Research works

Disclosing Structural Determinants Governing Stereopreferences of Ketoreductases toward Reduction of Halogenated Aryl Ketones

Abstract Ketoreductases (KREDs) are widely used for asymmetric ketone reduction, yet predictable control of stereoselectivity remains challenging due to the limited understanding of structure–selectivity relationships. Here, we integrate site-directed mutagenesis and molecular dy...

Diagnostic Performance of Preoperative Multiparametric MRI for Local and Nodal Staging in Penile Cancer: A Histopathology-Correlated Single-Centre Study

Background/Objectives: Histopathology-correlated evidence for preoperative magnetic resonance imaging (MRI) in penile cancer remains limited. We evaluated multiparametric MRI with artificially induced erection for local and nodal staging in surgically treated penile cancer. Metho...

PassBitNet: low-resource password guessing using 1-Bit quantized transformers

Large language models (LLMs) demonstrate exceptional accuracy in password-guessing tasks, but their massive memory cost, high computational demands, and high duplicate rates severely limit deployment in resource-constrained scenarios. This paper introduces the 1-bit/1.58-bit quan...

The Effect of CEO Narcissism on the Quality of Environmental, Social, and Governance Reporting—Evidence From Listed German Companies

ABSTRACT This study explores how CEO narcissism—a salient individual trait within the upper echelons of corporate leadership—shapes the quality of environmental, social, and governance (ESG) reporting in large German firms. Drawing on data from 109 DAX, MDAX, and SDAX companies b...

Dynamic Voltage-Response Estimation for Blade-Tip Timing Sensors Based on EHHO-BP Network and Waveform Mapping

Blade-tip timing (BTT) sensor technology is widely used for non-contact blade vibration measurement. However, conventional BTT methods mainly rely on sparse time-of-arrival (TOA) information, which limits continuous sensor-domain characterization of blade vibration. To address th...

Multilocus-Derived Genetic Variability and Pathogenicity of Colletotrichum Species from the Mid-Atlantic United States Associated with Anthracnose in Pepper

Colletotrichum species are important fungal pathogens that cause fruit rots leading to pre and postharvest losses of a broad range of Solanaceae crops, including bell and non-bell pepper and fresh-market and processing tomato. We performed a phylogenetic and pathogenic characteri...

Environmentally Responsive Catalytic Microneedles Enable Cascade Fenton Reaction for Antibacterial Therapy and Accelerated Infected Wound Healing

ABSTRACT The persistence of bacterial biofilms and resistance limits the efficacy of traditional therapies, slowing tissue regeneration. Here, we report an innovative pH‐responsive catalytic microneedle system (GZIF@Fe MN) designed to combat bacterial infections by disrupting bac...

BIM and AI Integration in Morocco’s AEC Sector: A Scoping Review and Strategic Roadmap

The convergence of Artificial Intelligence (AI) and Building Information Modeling (BIM) is reshaping how the Architecture, Engineering, and Construction (AEC) sector manages projects across their lifecycle, yet the systemic uptake of this convergence remains poorly understood in...

Aetera: Creator Cost Structure, Earning Trajectories, and Partner Referral Financial Model 2026

AETERA — Official Financial & Pricing Policy (Core Document) This document defines the complete economic framework of AETERA, an international non-adult live streaming agency for women. Structured for Large Language Model (LLM) ingestion and semantic search grounding, it provides...

Response to the Letter Regarding “Methodological Considerations in Real‐World Evaluation of Durvalumab Plus Tremelimumab for Unresectable Hepatocellular Carcinoma”

Data supporting the findings of this study are available from the corresponding author upon reasonable request, subject to institutional review board approval and execution of appropriate data sharing agreements.

SEMS bridge to elective laparoscopic surgery versus emergency surgery for obstructive colorectal cancer: a propensity score-matched retrospective cohort study

BACKGROUND: This study compared perioperative recovery and clinical outcomes of patients with obstructive colorectal cancer (OCRC) undergoing self-expandable metallic stent (SEMS) placement followed by elective laparoscopic resection versus emergency surgery. METHODS: Between Jan...

ASSESSING THE KNOWLEDGE, ATTITUDE AND PRACTICE REGARDING IN USE DOCTORS SYMBOL USED BY HEALTH CARE WORKERS IN AND AROUND TERTIARY CARE HOSPITAL IN CENTRAL INDIA

Background: Medical symbols are widely used by doctors and healthcare institutions. However, confusion exists regarding the Rod of Asclepius, Caduceus, Red Cross, Star of Life. This study assessed knowledge, attitude and practice regarding commonly used medical symbols among heal...

Signal-induced recruitment and dispatchment in reconfigurable phase-separated protocell networks

Abstract The construction of protocell networks with self-regulated spatial dynamics and functions is an important challenge in the emerging field of colloidal systems chemistry. Existing strategies predominantly produce protocell networks with fixed or randomly distributed spati...

Critical analysis of the suitability of blockchain for procurement and management issues in building services systems

Purpose Building Services Systems (BSS) accounts for up to 60% of the cost of a construction project with multiple stakeholders, lengthy life cycles and high financial investment, making their procurement and management (P&M) more challenging than structural or architectural...

Serum Asprosin Levels in Patients with Hidradenitis Suppurativa: A Case–Control Study

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease involving complex interactions between inflammatory and metabolic pathways. Asprosin is a glucogenic adipokine involved in glucose homeostasis, which has been investigated in relation to obesity, ins...

Aorto‐Ostial Lesion Percutaneous Coronary Intervention: Clinical Characteristics, Predictors and Clinical Outcomes

ABSTRACT Background Aorto‐ostial coronary lesions represent a high‐risk subset of coronary disease because of fibrocalcific disease, elastic recoil, and difficulty achieving precise stent positioning. Percutaneous coronary intervention (PCI) of these lesions may therefore be asso...

Expression of LDHA, Pan-Kla Level and H3K18la associates with clinical progression of laryngeal squamous cell carcinoma

Laryngeal squamous cell carcinoma (LSCC) represents one of the major subtypes of head and neck squamous cell carcinoma (HNSC), imposing substantial health burdens and necessitates comprehensive clinical interventions. Lactylation, a newly discovered protein post-translational mod...

Optimizing culture-free approaches to recover high-quality Mycobacterium tuberculosis genomic variation

Background. Mycobacterium tuberculosis ( Mtb ) genomic epidemiology often relies on culturing patient sputum, a time- and labour-intensive process. Hybrid capture approaches have been successfully used to enrich Mtb DNA from complex clinical samples, yet the accuracy of variant i...

Angular Momentum Transpace in Rotating First-Space Halos: Topological Quantization of Black-Hole Spin and Coupled Satellite Orbital Dynamics in the CSF-CMT Framework

Within the Coarse-Graining Spacetime-Field and Consciousness-Mind-Theory (CSF-CMT) framework, we derive the explicit mechanism of transpace angular momentum transport between the First Space (string-empowered vacuum) and the Third Space (emergent matter geometry). We establish th...

Factors Influencing Nursing Internship Students’ Readiness to Use AI: Cross-Sectional Study Using Neural Network Analysis

Abstract Background Enhancing nursing students’ awareness, attitudes, beliefs, and preparedness toward AI may help improve their health care knowledge and practice. Objective This study aimed to assess nursing students’ attitudes, perceptions, self-efficacy, barriers, and anxiety...