Research works

Stable truncating mutations in plakophilin-2 induce arrhythmogenic cardiomyopathy-like phenotypes in adult zebrafish

Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac disorder characterized by arrhythmias and fibrofatty myocardial remodeling, often leading to heart failure and sudden cardiac death. Mutations in plakophilin-2 ( PKP2 ) represent the most prevalent genetic cause of ACM....

Co-pyrolysis of pine cones and natural resin: Tailoring microporous architecture and interfacial alkalinity for enhanced heavy metal immobilization

This study presents a novel approach for the highly efficient separation of Cu 2+ and Pb 2+ from aqueous phases using advanced activated carbons synthesized via the co-pyrolysis of pine cones and natural resin, followed using CO 2 physical activation. The strategic incorporation...

Operational Effects of Power-to-Electric Boiler Considering Flexible Operation of Nuclear Power Plants

This study evaluates the operational effects of power-to-electric boilers (P2eB) in the 2030 Korean power system, considering flexible nuclear operation. A reserve-constrained unit commitment model jointly optimizes the power and heat systems while representing nuclear output red...

Uncertainties in adaptation pathways planning: Insights from diverse international case studies

Adaptation Pathways are receiving increased attention as a method to navigate future climate risks under conditions of deep uncertainty. Despite their promise to uncertainty management, questions remain about how uncertainty is conceptualized and addressed in practice. While prev...

The next generation of maternal vaccines: scientific advances, regulatory readiness, and strategic planning in Europe

With the recent approval of maternal RSV vaccines and late-phase trials underway for a GBS vaccine, Europe is entering a new era of maternal immunisation. Yet scientific progress is outpacing pregnancy-specific evidence and preparedness for equitable implementation. Pregnant wome...

Compression behaviour of stiffened double skin tubular columns: Influence of stiffener number and sub-panel width

Double-skin tubular columns (DSTCs) represent one of the most advanced lightweight steel-concrete composite designs featuring two concentrically arranged hollow steel tubes, with concrete infill positioned between them. These light weight DSTCs are very efficient at withstanding...

Parametric Estimation of Tanker Deckhouse Volume from Direct General Arrangement Measurements

This study analyses the parametric scaling of deckhouse volume ( Vdh) and engine casing volume ( Vec) of oil tankers, based on direct measurements of general arrangement (GA) drawings of 80 vessels from Handysize to VLCC in RINA Significant Ships (1991–2019). Power-law regression...

Osteoporosis treatment via programmed delivery of IRF5 siRNA to macrophages in bone tissue combined with ROS scavenging

Postmenopausal osteoporosis (PO) is not merely a consequence of increased osteoclast activity. Estrogen deficiency induces oxidative stress and pro-inflammatory M1 macrophage polarization in bone tissue, thereby sustaining osteoclastogenic stimuli and pathological bone resorption...

Numerical and experimental investigation of laser remelting in selective laser melting of 316L stainless steel

Selective laser melting (SLM) has a wide application potential as a near-net-shape manufacturing process, but with the increasing quality requirements of additive manufactured parts in various industries, high demands are placed on the manufacturing quality, density uniformity an...

Persistence and fragmentation of Dry Thorn and Than-Dahat Forests in the Central Myanmar Dry Zone over the last 25 years

The Central Myanmar Dry Zone (CDZ) contains some of Myanmar's least studied dryland ecosystems, including Dry Thorn Forest (DTF) and Than-Dahat Forest (TDF), which support unique biodiversity and ecosystem functions. This study assessed long-term changes in the extent, fragmentat...

Conceptual Design and Preliminary Embedded Applicability Evaluation of an AI-Based Predictive Maintenance Residual Current Device Using Time-Series Analysis of Leakage Current

This study proposes a conceptual AI-based predictive maintenance architecture for residual current devices (RCDs) using time-series analysis of leakage current and evaluates the preliminary embedded applicability of deep learning models. Leakage current data were collected at 1 s...

Internal Coherence Across the Components of Türkiye's 2024 History Curriculum

This study examines internal coherence among the learning outcomes/process components, content framework, teaching and learning practices, and evidence of learning in Türkiye's 2024 History Curriculum for Grades 9–11. The study employed qualitative document analysis of the offici...

Attenuated GlycoRNA-microglial transcriptional coupling in the dorsolateral prefrontal cortex of patients with major depressive disorder: an exploratory interaction-based in-silico analysis

Abstract Background: Glycosylated RNAs (GlycoRNAs) participate in immune recognition and intercellular communication, but their relationship with brain cell-type transcriptional signatures in major depressive disorder (MDD) remains unclear. We examined GlycoRNA-related transcript...

COOLANT++: concept-bank alignment and confidence-gated reasoning for multimodal fake news detection

Model and training pipeline accompanying the Scientific Reports article “COOLANT++: Concept-Bank Alignment and Confidence-Gated Reasoning for Multimodal Fake News Detection.” The release implements the shared cross-modal concept bank, confidence-gated reasoning unit, training los...

Verification and calibration of volume forecasts in petroleum exploration: insights from the Norwegian Continental Shelf

Exploration decisions rely on pre-drill volume estimates that shape drilling choices, portfolio ranking, and economic appraisal. This study evaluates the reliability and accuracy of such forecasts and tests whether simple calibration can improve them. Using prospect-level forecas...

Quantifying the heterogeneity of deep-water depositional environments for CO 2 storage: an outcrop-based example from the Hecho Group (Spanish Pyrenees)

Characterising heterogeneity at a range of scales for CO 2 storage is critical to balance reservoir quality (net storage and injection feasibility) against internal trapping efficiency. Here, the deep-water Banastón System (Middle Eocene Hecho Group) of the South Pyrenean Forelan...

Marx and the Machine Revisited: Rethinking Exploitation Beyond Technological Fetishism

Abstract Both mainstream and heterodox conceptions of modern technology suffer from ‘machine fetishism’: the illusory perception that technological devices are productive or powerful in themselves , rather than as products of global relations of exchange. A cognitive foundation f...

Enacting sports-education integration in Chinese sports schools: evidence from three schools in Henan Province

China’s sports schools are undergoing critical institutional reform under the national agenda of sports-education integration (ti jiao ronghe). Long positioned within the state-led elite sport system, sports schools are increasingly expected to reconcile elite youth sport trainin...

Variation in care provision for dislocation of hip replacement: a national UK survey

Abstract Background Dislocation is a severe complication after total hip replacement (THR), with multifactorial causes, and characterised by severe pain, reduced quality of life, poorer function and long-term psychological impact. Patients have reported variability in care experi...

Putting others first: testing a model of prosociality and performance

Abstract Employees reshape their roles to help others; yet existing theories explain either proactive self-directed job redesign or prosocial behavior within existing role boundaries. We introduce Prosocial Job Crafting (PSJC), a distinct form of role-based job crafting through w...