Research works

Associations of IL-2, IL-6 and IL-10 Gene Polymorphisms with Biochemical Parameters and Calcineurin Inhibitor Dosing in Kidney Transplant Recipients

Background/Objectives: Kidney graft dysfunction remains a major challenge limiting long-term transplant survival despite advances in immunosuppressive therapy. Cytokine signaling pathways have been implicated in the regulation of alloimmune responses and chronic inflammation, but...

Ultra-Short Hollow-Core Anti-Resonant Fiber Polarization Filter Covering C+L Band Based on SPR Effect

This paper proposes an ultra-short hollow-core anti-resonant fiber (HC-ARF) polarization filter covering the C+L communication band based on the surface plasmon resonance (SPR) effect. The structure consists of six composite tubes, each formed by nesting an elliptical cladding tu...

Hydrodynamic characteristics of an ILCA6 sailing dinghy in calm water and head waves

Abstract The ILCA6 (formerly Laser Radial) sailing dinghy frequently encounters wave conditions during training and competition, where wave-induced resistance and ship motions can significantly influence sailing performance. However, systematic investigations of the hydrodynamic...

Advancing durable and sustainable asphalt binder: Hybrid modification using recycled polypropylene and crumb rubber

This paper introduces a comprehensive framework for hybrid crumb rubber-recycled polypropylene binders, investigating the effects of formulation, mixing techniques, and ageing paths using rheological characterisation. Two shear-mixing protocols were used to create hybrid binders...

Late recurrence after radical nephrectomy for renal cell carcinoma in a patient with horseshoe kidney: a case report

Introduction: Horseshoe kidney (HSK) is the most common renal fusion malformation. Renal cell carcinoma (RCC) is the most prevalent malignancy reported in this anomaly. Case presentation: We present the case of a 61-year-old man with multiple recurrences of RCC in the context of...

RKMS / COR External Handoff Package — Release Candidate 0.1.1

RKMS / COR RC 0.1.1 is a recoverable technical handoff of a typed relational architecture, executable semantic checker (COR-IR), relational-search/candidate-generation bridge, relational navigation loop, provenance machinery, frozen tests, preserved failures, reproduction scripts...

Intersectionality and Its Influence on PrEP Uptake and Adherence Among MSM: A Scoping Review

Oral pre-exposure prophylaxis (PrEP) is an effective human immunodeficiency virus (HIV) biomedical intervention. However, men who have sex with men (MSM) continue to experience disproportionately high HIV prevalence due to intersecting marginalised identities and systemic inequit...

Dynamic Uncertainty Learning with Noisy Correspondence for Text-based Person Retrieval

Text-Based Person Retrieval (TBPR) aims to locate a person in an image database based on a natural language description. While effective in theory, TBPR faces substantial challenges in real-world scenarios due to noisy correspondences —misaligned or weakly related image-text pair...

Genetic Architecture of Synaptic Failure in Dementia with Lewy Bodies: From α-Synuclein Proteoforms to GBA1-Mediated Plasticity Deficits

Dementia with Lewy bodies (DLB) is increasingly conceptualised not merely as a disorder of neuronal death but as a primary synaptopathy in which the functional collapse of synaptic transmission and plasticity precedes, and predicts, neurodegeneration and clinical decline. Two gen...

Agentic AI for Data Engineering: A Systematic Review of Autonomous Pipeline Construction, Optimization, and Governance

Data engineering is increasingly cited as a proving ground for agentic AI, with surveys reporting daily AI tooluse among 82% of data professionals — yet most of that use remains tactical rather than autonomous, and only a small fraction of teams describe their data modeling pract...

Vaccinations during pregnancy in Germany between 2004 and 2022: a claims data analysis

Abstract Data on vaccinations during pregnancy are lacking in Germany. We aimed to assess the proportion of pregnancies with any vaccination over a 19-year period. Using health claims covering approximately 20% of the German population, we included pregnancies beginning between 2...

Pythagorean-Platonic Number Mysticism: Geometric Harmonies and Cosmic Constants — E8 Intelligence Research

**FINDING:** Pythagorean-Platonic tradition identifies number as the fundamental substance of reality, with geometric forms encoding harmonic ratios and cosmic cycles. **MATH:** Key constants: φ (1.618...), √2 (1.414...), √3 (1.732...), π (3.141...), and the tetractys (1+2+3+4=10...

Actualization of Jomon Velocity

Definition Definition 1. If an object gets momentum or loses momentum, the manifested velocity of the object is actualized.

Harnessing Diversity: Majority‐Group Acculturation Predicts Creativity and Flourishing Over Time

ABSTRACT Creativity and flourishing are core aims of higher education (HE) institutions and government initiatives globally. Large‐scale projects have linked creativity and flourishing with cultural diversity, yet their associations with majority‐group acculturation (i.e., how me...

Plimpton 322: World's Oldest Trig Table Using Base-60 Ratios — E8 Intelligence Research

FINDING: Babylonian tablet Plimpton 322 is the world's oldest known trigonometric table, using base-60 (sexagesimal) ratios rather than angles or circles. | MATH: The tablet lists 15 rows of Pythagorean triples (a² + b² = c²) in sexagesimal notation, with ratios b²/(c² – b²) form...

Pleural Empyema Caused by Streptococcus Constellatus in an Immunocompetent Young Adult: A Case Report

Objective: Members of the Streptococcus anginosus group (SAG) are associated with deep-seated and purulent infections. Pleural empyema caused by Streptococcus constellatus is rare and is more commonly reported in immunocompromised individuals. This report describes a case of S. c...

KM Algebraic Geometry: Algebraic Screening, Representation Defects, Homological Methods, and Derived Reconstruction A Special Monograph in KM Theory

We develop KM algebraic geometry as a typed comparison theory for algebraic structures before and after screening. The objects under consideration include rings, modules, associative and graded algebras, representations, chain complexes, sheaves, schemes, algebraic cycles, deform...

Individualized Prediction of Recurrence Following Uterine-Preserving Pelvic Organ Prolapse Repair Using Internally Validated Machine Learning Models

Background/Objectives: Approximately 11–20% of women affected by pelvic organ prolapse (POP) will undergo surgical intervention during their lifetime and nearly one-third of these women will require an additional procedure due to recurrence or failure of the initial repair. This...

Novel Use of Penile Ultrasound in the Evaluation of Patients With Adult Acquired Buried Penis

Adult acquired buried penis (AABP) disease is a risk factor for penile cancer. For a subset of patients, the severity of their disease precludes complete physical examination of the penile shaft due to the inability to exhume the penis. Thus, providers are unable to identify peni...

Frequency and nature of complications of deep anterior lamellar keratoplasty

OBJECTIVE: The study analyzed intraoperative and postoperative complications of deep anterior lamellar keratoplasty (DALK) performed in 2008-2023 at the Krasnov Research Institute of Eye Diseases. MATERIAL AND METHODS: This retrospective study included 523 patients (548 eyes) wit...