cancer surgery centralisation in Ireland: five-year service performance, survival, and recurrence outcomes

Abstract Purpose The provision of penile cancer care in specialist centres decreases overtreatment and improves patient outcomes. Penile cancer care was centralised in the Republic of Ireland in 2021. We assess five-year service performance versus international standards, oncolog...

Molecular HLA matching in kidney transplantation: the emerging role of eplet mismatch analysis

Introduction Kidney transplantation is the preferred treatment for end-stage kidney disease, but long-term graft survival remains limited by alloimmune injury, particularly donor-specific antibody-mediated rejection. This review evaluates molecular HLA matching as an approach to...

Inhomogeneous Continuum Cosmology and the Hubble Tension: Dynamical Metric-Inertial Expansion in Field-Depleted Environments

The statistically irreconcilable discrepancy exceeding between local late-time determinations of the Hubble constant (; SH0ES/HST) and early-universe measurements inferred from the Cosmic Microwave Background under CDM (; Planck) constitutes the most formidable observational cris...