Research works

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Smart Cardiac ICU: Digital Integration, Predictive Analytics, and Perioperative Inflammation

Contemporary intensive care is operating in an environment with high complexity cases, large volumes of information, and vast physiological, biological and therapeutical data, collected from laboratory results, investigations, therapies for organ support, collected from systems t...

Overcoming Perfusion Impairment in the Ischemic Brain: A Review

Perfusion impairment is one of the major barriers to using machine perfusion to prepare brain tissue for research and clinical applications. As ischemia progresses, multiple mechanisms, including intravascular obstructions, perivascular cellular edema, mural cell contraction, and...

Effect of High-Energy Excimer Treatment of Ti-Based Alloys on Cytocompatibility and Antibacterial Properties

The study investigates the effects of high-energy laser treatment on titanium-based alloys, TiAlV, TiNbZr, and TiNbSnTa, materials of high interest for medical applications such as implants and dental devices due to their exceptional strength-to-weight ratio, corrosion resistance...

Impact of the COVID-19 Pandemic on Presentation, Microbiology, and Outcomes of Infective Endocarditis: A Romanian Retrospective Cohort Study

Objectives: This study aimed to assess the impact of the COVID-19 pandemic on the epidemiology, microbiology, clinical presentation, management, and outcomes of infective endocarditis (IE). Methods: A retrospective cohort study was conducted, including 100 adult patients with def...

From Travel Narratives to Cultural Routes: Interpreting via Egnatia as a Heritage Corridor

Cultural Routes have become important instruments for promoting shared heritage and sustainable tourism across Europe, yet the potential of travel literature to inform their development remains underexplored, particularly in the case of Via Egnatia. This study addresses this gap...

Temperature-Dependent Chemical Profiles of Pyroligneous Liquor Fractions from a Kiln-Furnace System

Pyroligneous liquor (PL) is a by-product of charcoal production with potential applications in agriculture, forestry, and industry. This study evaluated the influence of carbonization temperature on the yield, chemical composition, and physicochemical properties of PL obtained fr...

Drone-based assessment of humpback and fin whale vessel-strike vulnerability

Collisions with vessels (vessel-strikes) are one of the largest threats to the recoveries of baleen whale populations worldwide. Vessel-strike vulnerability is complex, depending on a vessels size and speed, and the presence, position, visibility, and movement of whales. To date,...

Quantum pyramidal cosmology: emergent universe from ternary quantum chaos

Comprehensive Edition v9 of Quantum Pyramidal Cosmology (QPC) — a self-consistent model in which the observable Universe emerges from ternary quantum chaos. This edition adds rigorous information-theoretic foundations for the Aura Functional via quantum relative entropy, establis...

Pain as Restrictive Biological Reorganization: A Dynamical Formalization of Action Domain Restriction

Recent naturalistic and enactivist proposals have reinterpreted pain as biological reorganization of the living system, grounded in the Biology of Cognition and non-dualist frameworks that treat pain as a structural modification of the organism rather than a mental representation...

A Moving-Cut Correction to the Huang–Li Conditional Goldbach Argument: Consequences for Diagonal Möbius-Twisted Elliott–Halberstam Hypotheses

This note identifies and repairs a moving-cut omission in the large-divisor rearrangement used in Huang and Li's conditional argument for the binary Goldbach conjecture. Under the substitution k=(N−n)/d, the condition d>α becomes k<(N−n)/α; after reversing the order of summation,...

Agricultural Value Addition and Structural Transformation in a Developing Agrarian Economy: Evidence from Bihar, India

Agricultural value addition and structural transformation are central to sustainable rural development in developing agrarian economies. Although Bihar remains predominantly dependent on agriculture, existing studies have focused mainly on production growth, technological change,...

ProtPen CombinesSequence- and Structure-based Approachesto Facilitate Protein Function Predictions on a Proteome-wide Scale

Abstract Proteins of unknown function represent a significant gap in our understanding of biological processes, encompassing large portions of the proteomes of many organisms, especially prokaryotes. Addressing this gap is critical to understanding the biology and pathogenicity o...

From Physical Grids to Cyber-Energy Digital Twins: Modeling Power System Components for Cyberattack Assessment

Traditional Digital Twins (DTs) in energy sectors lack cyber-threat awareness, while cybersecurity DTs overlook downstream physical impacts. Loosely coupled co-simulations attempt to bridge this gap but introduce computational lags that mask critical cross-domain vulnerabilities....

Quality of Life Outcomes in Patients with Pulmonary Hypertension Receiving Prostacyclin Therapy: Impact of Anxiety, Depression, Sociodemographic Characteristics, and Treatment-Related Factors

OBJECTIVE: Despite advances in prostacyclin therapy, pulmonary hypertension (PH) continues to impair patients' quality of life (QoL). This study aimed to identify the clinical and psychological factors associated with QoL in patients receiving prostacyclin therapy. METHOD: This c...

Eastern European–Asian Cooperation: Aquacultural and Cultural Contributions to Increased Fish Consumption in Laos

Laos is one of the 32 landlocked developing countries (LLDCs) of the world, where isolation from the sea and the lack of a large-scale fishing industry have a direct effect on fish supply and fish consumption. Per capita fish consumption in LLDCs amounted to 5.1 kg/year in 2023,...

Data-driven prediction of fifteen-year all-cause mortality among 2.3 million individuals in the VA

ABSTRACT We present a data-driven framework to predict 15-year all-cause mortality using outpatient administrative records for 2.3 million Veterans in the largest integrated U.S. healthcare system. Rather than relying on predefined clinical phenotypes, we used the 1,000 most comm...

GANCIU—Geospatial Analysis with Neural Classification and Image Understanding

Accurate and up-to-date knowledge of land use and land cover represents one of the central challenges in spatial planning and landscape sciences. In this context, the present work introduces GANCIU (Geospatial Analysis with Neural Classification and Image Understanding), an origi...

A Decision-Diagram Framework for Conflict Detection in Multi-Layer Cilium Network Policies

Cilium is among the most widely deployed Container Network Interfaces (CNIs), serving as the default CNI in the Google Kubernetes Engine. It extends standard Kubernetes NetworkPolicy (KNP) with two additional types—CiliumNetworkPolicy (CNP) and CiliumClusterwideNetworkPolicy (CCN...

Artificial Intelligence Connectedness: Theoretical Reconstruction of Connectedness and Its Impacts on Adolescent Mental Health

The widespread penetration of generative artificial intelligence is reshaping adolescents’ social ecosystems and emotional experiences, while challenging the interpretive boundaries of traditional connectedness theories. Following the logical path of “connotation reconstruction–e...