Research works

Hyperactivity in context: comparing actigraphy and informant ratings across the school week

Background Hyperactivity is a core symptom of childhood attention deficit hyperactivity disorder (ADHD), yet no population‐based studies have compared objective and subjective hyperactivity measures across the school day. Methods This study used data from N = 6,518 seven‐year‐old...

Adaptive Eigenvector Continuation for Full-Vector Photonic Waveguide Mode Emulation

Photonic waveguide design often requires repeated full-vector Maxwell eigenmode solves over wavelength, geometry, and material parameters. We present an adaptive eigenvector-continuation framework for accelerating and stabilizing these modal sweeps. The method constructs a reduce...

Entropic Dynamics of Jump-Diffusion Option Pricing

The standard models of stock-price dynamics and option valuation rest on stochastic processes postulated at the outset; here, we lay down an entropic-inference framework that derives these processes rather than assuming them, by making explicit the information each one encodes. A...

Method for Controlling the Exposure of (312) Crystal Plane in Ni12P5 Nanoparticles and Its Impact on the Catalytic Dechlorination Activity of Trichloroethylene

Transition metal phosphides (TMPs) have gained significant attention from researchers in the field of catalytic hydrogenation due to their excellent properties. However, existing studies have rarely explored the targeted regulation of the degree of crystal plane exposure of the N...

Modeling Reliability and Validity Across OSCE Station Numbers in Final MBBS Exam

Background: The Objective Structured Clinical Examination (OSCE) has been the backbone of assessment in medical education, and the number of stations required to achieve sufficient reliability in high-stakes examinations is an important consideration for resource-limited programs...

Exact matrix-free streaming enables global phosphosite co-variation mapping without quadratic result materialization

Reproducibility package for the Scientific Reports revision of the manuscript “Exact matrix-free streaming enables global phosphosite co-variation mapping without quadratic result materialization.” This clean-room package reproduces the principal computational and empirical resul...

Predictive processing as a scalable computational principle for embodied multitask intelligence

Humans exhibit remarkable flexibility in adapting to diverse and uncertain environments—a hallmark arising from the brain’s ability to integrate multimodal sensory streams into coherent predictive models. Drawing on this principle, we introduce a scalable hierarchical multimodal...

Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity

Abstract Background/Objectives Glioblastoma is an aggressive primary brain tumor that develops within a chronically low-oxygen microenvironment, yet most preclinical studies are performed under atmospheric oxygen conditions that poorly reflect in vivo physiology. This study inves...

Yu-Shiba-Rusinov-assisted Andreev transport in a molecular junction between superconductors

Magnetic impurities in superconductors host Yu-Shiba-Rusinov (YSR) bound states, whereas weak superconducting junctions sustain subharmonic charge transport through multiple Andreev reflections (MAR). We explore these phenomena using a molecular-scale junction created by placing...

Subclinical Cardiac Dysfunction in Children with Iron Deficiency Anemia Assessed by Tissue Doppler and Speckle-Tracking Echocardiography

OBJECTIVE: Iron deficiency is the leading cause of anemia in childhood and may induce cardiovascular adaptations, including increased heart rate, elevated cardiac output, plasma volume expansion, and myocardial remodeling. Beyond hematologic consequences, reduced iron availabilit...

Endothelin-Dependent Myocardial Dysfunction in an Experimental Endotoxic Shock Model

OBJECTIVE: Impaired myocardial contractility is a major contributor to cardiovascular failure during septic shock; however, the underlying mechanisms remain incompletely understood. This study investigated the roles of endothelin and nitric oxide (NO) in cardiac dysfunction using...

Enhanced extracellular invertase production in Bacillus subtilis by boosting synthesis and secretion in a suitable chassis cell

<title>Abstract</title> Background Soybeans are an important agricultural product, but they contain a significant amount of raffinose, which can cause flatulence when fermented by intestinal microorganisms. Invertase InvDz13 from <italic>Microbacterium trichothecenolyticum</itali...

Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR

Adhesion G protein–coupled receptors (aGPCRs) transduce signals via engagement of their large extracellular regions (ECRs) with adhesion partners. ADGRG6 (GPR126) is an aGPCR vital for the development of multiple organs and myelination. ECR conformational dynamics of ADGRG6 has b...

From Fog Chamber to Aircraft Window: Pixel-Registered Imaging and Synthetic Fine-Tuning Enable Cross-Domain Defogging

A deep defogging pipeline pretrained on controlled laboratory fog and fine-tuned with domain-randomized synthetic fog applied to clear outdoor scenes generalizes across a graded sequence of out-of-distribution settings with no target-domain training, from chamber-free free-flowin...

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major opportunistic pathogen whose clinical management is increasingly compromised by antibiotic resistance and biofilm-associated persistence. Anti-pathogenic strategies that attenuate virulence without inhibiting bacterial growth offer a promising al...

Spiky Bursts of Energetic Electron Beams Upstream of Nonstationary Quasi‐Perpendicular Shocks

Abstract Energetic electron beams play a crucial role in collisionless shocks by driving upstream plasma waves and providing seed populations for diffusive shock acceleration. However, the processes responsible for their generation at quasi‐perpendicular shocks remain poorly unde...

Occurrence and controls of ~ 1 Hz waves in Mercury’s magnetosphere: insights from MESSENGER observations

<title>Abstract</title> Mercury’s magnetosphere is highly dynamic, with processes occurring on much shorter spatial and temporal scales than at Earth due to its weak magnetic field and proximity to the Sun. Wave-driven transport of energy and momentum is a key manifestation of th...

Racial and Ethnic Differences in Classic and 11-Oxygenated Androgens in Men

BACKGROUND: Androgen-dependent prostate pathology, including prostate cancer and benign prostatic hyperplasia, differs in prevalence and phenotype across races/ethnicities. Adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) are relevant to several androgen-dependent pat...

Aortitis as a High-Risk Vascular Syndrome: Integrating Phenotype-Driven Diagnosis, Multidisciplinary Assessment, and Personalised Management

Aortitis—inflammation of the aortic wall—presents at the interface of vasculitis, infection, structural aortic disease, and cardiovascular risk. It may occur in giant cell arteritis (GCA), Takayasu arteritis, IgG4-related disease, drug-induced injury, infection, or as an isolated...

Context-Aware Maritime Navigation Efficiency Assessment: A Data-Fusion Framework with Metocean and Encounter-Based Validation

Maritime navigation efficiency is commonly assessed using isolated indicators such as route deviation, speed variation, fuel-related metrics, or traffic density, which do not fully reflect the operational context of a voyage. This study proposes a context-aware framework for asse...