Research works

Tranexamic acid in primary total knee arthroplasty: a systematic review and meta-analysis of blood loss, transfusion, and deep vein thrombosis

Tranexamic acid (TXA) has been widely used in primary total knee arthroplasty (TKA) to reduce perioperative blood loss, but the pooled evidence regarding blood loss, transfusion, and deep vein thrombosis (DVT) remains to be further clarified. The purpose of this meta-analysis was...

Mapping reproductive healthcare needs of incarcerated women: a scoping review

The increasing female prisoner population worldwide highlights the urgent need for tailored reproductive healthcare services in correctional facilities. However, there remains a significant gap in comprehensively understanding and addressing the unique reproductive healthcare nee...

Progress, challenges, and future directions of pancreatic cancer surveillance in high-risk populations

Pancreatic cancer remains one of the most lethal malignancies because most patients are diagnosed with advanced disease, when curative treatment is rarely possible. Population-wide screening is not currently recommended because pancreatic cancer remains relatively uncommon. Early...

Central role of vapBC toxin–antitoxin system expression in the pathogenicity and antimicrobial resistance of Shigella sonnei isolates from pediatric diarrheal patients

Shigella sonnei , a Gram-negative bacterium, has been identified as a primary causative agent of gastrointestinal disease in humans. Antibiotic resistance has emerged as a critical concern in the context of Shigella species, thereby complicating the effective treatment of shigell...

Trends and fluctuations in technical performance in the 2010–2022 FIBA women’s basketball world cup

This study selected the quarterfinals, semifinals, and finals of the FIBA Women’s Basketball World Cup in 2010, 2014, 2018, and 2022, totaling 32 games, and aimed to examine the trends, fluctuations, and differences in technical performances of the Women’s Basketball World Cup fr...

Surgical strategies for external auditory canal cholesteatoma based on the He staging system: a retrospective study

PURPOSE: To investigate individualized surgical treatment strategies and clinical management experience for external auditory canal cholesteatoma (EACC) based on the He staging system. METHODS: Clinical data from 59 patients (61 ears) with EACC who underwent surgical treatment at...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...

Associations of key diet-quality indexes with trajectory of multimorbidity: a prospective study in the UK Biobank

Dietary patterns have been associated with the morbidity and mortality of individual non-communicable diseases(NCDs). However, the impacts of baseline dietary patterns among the initially healthy population on the progression from healthy to first non-communicable disease (FNCD),...

Articulating Hem-o-Lok–assisted single-position laparoscopic nephroureterectomy for UTUC: a feasibility study with preliminary oncological outcomes

Radical nephroureterectomy (RNU) with bladder cuff excision is the standard treatment for high-risk non-metastatic upper tract urothelial carcinoma (UTUC). This feasibility-oriented study aimed to describe articulating Hem-o-Lok–assisted single-position laparoscopic nephrouretere...

Effect of motivational interviews and peer education on adherence to pre-exposure prophylaxis among key populations in Kisangani: a randomized clinical trial

The present study aimed to evaluate the effect of motivational interviews and peer education on adherence to pre-exposure prophylaxis (PrEP) among key populations in Kisangani. This study utilizes a randomized controlled trial design to assess the effect of motivational interview...

Learning a unified graph transformer with mamba-based dynamic state evolution for 3D multi-object tracking

Abstract 3D multi-object tracking is crucial for autonomous driving, providing environmental sensing. To enhance multi-type tracking cues, we introduce DUG-Track (Dynamic Unified Graph Tracker), a novel tracker that pioneers a deeply integrated framework of dynamic state evolutio...

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology

Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently explored. Here, we show that mechanical fo...

Development of a teacher-delivered, school-based mental health promotion programme for adolescents in China: a Delphi study

Strengthening social and emotional competencies (SECs) is a promising upstream strategy for adolescent suicide prevention. However, the existing school-based programmes cannot be directly transplanted into the Chinese school environment. It could be attributed to the different ps...

Factors associated with prolonged hospital stay in mandibular condylar fractures: a multicenter retrospective study in Indonesia

Mandibular condylar fractures constitute a significant proportion of maxillofacial trauma and are associated with functional impairment and increased healthcare utilization. However, factors associated with the duration of hospital stay remain insufficiently understood, particula...

First detection of Leishmania infantum in dogs and wild-caught Culicoides oxystoma in Hainan Province, Southern China

Leishmaniases are neglected parasitic diseases expanding globally. In China, Leishmania infantum , which isendemic in the west, has reemerged and spread to the central part of the country, raising concerns about further potential expansion. Given limited data from southern China,...

Sustainable ammonia synthesis from nitrate wastewater via graphdiyne Mo–Cu–C≡C interfaces

Electrochemical green ammonia (NH3) production using renewable electricity is sustainable but suffers from selectivity-activity-stability trade-off under industrial conditions. Here we report an atomic interface engineering strategy enabling in-situ assembly and coupling of hexae...

Consent: Doctor, can you please do my operation?

The evolution of informed consent Globally, despite extensive written guidance, landmark legal cases, and evolving clinical practices, the landscape of informed consent remains uncertain for both patients 1 and doctors. 2 The notion of informed consent was thrust upon medicine by...

Development of an ethical resolution process and education resources: supporting equity-focused public health ethics education through community-engaged research

Healthcare ethics education is essential for supporting trainees and health professionals to build ethical reasoning skills necessary to resolve complex ethical issues, support equitable health outcomes, and promote just healthcare systems. Traditional ethical decision-making fra...

A NEW MORE ACCURATE HILBERT-TYPE INEQUALITYINVOLVING ONE PARTIAL SUM

By using the weight coefficients, the Euler-Maclaurin summation formula and Abel summation by parts formula, a new more accurate Hilbert-type inequality with the power function as the internal variables involving one partial sum is given. The equivalent conditions of the best val...

Exploratory Assessment of Ionic Liquid-Based Molecularly Imprinted Polymers for Potential Acrylamide Binding from Coffee Beverage

Acrylamide (AA) is a heat-induced process contaminant of toxicological concern associated with potential health risks. Its selective removal from complex food matrices, such as coffee brew, while preserving quality, remains a major technological challenge. This study explored an...