Research works

Evaluating the Impact of Clonidine and Midazolam Premedication on Emergence Delirium in Pediatric Patients

BACKGROUND: adrenoceptor agonists, such as clonidine, have gained popularity for their sedative and analgesic properties. The effect of these agents on the incidence of emergence delirium remains uncertain. This study evaluated whether premedication with clonidine or midazolam is...

Prime-Based Encryption Using the Attractor Coordinate System: A Novel Cryptographic Framework with Post-Quantum Potential

We introduce a novel encryption framework based on the attractor coordinate system,originally developed for proving the Collatz and Twin Prime conjectures. Thesystem uses the unique representation of numbers n ≡ 7 (mod 8) asn = Aj + 2x = Aj+1 − 2y, x + y = 22j−1.This representati...

IgG4-Related Skin Disease in a 9-Year-Old Patient: Remission Under Mycophenolate Mofetil After Rituximab Failure

Background IgG4 related disease (IgG4-RD) is a systemic immune-mediated disease characterized by inflammation and fibrosis of nearly any organ.[1] This condition is rarely reported in children and especially with cutaneous involvement. We report the case of IgG4 related disease i...

The Mediating Role of Self-Compassion in the Relationship Between School Climate and Social Adaptation: A Latent Growth Modeling Approach

This study explores the links between school climate, self-compassion, and social adaptation among Chinese secondary vocational students, focusing on self-compassion’s mediating role. A three-month longitudinal study ( N = 333; 33.3% male) with one-month intervals revealed downwa...

From Ocean Dynamics to Plural Normative Orders Stratification, Localised Mixing, and the Governance of Interfaces: A Preliminary Discussion with Multilingual Democracy and International Organisations as Cases

A polity holding several orders of value contains parties whose claims are checkable on different time scales and by different observers, and arrangements of that kind are commonly assessed by measures computed on the whole. This paper takes the ocean as a worked case of a system...

STOS: A Biomimetic Cognitive Architecture for Self-Evolving LLM Agents

Large Language Model (LLM) agents demonstrate remarkable capabilities but struggle with self-evolution the ability to autonomously improve their own cognitive architecture through experience. We present STOS (Seek Truth OS), a biomimetic cognitive architecture that enables self-e...

STUDIES ON THE BACTERIAL COMMUNITIES ASSOCIATED WITH COCKROACH (Periplaneta americana) SAMPLED FROM INDOOR SPACE AND THEIR ANTIBIOTIC RESISTANCE

Indoor cockroaches are potential carriers of pathogenic and antibiotic-resistant bacteria. This study examined bacteria present on the external surfaces of Periplaneta americana collected from indoor environments in Malappuram District, Kerala, India, and evaluated their antibiot...

5.7 Doeblin-Type Upper Bound for Information Field Cumulants

Based on (Graph-Theoretic Definition of Information Field Cumulants), this article constructs a **Doeblin-type coupling** on the graph , jointly exploiting Birkhoff mixing () and hard-direction Lyapunov contraction (), to rigorously prove the exponential decay upper bound for the...

Acyl-Alkyl-Phosphatidylcholine C40:6 is Potentially a Causal Biomarker for Obesity-Related Knee Osteoarthritis: Data from 4 Independent Cohorts

Objectives To identify potential causal biomarkers for obesity-related knee osteoarthritis (OB+OA+) by metabolome-wide association analysis (MWA) and Mendelian randomization (MR). Methods Four cohorts were included: the Newfoundland Osteoarthritis Study (NFOAS) as discovery, the...

Defining Difficult-to-Treat Rheumatoid Arthritis in Routine Care: Comparative Performance of Published Criteria and Description of Early and Late D2T-RA Phenotypes

Objectives Despite advances in treat-to-target strategies, a subset of rheumatoid arthritis (RA) patients remains refractory to therapy, described as difficult-to-treat RA (D2T-RA). The European Alliance of Associations for Rheumatology (EULAR) has proposed formal criteria for D2...

Global Capital Meets Gender Diversity: A Study of Cross-border VC and PE Investments in Women-led Startups Across Emerging Markets

This study investigates the intersection of global investment flows and gender inclusion by analyzing cross-border venture capital (VC) and private equity (PE) investments in women-led startups across emerging markets, with a particular focus on India. Despite increasing internat...

Repeated Renal Interventions for Renal Cell Carcinoma in von Hippel-Lindau Disease: Long-Term Outcomes

Von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome frequently associated with recurrent renal cell carcinoma (RCC), often requiring multiple renal interventions. Data on the timing and outcomes of repeated renal procedures remain limited. This study aimed to characte...

The influence of MoS 2 lubricity on the secondary cutting performance of PCD micro-groove textured tools

Micro-textured cutting tools possess unique advantages in reducing cutting forces, lowering chip temperatures, minimizing tool wear, and improving machined surface quality. Nevertheless, the secondary cutting effect induced by micro-textures impairs texture integrity and aggravat...

Gothic Black Feminist Interventions: The Dilapidated American Mansion and Other Peculiar Rites

Black womxn's endurance of the American Gothic is distinct—one filled with corporeal violence, blood-thirsty systems, and haunting histories—thus, their healing requires the development of an equally attuned Gothic approach. Gothic Black feminism is an emerging theory that consid...

Beyond the detector trap: a human-centred evidentiary framework for fair academic integrity decisions in the generative AI era

Generative AI (GenAI) and large language models have disrupted traditional assumptions about academic writing, authorship, and assessment in higher education. While institutions often rely on AI-detection tools, this approach risks a detector trap: reducing complex academic integ...

A Unified Multi-Channel Phishing Detection Framework Using Machine Learning and Rule-Based Threat Analysis

Phishing attacks continue to evolve across multiple communication channels including emails, SMS messages, URLs, and websites. This paper presents a unified phishing detection framework that combines machine learning and rule-based threat analysis to identify phishing attempts ac...

10.15 Material Realm Contraction Time

We establish sublayer spectral analysis, three-dimensional volume traversal scaling, and holographic reconstruction construction, deriving the material realm contraction time, the cosmic radius, and the purely geometric spatial measure. Core results: cosmic radius billion light-y...

Opioid-induced respiratory depression or oversedation risk assessment in hospitalized patients with cancer receiving palliative care

Purpose The Oversedation Risk Criteria (ORC) is a prediction model that estimates prescription opioid-induced respiratory depression (OIRD) or oversedation risk in hospitalized patients. The study objectives were to estimate OIRD/oversedation risk via the ORC and to determine the...

Bricklaying Machine

This document presents a conceptual design for an automated brick- and block-laying machine intended to reduce physical strain on human masons while improving placement accuracy, repeatability, and construction speed. The system integrates a sectionized traction-belt saddle chass...

Celebrity Advocacy and the Politics of Insecurity in Nigeria: A Discourse Analysis of the Davido-Rarara Controversy

In June 2026, Nigerian Afrobeats singer Davido (David Adeleke) created a controversy when he appeared at the FIFA World Cup 2026 Countdown Concert in Los Angeles wearing a jacket with the slogan "Bring Them Home" and the names of thirty-nine (39) schoolchildren and seven (7) teac...