Research works

Centennial Celebration of the Fluids Engineering Division (FED)

Abstract Technology development accelerates economic growth and advances human life. As the Fluids Engineering Division (FED) of the American Society of Mechanical Engineers (ASME) marks its 100th anniversary, we review here the Division's achievements over the years and discuss...

8.8 Mercury Perihelion Precession

This paper derives the Mercury perihelion precession from the electron ground-state vacuum perspective. The relative gradient is defined as the intrinsic driving force of geometric gravity, and is a purely geometric constant. The precession coefficient is an algebraic identity —...

Deploying a Fully On-Premises Retrieval-Augmented Assistant over Proprietary Equipment Documentation in a Manufacturing SME

Small and medium-sized manufacturers hold much of their operational knowledge in proprietary equipment documentation — service manuals, standard operating procedures (SOPs), and maintenance bulletins — that original equipment manufacturers distribute under terms that discourage o...

Thrombophilia-related gene variants may be linked to polycystic ovary syndrome susceptibility and its related traits

Background Polycystic ovary syndrome (PCOS) is a prevalent endocrinopathy in reproductive-aged women having both gynecological and metabolic comorbidities. PCOS increases the risk of cardiovascular and thromboembolic diseases due to heightened prothrombotic states, suggesting sha...

Genetic diversity, haplotype structure, and population dynamics of Echinococcus granulosus isolates from human cystic echinococcosis in Tibet, China

Cystic echinococcosis (CE) is a globally important zoonotic disease caused by the larval (metacestode) stage of Echinococcus granulosus (sensu lato), a parasite complex characterized by marked genetic heterogeneity across geographical regions. The Tibet Autonomous Region (TAR) of...

Probiotic-hydrogel systems for microbiome-associated diseases: design principles, preclinical evidence, and translational challenges

The human microbiome provides a robust ecosystem for mucosal barrier function, immune regulation, metabolism, and resistance to pathogen infection. Dysbiosis causes inflammatory bowel disease, oral inflammation, wound damage, skin disease, and cancer-related immune dysregulation....

CRYPTO EVOLVER APPLIED — 2026-07-23 10:24 UTC — 0 avoided / 0 focused — E8 Intelligence Research

The MEMECOIN crypto team analysed live GTX crypto outcomes and APPLIED these filters to strategy_filters.json (enforced by gtx_autonomous and the meme tracker): Rule: avoid <= 20% WR, focus >= 55% WR, min 15 resolved setups. Author: Andrew Stewart Caldin, Independent Researcher,...

“You have to sell them as much as they’re trying to sell you”: U.S. Local Television News Directors’ Perspectives on the Struggle to Hire Reporters and Producers

This qualitative study examines hiring difficulties in local television (TV) news in small and medium TV markets (DMA #30+). The results of in-depth interviews showed that most interviewed news directors experienced talent shortages in their markets and had fewer and less prepare...

Distinction, Execution, and Adjudication

This paper introduces DEA (Distinction, Execution, and Adjudication), a governance architecture for LLM-assisted scientific workflows. DEA separates the authority to define a scientific transition, the capability to execute it, and the authority to adjudicate its result. The fram...

An identification of three constructions of one lattice, with the closed transverse trace as its lock (Geometry of the vacuum, floor −1)

A cell of d+1 unit directions with pairwise Gram -1/d arises by a representation-theoretic route (irreducibility of the standard representation of the symmetric group on d+1 letters, then Schur), with no energy, no Hamiltonian and no minimization anywhere in the chain; the single...

Cervicovaginal zinc and copper profiles across vaginitis phenotypes and hydrogel assignment: an exploratory pilot study

Abstract Zinc (Zn) and copper (Cu) support epithelial integrity, nutritional immunity, and host–microbiome interactions, yet cervicovaginal trace-metal dynamics across vaginitis phenotypes remain poorly defined. We prospectively quantified cervicovaginal lavage (CVL) Zn and Cu by...

DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL TABLETS OF ONDANSETRON FOR BUCCAL DRUG DELIVERY

Ondansetron is a widely used antiemetic drug for the prevention and treatment of chemotherapy-induced, radiotherapy-induced, and postoperative nausea and vomiting. However, its oral administration is associated with limitations such as first-pass hepatic metabolism, gastrointesti...

A fragment-based model and annotation environment for discontinuous and overlapping terms

Abstract Terminology and entity annotation tasks in digital-library and corpus-oriented workflows often involve expressions that are discontinuous, overlapping, or partially shared. While several existing annotation environments support span-based and relation-based annotation, d...

SUSTAINABLE ENVIRONMENTAL GOVERNANCE IN THE LIGHT OF ISLAMIC LAW AND MODERN POLICY PRACTICES: A NIGERIAN CONTEXT

The rising ecological crises in Nigeria – ranging from deforestation, water pollution, and desertification to oil spills and unregulated waste disposal – present significant governance challenges that require multidimensional approaches. While modern environmental policy framewor...

8.13 Fractal Hierarchical Universe

This paper extrapolates the structural constants at the atomic scale to statistically correlated hierarchies at the cosmological scale. Based on the ℳ𝒞ℐ three-sector structure and the seven-level recurrence, we derive: the fractal dimension holds universally for any scale factor;...

3.6 Photon Zero-Mass Theorem

This article proves that the photon mass is strictly zero—— is an algebraic necessity of the Coding Orbit, without introducing gauge symmetry as a postulate. The photon corresponds to the dominant Eigenvalue of the ℳ sector self-coupling and does not participate in the breathing...

Lupus Double-Negative B Cells Harbor Expanded Somatic Mutations in Lymphoma-Relevant Pathways

Objectives Systemic lupus erythematosus (SLE) patients have a 2–7-fold increased risk of hematologic malignancies, particularly B-cell non-Hodgkin lymphoma (B-NHL).[1] Although germline susceptibility shared between SLE and B-NHL is minimal,[2] somatic evolution of autoreactive B...

LAB #427 PROMISING: TG AUTO: EDGE MINER: 4 claimed edges pulled from the queue to the bench — E8 Intelligence Research

IDEA: AUTO-FORWARDED from the Telegram/breakthrough stream (#596604, division=platform, agent=edge_miner): exp#420 <- bt#596504: ICT Killzone London Open Breakout with ATR Targets [+10.2R over 549 trades on EURUSD 30m, 21% win rate, 1:3 R:R] exp#421 <- bt#596225: XAUUSD LONG-only...

Targeting RPRD1B overcomes chemoresistance in gastric cancer by suppressing the TOPBP1-mediated DNA damage repair pathway

Abstract Background Despite the widespread adoption of 5-fluorouracil (5-FU)-based regimens as first-line therapy for gastric cancer, a substantial number of patients develop innate or acquired resistance, highlighting the critical need to identify its underlying molecular driver...

EuroMillions Breakthrough Mining — 948 Sources, 4925 Leads Extracted — E8 Intelligence Research

Mined 948 lottery+quantum breakthroughs. Extracted 4925 leads across 13 categories. 3124 high-value leads found. Categories: {"CORRIDOR": 367, "FORMULA": 226, "GEOMETRIC": 634, "FORWARD_ATTEMPT": 381, "QUANTUM": 596, "TIMING": 160, "CELESTIAL": 311, "GEMATRIA": 344, "CONSTANT": 3...