Research works

Community perceptions of primary health care in Oyo State, Nigeria: a cross-sectional study

Primary Health Care (PHC) is central to achieving equitable and cost-effective health systems, yet its potential in Nigeria remains underutilised. Despite the extensive network of PHC centres in Oyo State, utilisation remains low, partly due to misconceptions about PHC functions...

Advancing boundary-layer physics via Doppler wind LiDAR dynamic-thermodynamic profiling

Simultaneous, high-resolution measurements of boundary-layer dynamics and thermodynamics remain a longstanding observational challenge. We present a Doppler wind LiDAR–based retrieval that derives virtual potential temperature from TKE-budget buoyancy residuals, enabling concurre...

LGALS1 promotes gastric cancer progression and is associated with epithelial-mesenchymal transition and tumor immune microenvironment features

Galectin-1 (Gal-1, encoded by LGALS1) has been implicated in malignant progression across multiple cancer types, but its prognostic significance and association with tumor immune microenvironment features in gastric cancer (GC) remain incompletely understood. In this study, we in...

Neutrophil percentage-to-albumin ratio is associated with in-hospital mortality in patients with acute aortic dissection: a multicenter retrospective cohort study

Early risk stratification remains challenging in patients with acute aortic dissection (AAD). This study aims to evaluate the prognostic value of neutrophil percentage-to-albumin ratio (NPAR) for in-hospital mortality in patients with acute aortic dissection. We performed a multi...

Intersectional fairness in vision-language models for medical image disease classification

Medical artificial intelligence (AI) systems, particularly multimodal vision-language models (VLM), often exhibit intersectional biases, with models systematically less confident in diagnosing marginalised patient subgroups and producing higher rates of missed diagnoses. Current...

Self-care recovery after ischemic stroke: a quasi-experimental comparison of two psychological interventions

Post-stroke patients often experience cognitive, psychological, and self-care impairments. Comparative evidence on mindfulness-based interventions and cognitive rehabilitation interventions remains limited. This study compared two psychological interventions (Mindfulness-Based St...

Ki-67/p53-associated angiogenic heterogeneity for preoperative WHO grading of meningiomas: a spatial habitat radiomics study

This study aimed to develop and validate a classification model for preoperative prediction of WHO grading of meningioma based on spatial habitat radiomics that can be explained by Ki-67 and p53 biomarkers. A retrospective cohort of 400 patients (261 WHO grade I; 139 grade II/III...

Enhanced salivary correlation between Streptococcus mutans and herpes simplex virus-1 in oral squamous cell carcinoma: a case-control study

Streptococcus mutans modulates local immune responses in the oral mucosa and has been implicated in oral squamous cell carcinoma (OSCC) pathogenesis. Emerging evidence suggests that certain oral bacteria can influence viral infections through immune modulation. This case-control...

Untargeted 1H-NMR metabolomics of bronchoalveolar lavage fluids to identify biomarkers for early diagnosis of lower respiratory tract infections

Lower respiratory tract infections (LRTIs) remain a leading cause of death worldwide. Their complex clinical presentation underscores the need for accurate, timely laboratory diagnosis; however, reliable diagnostic biomarkers are still lacking. We performed untargeted 1 H-NMR met...

Experimental modal-based damage evaluation of masonry cross-vaults under quasi-static and dynamic cyclic loading

Masonry cross-vaults are double-curvature structural systems widely employed in historic churches and monumental buildings, which exhibit a pronounced vulnerability to seismic actions owing to the mechanical characteristics of their constituent materials. In such structures, diag...

Disturbance-observer-based adaptive neuro-fuzzy sliding mode control for collaborative ASV and URV systems

This paper proposes a disturbance-observer-based adaptive neuro-fuzzy sliding mode control (DO-ANFSMC) framework for collaborative autonomous surface vehicle (ASV) and underwater robotic vehicle (URV) systems operating in search-and-rescue missions under environmental disturbance...

Pain characteristics and risk of scale-identified cognitive impairment among middle-aged and older Chinese adults: a longitudinal study from CHARLS

Cognitive impairment and chronic pain have become major public health challenges, adversely affecting the lives of middle-aged and older adults. However, longitudinal evidence on pain characteristics and subsequent cognitive outcomes in Chinese populations remains limited. We exa...

10.6 μm laser moxibustion can improve oxidative stress and abnormal energy metabolism in liver of hypothyroidism rats through Nrf2/HO-1 and Nrf2/PGC-1α/TFAM pathways

Hypothyroidism (HypoT) is a systemic hypometabolic disorder characterized by thyroid hormone deficiency and is closely associated with oxidative stress (OS). The hypothalamic-pituitary-thyroid (HPT) axis plays a key role in regulating thyroid hormone secretion and the Nrf2 signal...

Data-driven identification of modifiable risk factors for colorectal cancer in Palestine using machine learning methods

Colorectal cancer (CRC) is a growing public health concern in Palestine, yet limited evidence is available on locally relevant behavioral, dietary, socioeconomic, and contextual predictors. Machine learning (ML) may support prevention-oriented risk stratification by identifying c...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...

Quality of postoperative recovery in patients undergoing laparoscopic colorectal cancer resection as affected by transversus abdominis plane block combined with moderate neuromuscular blockade: a randomized controlled trial

Postoperative recovery quality in laparoscopic surgery may benefit from deep neuromuscular blockade, whereas the effects of combining transversus abdominis plane block (TAPB) with moderate neuromuscular blockade in this regard remain unreported. This work investigated whether mod...

Emerging Trends in the Incidence (1999–2022) and Mortality (1999–2023) of Thyroid Cancer in the United States: CDC WONDER Database Study

Background: Thyroid cancer (TC) is a common endocrine malignancy with a rising global incidence. This study examined trends in TC incidence and mortality in the United States over the past two decades. Methods: TC mortality data from 1999-2023 and incidence data from 1999-2022 we...

Optimization-driven feature learning for long-tailed object detection in optical remote sensing imagery

With the rapid advancement of remote sensing technologies, deep learning–based object detection has been widely adopted for large-scale optical remote sensing imagery. Despite the remarkable progress achieved by convolutional and transformer-based detectors, their performance rem...

Application of multi-technique integration in the prenatal diagnosis of mosaicism derived from an ICSI blastocyst: a diagnostic approach and clinical implications

To investigate the prenatal diagnosis following intracytoplasmic sperm injection (ICSI) and blastocyst transfer. By integrating multiple cytogenetic and molecular techniques, we characterized a mosaic duplication of chromosome 20p, evaluated its pathogenicity and clinical signifi...

Cancer drug response and resistance: molecular mechanisms and combating strategies

Despite remarkable advances in cancer drug treatment, including chemotherapy, targeted therapy, and immunotherapy, therapeutic resistance remains a formidable clinical barrier, limiting durable responses and long-term survival. Drug resistance can be broadly categorized as intrin...