Research works

Ball‐Milling‐Enabled Solvent‐ and Ligand‐Free Tsuji–Trost Reaction of C ‐, N ‐, O ‐, S ‐, and Se ‐Nucleophiles in Air: Synthesis and Late‐Stage Modification of Drugs

We report a novel ball‐milling‐enabled, ligand‐free Tsuji–Trost reaction involving C ‐, N ‐, O ‐, S ‐, and Se ‐nucleophiles with allyl and cinnamyl acetates, as well as allyl phosphate. Thiophenols and benzeneselenol have been demonstrated for the first time as nucleophiles in a...

Plurality Is Not the End Point: From Civilizational Coexistence to Civilizational Integration—Non-Coercive Integration, Cultural Evolution, and the Formation of a Shared Civilizational Layer

Cultural diversity is a basic reality of human civilization and an important source of knowledge, meaning, identity, and creativity. Yet acknowledging civilizational plurality does not answer a further question: must different civilizations remain permanently parallel, or can lon...

Prescription Denials For GLP-1 Receptor Agonists Across Commercial, Medicare, And Medicaid Coverage, 2018–2024

Structured Abstract Background Access to GLP-1 receptor agonists (GLP-1 RAs) remains strongly shaped by payer coverage and utilization management. Patient-level evidence on GLP-1 RA denial across payer types is limited. Methods Using a national multi-payer claims database capturi...

Human-AI Decision Support: Cost Structure of Explanation-Centric Workflows

Research article: Human-AI Decision Support: Cost Structure of Explanation-Centric Workflows

Kahramanmaraş/Andırın ağzı şekil özellikleri (isim ve zamir çekimleri)

Oğuz boylarının Anadolu’nun farklı bölgelerine yerleşmeleri, geçmişten günümüze ağız farklılıklarının oluşumunda belirleyici bir etken olmuştur. Yerleşim süreciyle birlikte her bölge, sosyal, kültürel ve coğrafi koşulların etkisiyle kendine özgü ağız özellikleri geliştirmiştir. B...

Creatinine and urine-output criteria and subsequent kidney progression in critically ill adults with cirrhosis: a two-database 24-hour landmark study with alternative weight definitions

Abstract Background Serum creatinine and urine output can identify different manifestations of acute kidney injury (AKI) in cirrhosis. We examined their joint association with subsequent kidney progression and the influence of the body-weight definition used to index urine output...

Novel therapeutics for platinum-resistant ovarian cancer: from biological mechanisms to emerging biomarker-guided strategies

For decades, platinum resistance has remained one of the major barriers to improving outcomes in ovarian cancer. Patients with platinum-resistant ovarian cancer (PROC) generally have shorter overall survival and lower response rates to second-line treatment than those with platin...

Optimization of low velocity impact parameters of thermoplastic based fiber metal laminate composites using Taguchi based desirability function approach

Fiber metal laminates (FMLs) combine the high specific strength and damage tolerance of metals with the light weight and fatigue resistance of fiber-reinforced composites, overcoming key limitations of conventional monolithic materials. Replacing thermoset matrices with thermopla...

Long-Term Treatment Retention of Levetiracetam Monotherapy in Adults with Epilepsy: A 10-Year Retrospective Cohort Study Using Time-to-Treatment-Failure Analysis

Background: This study aimed to estimate treatment retention rates for levetiracetam monotherapy in patients with epilepsy and to characterize treatment failure in this population. Methods: A retrospective cohort study included 769 adult patients with epilepsy between 2015 and 20...

A study analyzing factors retarding digital transformation and configuration pathways: Based on the perspective of digital transformation acceptors

The high-touch service nature of the hospitality industry highlights that the success of digital transformation depends primarily on human factors rather than technology itself. Existing research indicates that approximately 80% of strategic initiatives fail due to employee resis...

Field monitoring and modelling of sediment transport, hydraulics and hydro-abrasion at the Mud Mountain Sediment Bypass Tunnel in the USA

Sediment Bypass Tunnels (SBTs) reduce or even stop reservoir sedimentation by routing sediment-laden flows around reservoirs, mainly in mountainous regions with gravel bed rivers. High sediment loads and flow velocities can cause hydro-abrasion on SBT inverts, leading to costly m...

When Currencies Drift: Real Exchange Rate Misalignments and Economic Growth

Abstract Persistent deviations of exchange rates from their equilibrium values have long been viewed as a source of macroeconomic instability, yet there remains little consensus on when and under what conditions exchange rate misalignments affect long-term economic growth. This p...

HERStory: development and process evaluation of a manualized drama therapy intervention for women with breast cancer

Abstract Despite increasing recognition of creative arts therapies within psycho-oncology, manualized drama therapy interventions remain scarce. This article introduces HERStory, a six-session drama therapy group intervention for women with breast cancer, combining the Heroine’s...

Integrating Lynch syndrome management into routine cancer pathways: a lifespan-oriented approach to patient-centred care and shared decision-making

Abstract Background Lynch syndrome is one of the most common inherited cancer predispositions. Widespread implementation of tumour-based screening and increased awareness and availability of germline genetic testing has substantially increased identification of individuals with L...

Pelvic Floor Muscle Training Outperforms Pilates in Women with Stress Urinary Incontinence: A Randomized Controlled Trial

Abstract Introduction and Hypothesis The objective was to compare the effects of a Pilates exercise program performed with or without voluntary pelvic floor muscle contraction versus pelvic floor muscle training (PFMT) on urinary incontinence impact and pelvic floor muscle functi...

Workers’ internal locus of control and labour market mismatch

This paper examines the relationship between workers’ internal locus of control (ILOC) and education and skill mismatch. Using German survey data, we distinguish subjective and objective education mismatch and self-reported skill mismatch and account for cognitive ability and oth...

Parental participation in empirical studies about sexual health: a systematic review of challenges and opportunities

Abstract Working with parents to improve the sexual health of adolescents is a popular and promising strategy. As it can be challenging, this review aimed to identify and synthesize barriers to and facilitators of parental participation in empirical studies about adolescent sexua...

Tissue Factor Expression Is Associated with Distinct Pattern of Immune-Cell Infiltration in the Ovarian Tumor Microenvironment

Tissue factor (TF) has been implicated in tumor progression and immune regulation, but its cellular sources and relationship with immune infiltration in ovarian cancer remain incompletely defined. We integrated single-cell RNA sequencing (GSE232314), analyses of The Cancer Genome...

COMMON GRAMMATICAL ERRORS MADE BY UZBEK LEARNERS OF ENGLISH: A DESCRIPTIVE ANALYSIS AND PEDAGOGICAL IMPLICATIONS

This study investigates the most prevalent grammatical errors made byUzbek learners of English as a Foreign Language (EFL) and examines the underlyinglinguistic mechanisms driving these errors. Utilizing an error analysis (EA) frameworkcombined with Contrastive Analysis (CA), the...

Demographic, socioeconomic, and geographic predictors of treatment utilization and survival in Merkel cell carcinoma: an analysis of the national cancer database

Abstract Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with a mortality rate exceeding that of melanoma. While previous studies have examined frequencies, the influence of demographic factors on treatment likelihood and survival is limited. The Nati...