Research works

Sulfated PSGL-1 primes the enterovirus A71 fivefold vertex for localized remodeling

Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease and poses a significant public health threat through severe neurological complications in pediatric cases. P-selectin glycoprotein ligand-1 (PSGL-1) functions as an attachment factor, yet the structural basis of PSGL-1...

Adherence to medications, lifestyle advice, and self-monitoring for type 2 diabetes and hypertension in sub-Saharan Africa: A systematic review, meta-analysis, and interactive network analysis

Background Type 2 diabetes and hypertension are major public health challenges in sub-Saharan Africa, yet treatment control remains poor. Patient adherence to key treatment pillars (medication, lifestyle advice, and self-monitoring) is essential for treatment control, yet adheren...

Early-mid Holocene Ross Sea extreme wave heights reflect sea ice retreat and ocean-atmosphere interactions

Abstract Antarctic coastal systems preserve valuable records of postglacial environmental change and extreme storm events. On Inexpressible Island, Ross Sea, we integrated geomorphic mapping, boulder measurements, exposure dating, radiocarbon constraints, and hydrodynamic analysi...

Magnetotactic bacterial-reprogrammed TCR-macrophages for durable anti-tumor photoimmune therapy

Macrophage have shown great promise in the clinical treatment for head and neck cancer (HNC). However, macrophage therapies confront significant hurdles due to a deficiency of tumor-specific targets and tumor resistance. Herein, we report the development of a magnetotactic bacter...

Morphological and Metabolic Changes During Callus-Based Shoot Regeneration in Chamaecyparis obtusa

Chamaecyparis obtusa is a valuable conifer species, prized for its high-quality timber and bioactive essential oils. However, commercial micropropagation is challenging due to its resistance to vegetative propagation. This study aimed to develop an efficient in vitro plant regene...

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

The COVID-19 pandemic and its protracted consequences underscore the urgent need for more effective antiviral strategies. Current antiviral strategies face a persistent challenge achieving sufficient viral suppression while minimizing off-target toxicity, particularly against suc...

Al-Saaidi data and materials

This repository contains the datasets and supporting materials associated with the manuscript entitled "Nano-Encapsulated Curcumin Improves Ovarian and Uterine Recovery from Cadmium Toxicity in Rats."

Micro-CT Assessment of Dentin Mineral Density and Furcation Morphology in Primary First and Second Molars

Background/Objectives: The furcation region of primary molars is a critical anatomical zone with high clinical relevance in endodontics and restorative dentistry due to its proximity to the pulp chamber and potential accessory canal communications. This study aimed to quantitativ...

Amortized Structural Inference for Media Mix Models: A Gated Architecture for Calibrated, Zero-Configuration Measurement

Media mix models (MMMs) require substantial expert configuration: adstock priors, saturation parameterizations, pooling strengths, and model-family choices are set by practitioners, and these choices materially affect the budget decisions the models inform. We ask whether that co...

Volatility Shocks in Stock Futures during Election Period in India

Abstract In India, the elections usually influence limited volatility in the stock market and as they are of recurring nature, the results can be of use to investors in similar circumstances in future. Therefore, this paper aims to examine volatility in Indian Equity futures duri...

Parametric Study of Yields and Properties of Corn Stover-Derived Hydrothermal Liquefaction Products by Using Statistical Approaches

Hydrothermal liquefaction (HTL) of lignocellulosic biomass produces multiple product fractions, including solid residue (SR), heavy bio-oil (HBO), aqueous phase (AP), and light bio-oil (LBO). This study mainly applied principal component analysis (PCA) and regression modeling to...

Genome-wide identification of the chalcone synthase (CHS) family in tigernut and function analysis of cechs57 in drought stress response

Drought stress is a major abiotic constraint that severely impairs crop growth and reduces yield globally. Identification of drought-tolerant candidate genes and their application in molecular breeding represent effective strategies to alleviate drought-induced losses. Genome-wid...

Dedifferentiated Chondrosarcoma of the Distal Femur: Diagnostic Challenges and Limb Salvage with Double-Barrel Fibular Graft Reconstruction

Dedifferentiated chondrosarcoma (DCS) is a rare and aggressive variant of chondrosarcoma characterized by a biphasic histological pattern and poor prognosis. We report a case of DCS arising in the distal femur of a 48-year-old woman who presented with progressive pain and swellin...

Multi-Objective Optimization of Nozzle Closing Strategies for High Head Pelton Turbines to Shorten the Nozzle Closing Time and Mitigate Water Hammer Effects

The rapid shutdown of high-head and large-capacity Pelton turbines equipped with long penstocks often induces severe water hammer effects, threatening the structural safety of the diversion system. Traditional linear or simple piecewise nozzle closing laws struggle to achieve an...

Affective Organizational Commitment Links Job Satisfaction to Quiet Quitting in Healthcare Workers: The Amplifying Role of Career Engagement

Background/Objectives: This study examined the relationships among job satisfaction, affective organizational commitment, career engagement, and quiet quitting in healthcare workers. Specifically, we tested a moderated mediation model in which affective organizational commitment...

Can Carica papaya Serve as an Adjunct to Semaglutide in Mitigating Diabetes-Induced Testicular Injury Through Modulation of Oxidative Stress, Inflammation, Apoptosis, and the miR-34c/miR-155–SIRT1/FOXO1 Axis? An Experimental and Chem-Bio-Informatics Study

Diabetes mellitus (DM) induces significant endocrine disruption and oxidative stress (OS) within the testes, resulting in impaired spermatogenesis, increased sperm abnormalities, and compromised reproductive function. This study aimed to evaluate the combined protective effects o...

Individualized statin associated type 2 diabetes risk estimation with a deep causal model

Statin therapy reduces cardiovascular risk, but recorded statin exposure is associated with subsequent type 2 diabetes (T2D) in some populations. Individualized risk estimation and separation of low-density lipoprotein cholesterol (LDL-C)-mediated from non-LDL components remain c...

Derivation of a Bioavailability-Based Environmental Quality Standard for Copper in European Freshwaters under the Water Framework Directive using an updated methodology

Copper (Cu) is a river basin specific pollutant under the European Water Framework Directive (WFD). Compliance assessment under the WFD should be based on a tiered approach that considers a bioavailability correction integrating local physico-chemistry conditions. The existing pr...

Pre‐Eclampsia and Maternal Cardiovascular Function: Insights Into Pathophysiology and Care (Scientific Impact Paper No. 79)

Plain Language Summary Pre‐eclampsia is a pregnancy complication that involves the development of high blood pressure in a pregnant woman and other features such as protein in the woman's urine, kidney or liver problems, or poorer growth for the baby. It can also have long‐term h...

Corrosion life evaluation of organic/zinc composite coatings in water-saturated acid soil using electrochemical impedance spectroscopy

The corrosion behaviour and service life of organic/zinc composite coatings in water-saturated acid soil were investigated using electrochemical impedance spectroscopy (EIS) and open-circuit potential (OCP) measurements. For the duplex system, the service life of the organic topc...