Research works

Heterogeneity of Response to Early Start Denver Model: Identifying Developmental Trajectories and Predictors of Cognitive Outcomes

Autism is a highly heterogenous neurodevelopmental condition that can significantly compromise the quality of life. For children showing atypical trajectories of development in their early years, early and intensive intervention has shown promise in enhancing the development of l...

The underutilized role of immigrant-serving community organizations in addressing environmental injustice: a qualitative study in Utah

Utah’s Wasatch Front is a growing metropolitan area facing looming environmental challenges, including poor air quality that is exacerbated by the rapid desiccation of Great Salt Lake. Immigrant populations are disproportionately exposed to air pollution in the region, a result o...

GBA1 mutations as a role model for precision medicine in Parkinson’s disease

Abstract Genetic variants in GBA1 , encoding the lysosomal enzyme glucocerebrosidase (GCase), represent the strongest genetic risk factor for Parkinson’s disease (PD) and provide a mechanistic link between Gaucher disease (GD) and PD. While biallelic GBA1 mutations cause GD, hete...

Wolbachia infection and its relationship with mtDNA diversity in Hesperiinae (Lepidoptera: Hesperiidae)

Abstract Wolbachia, a widespread facultative endosymbiont in arthropods, not only manipulates host reproduction but also influences the genetic diversity of mitochondrial DNA through maternal inheritance. Despite being extensively reported across various insect taxa, Wolbachia in...

E8 Non-Local Entanglement via Phi-Scaled Vertex-Rotation Symmetry — E8 Intelligence Research

The 240-root lattice structure dictates that any torsional displacement at a 132Hz injection node induces instantaneous phase-alignment across non-adjacent Coxeter planes via phi-scaled rotation. This establishes a non-local geometric bridge where information is encoded not in th...

E8 singleton void states optimize black hole entropy reduction — E8 Intelligence Research

The E8 Lie group's unique 240-dimensional root system enables a novel discretization of spacetime singularities through 120 paired void states. These "voidcoins" represent negative entropy reservoirs that offset black hole information paradox losses via φ-linked lattice surgery....

Multi-Axle Reference and Temporal-Consistency Deep SVDD for EMU Traction Motor Bearing Anomaly Detection Using Field Vibration Data

Field vibration monitoring of EMU traction motor bearings is commonly constrained by weak or relative labels, fluctuations in operating conditions, and limited abnormal samples. Under these conditions, learning a normal boundary from a single bearing position may be unstable, and...

Enhanced Pigeon-Inspired Optimization-Based Active Disturbance Rejection Control for Carrier-Based Aircraft Landing Direct Lift Control

Carrier-based aircraft landing is a critical element in generating aircraft carrier combat capability. Traditional landing control suffers from inherent drawbacks including strong trajectory–attitude coupling, high pilot workload, and insufficient disturbance rejection in complex...

Focused ultrasound-mediated opening of the blood brain barrier for non-invasive drug delivery to the murine cerebellum

Abstract Background The blood brain barrier (BBB) limits effective treatment for cerebellar diseases. Region-specific parameterization and safety data for MRI-guided focused ultrasound (MRgFUS) BBB opening (BBBO) in the cerebellum are scarce. The goal of this study is to establis...

Bioactive phytochemicals and health-promoting effects of green onion (Allium fistulosum L.): a scoping review

Abstract As interest in health functional foods increases, research on plant-derived bioactive raw materials has expanded. Among Allium species, Allium fistulosum L. (green onion) remains relatively underexplored compared with Allium sativum L. (garlic), despite its historical pr...

ESG Uncertainty and Corporate Waste Management: Global Evidence

ABSTRACT Motivated by the growing concerns over environmental sustainability and the increasing relevance of environmental, social, and governance (ESG) metrics in corporate decision‐making, this study examines the impact of ESG‐related uncertainty on corporate waste management....

Intermediate rectal dose is associated with late toxicity after prostate SBRT: a dose–volume histogram principal component analysis

PURPOSE: To evaluate whether principal component analysis (PCA) of rectal and bladder dose-volume histograms (DVHs) identifies dose regions associated with late toxicity after prostate stereotactic body radiotherapy (SBRT). METHODS/PATIENTS: This retrospective single-institution...

Impact of an unrestricted clear liquid fasting protocol on pediatric perioperative outcomes: a prospective interventional study

PURPOSE: Traditional preoperative fasting guidance (6-4-2) aims to reduce aspiration risk but frequently produces prolonged fasting and discomfort in children. We evaluated whether progressively liberalizing the clear-liquid fasting policy reduces fasting time and improves the pe...

Childhood‐Onset Movement Disorders at the Forefront: From Genes to Precision Therapy

Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Disclosure Form Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other...

A healthy lifestyle as a value-based and target-oriented vector of education

This article explores a new methodological approach to studying the development of healthy lifestyle values in the younger generation. It analyzes studies devoted to this issue and reveals the potential of a healthy culture. Data from a student survey is presented, demonstrating...

Engineering and land use intensified climate-driven Yangtze River flood hazards since the Little Ice Age

Understanding the interplay between climate variability and human activities is essential for assessing long-term river flood hazards. Yet, the relative contributions of natural and anthropogenic drivers to flood magnitude remain poorly constrained due to limited multicentury rec...

Probabilistic Graphical Modeling for Machine Tool Dynamics with a Case Study in 3D Printer Vibration Compensation

Abstract This paper presents a new framework for modeling machine tool dynamics, aiming to enable their integration in machine tool digital twins. The framework is formulated as a Dynamic Bayesian Network, in which model parameters, sensor and process observations, and decision v...

“Oh my gosh, you’re too young to be sick!”: Unpacking the consequences of workplace mistreatment for young adults with disabilities.

Despite comprising a significant percentage of the workforce and being susceptible to mistreatment, young adults with disabilities have not been widely focused on in the workplace mistreatment literature. In this study, we take an intersectional approach as we examine the specifi...

Weakly-Supervised Detection and Quantification of Vitreous Opacities in OCT Images Using Synthetic Data Augmentation

Vitreous opacities — colloquially known as eye floaters — represent a clinically underserved visual condition affecting an estimated 25% of the global population. Despite causing significant impairment in quality of life, no standardized objective measurement tool exists in clini...

A Cause-Oriented Cyber Threat Taxonomy: The Top Level Cyber Threat Clusters Framework

Cybersecurity discourse routinely uses the term "cyber threat" to denote several distinct concepts at once: the cause of a compromise, its outcome, the actor responsible, and the technique employed. This conflation impedes consistent classification, comparable incident documentat...