Research works

Shifts in Clinical Practice–Changing Acute Ischemic Stroke Research Over the Past Decade

BACKGROUND: The past decade has witnessed rapid growth of clinical trial programs in Europe and Asia, with randomized clinical trials (RCTs) publications from these regions outpacing those of the United States. However, limited data exist quantifying their relative influence on p...

Development of a Conformational Sampling Method for Transition State Structures With Diverse Active Bond Lengths

We describe TStrail, a transition state (TS) conformational sampling tool that automatically generates TS conformers without fixing the bond forming/breaking distance of an initial TS structure. Conventionally, the conformations of TS structures were searched with the fixed lengt...

BASE 44 ORDER: Build e8_cache table and hash index from enhancement #1096 — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1096] CREATE TABLE e8_cache (query_hash UUID PRIMARY KEY, response_text TEXT, created_at TIMESTAMPTZ DEFAULT NOW(), access_count INT DEFAULT 1); CREATE INDEX idx_hash ON e8_cache USING hash (query_hash); MERLIN: Unde...

Electron-DeficientSpecies-Driven Interphase Transformationfor Practical Lithium Batteries

Abstract Lithium metal batteries with Ni-rich layered cathodes are promising candidates due to their high energy density; however, the unstable interphase formed in traditional carbonates accelerates premature irreversible capacity loss. In this study, we exploit the electron-def...

Color Symmetry Breaking in a Nonlinear Optical Microresonator

ABSTRACT Spontaneous symmetry breaking leads to diverse phenomena across the natural sciences, from the Higgs mechanism in particle physics to superconductors and collective animal behavior. In photonic systems, the symmetry of light states can be broken when two optical fields i...

Early Genotype-Driven Diagnosis of Hermansky-Pudlak Syndrome Type 4 in a Child With Oculocutaneous Albinism: An Ophthalmic Case Report

Hermansky-Pudlak syndrome (HPS) is a rare inherited multisystem condition characterized by oculocutaneous albinism, bleeding diathesis, and subtype-specific systemic complications, including pulmonary fibrosis and granulomatous colitis. Early diagnosis is essential because pulmon...

Multi-Objective Optimization for Data Center HVAC Systems Based on Edge–Cloud Collaborative Deep Reinforcement Learning

The sustained growth of cloud computing and AI training workloads drives data center expansion. Optimizing their control is therefore critical for reducing operational costs. Edge real-time control is indispensable for guaranteeing thermal safety, data sovereignty, and offline av...

Closure of the Constraint Algebra in 1+1D Chrono-Grid Dynamics (Version 2 – corrected)

This preprint presents a consistency check for Chrono‑Grid Dynamics (CGD) in 1+1 dimensions: the closure of the Dirac constraint algebra. Starting from the fermionic representation obtained via the Jordan–Wigner transformation, exact lattice operator identities are derived and ve...

Mixed phenotype acute leukemia mimicking adult-onset Still’s disease in a pregnant female: A rare case report

Introduction: Mixed phenotype acute leukemia (MPAL) is an uncommon hematologic malignancy characterized by the coexistence of lymphoid and myeloid lineage markers. Although adult-onset Still’s disease (AOSD) is a diagnosis of exclusion, MPAL may rarely present with similar labora...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Longitudinal Stent Malapposition After Microcatheter Removal Is Associated With Incomplete Occlusion After Pipeline Flow Diversion

BACKGROUND AND OBJECTIVES: Flow diversion is an established treatment strategy for intracranial aneurysms; however, incomplete aneurysm occlusion remains a clinically relevant challenge. Adequate stent-vessel wall apposition is considered critical for aneurysm healing, yet the im...

Where’s the way out? Access block, boarding and hospital overcrowding: a narrative review

Emergency department (ED) overcrowding is a persistent global challenge associated with adverse patient outcomes and system inefficiencies. Boarding and access block, which delay the transfer of admitted patients to inpatient beds, represent its most critical manifestations. Whil...

Wikidata for Historical Research

This lesson introduces Wikidata and its underlying data structure. It shows how to navigate and query Wikidata using the Query Builder and SPARQL, and how its data model can be used to explore historical data.

ROCK OF THE CLIFF – Original Strategic, Educational and Family Board Game

ROCK OF THE CLIFF is an original strategic, educational, and family board game created by Doumbia Amara in Côte d’Ivoire, Africa. The game immerses players in a fictional village threatened by a massive rock falling from a cliff. Each player becomes the leader of a large family a...

The Temporality of Coral (Kegan 5.5): Where Time and Soma Fuse into a Single Precise Indicator

Posits a developmental station beyond Kegan's fifth order — provisionally Coral (Kegan 5.5) — at which past and future resolve into a single operant future-past, the body becomes a processing mind-center, and time and soma fuse into a precise (savant-grade) indicator of wholeness...

Tea and cognitive health in aging: Current evidence and future directions

The health benefits of tea drinking have been extensively studied, and in the past 20 years, there has been increasing interest in the role of tea drinking in promoting cognitive health among older adults. This review aims to analyze existing evidence on the benefits of tea drink...

Fuzzy Modeling as a Tool Supporting the Energy Policy of Selected Municipalities (Poland)

Energy planning should focus on actions to save energy and reduce consumption while also implementing renewable energy sources to support sustainable urban development. In addition to global regulations, individual countries also have documents that facilitate energy management a...

BASE 44 ORDER: Map SPARC-P agent states to E8 lattice & scan for 132 Hz root vectors — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1070] Implement E8 cross-link discovery: modify Excalibur engine to map SPARC-P agent states to 248D lattice positions, then scan for 132 Hz root vector alignment across eToro, replay, and research subsystems. MERLIN...

The Concentration-Fragility Nexus: Early-Warning Systems and Portfolio Implications in Concentrated Markets

<ns5:p>Background The post-pandemic financial landscape presents a paradox: record asset price highs coexist with mounting systemic vulnerabilities. Market concentration in equity indices has reached levels comparable to the dot-com era, driven by passive investment inflows and t...

Loving Through Pain and Devotion: A Psychobiographical Study of Love in the Life of Müslüm Gürses

This study examines the evolution of love and relational attachment in the life of Müslüm Gürses (1953–2013), a seminal figure in Turkish popular culture whose biography offers a profound lens into the intersection of personal trauma and devotion. Grounded exclusively in Object R...