Research works

Biogeochemical dichotomy and intra-order variability in Miliolid and Rotaliid foraminifera

Abstract. Foraminiferal geochemical records reflect both environmental and biological influences. Disentangling these factors is essential for improving their application in marine monitoring and contributing valuable insights into the evolution across major foraminiferal lineage...

Evaluating the knowledge, attitudes, and perceptions of the musculoskeletal anatomy of the back among health professionals: A cross-sectional needs assessment study

A strong grasp of musculoskeletal (MSK) anatomy of the back is essential for clinical competence, diagnostic accuracy, and procedural safety. Persistent knowledge gaps among healthcare professionals, along with reduced curricular emphasis and inconsistent reinforcement, have been...

A Novel Differential Pathlength Factor Model for Near-Infrared Diffuse Optical Imaging

Near infrared diffuse optical imaging can be performed in reflectance and transmission mode and relies on physical models along with measurements to extract information on changes in chromophore concentration. Continuous-wave near-infrared diffuse optical imaging relies on accura...

Use of Generative Artificial Intelligence for Consultation Preparation in Shared Decision Making: Can a Handbook Provide Support?

Background: Shared Decision Making (SDM) is considered the gold standard of patient-centered care but often fails in clinical routine due to time constraints and a lack of patient preparation. While patients often struggle to articulate their preferences and questions, new develo...

Neuropeptide diversity and evolutionary patterns in crustaceans: insights into adaptations, agonism, and functional importance in organs

<title>Abstract</title> Background Crustaceans exhibit great diversity in anatomical, physiological, and behavioral adaptations, all of which contribute to their evolutionary success, and neuropeptides are important regulators mediating these adaptations. While expansion of certa...

Lost balance: synergy-redundancy dysfunction in Alzheimer’s disease

<title>Abstract</title> Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet reliable early biomarkers are still lacking, which greatly hinders timely intervention for AD. This study employed an integrated information decomposition framework to systematical...

Atomic clocks and gravitational waves as probes of non-metricity

Abstract Non-metricity provides a natural extension of Riemannian geometry, yet its experimental signatures remain largely unexplored. In this work we investigate how spacetime non-metricity can be probed through high-precision observations, focusing on atomic clocks and gravitat...

CRISPR-Cas9-induced genetic mosaicism in three species of the microcrustacean Daphnia

Abstract Genetic mosaicism can arise from in vivo CRISPR-Cas9 gene editing, especially in the embryos. This study evaluates the extent of genetic mosaicism resulted from CRISPR-Cas9-mediated knockout for 11 genes in the freshwater microcrustacean Daphnia magna, D. pulex , and D....

Inversion Problem in Algebras of Integrable Functions With Summable Fourier Transforms

ABSTRACT In this paper, we study the norm‐controlled inversion problem in two classes of algebras of integrable functions. In contrast of the classical case of , we prove that this problem has a positive solution in our setting without any additional restrictions.

Convolutional LSTM surrogate for mesoscale hydrocode simulations of granular wave propagation

Granular materials subjected to impact loading exhibit heterogeneous spatiotemporal dynamics governed by stress-wave propagation, pore collapse, and grain-scale rearrangement. Mesoscale hydrocodes can resolve these mechanisms, but the computational cost of repeated simulations li...

Implementing methane dynamics into the LPJmL6 model

Abstract. We extend the Dynamic Global Vegetation Model LPJmL to version 6.0 by explicitly representing methane (CH4) dynamics within the coupled carbon–nitrogen–water system. The implementation (i) prognoses water-table depth and wetland extent using a CTI–TOPMODEL framework, (i...

Structural rearrangements underlying the activation of STIM1 by ER calcium depletion

ABSTRACT In resting cells, STIM1, the dimeric ER Ca 2+ sensor that controls store-operated Ca 2+ entry (SOCE), is held in a Ca 2+ -bound inactive state by multiple intramolecular restraints, or brakes. Receptor-evoked release of Ca 2+ from the ER causes a large conformational cha...

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

<title>Abstract</title> Intracellular pathogens are ideal candidates for modelling the pathophysiology of chronic infection, as they hide within host cells and avoid conventional immune clearance through a controlled reshaping of cellular fate. This study unveils how the emerging...

Why Is the Mental Health of the Youngest American Workers in Decline?

The worsening mental health of young workers drives what appeared to be the disappearance of the age-related U-shape in wellbeing and the hump-shape in illbeing over the last decade. Using repeat cross-sectional data, we show that, whilst illbeing remains hump-shaped among non-wo...

SuPerPoV: Score and Evolution of the Stratospheric Polar Vortex via Persistent Homology

Abstract Classifying the stratospheric polar vortex provides predictability for surface weather on extended‐range timescales. However, all definitions of these events proposed in over 60 years of study depend on empirically chosen parameters and yield different results when they...

Capturing the Epistemic Uncertainty in Subduction Earthquake Rupture Parameters

ABSTRACT Subduction earthquakes are highly destructive and can trigger devastating tsunamis, highlighting the need for a consistent probabilistic seismic-tsunami hazard assessment. However, current approaches treat both hazards separately: tsunami models use static coseismic slip...

A near-sunset atmospheric sounding during the 14 October 2023 annular solar eclipse over Natal

Abstract. Solar eclipses are transient atmospheric events that cause rapid localized reduction in solar radiation, which produces complex changes associate with the vertical coupling of the layers. This study investigates the vertical response of the neutral atmosphere to the 14...

Super-resolution CT-based intratumoral and peritumoral radiomics analysis for trinary classification of PD-L1 status in lung adenocarcinoma ≥ 1 cm

<title>Abstract</title> Objectives To explore the potential of super-resolution CT-based intratumoral and peritumoral radiomics analysis for the trinary classification of PD-L1 status in lung adenocarcinoma with a diameter of ≥ 1cm, aiming to enhance the accuracy of PD-L1 status...

Hamiltonian Dynamics as the Engine of Biological Computation: Linking Gamma Oscillations to Scale-Inseparable Memory

This study investigates the physical basis of biological computation, focusing on the tension between static structuralism and dynamic evolution. Utilizing a Hamiltonian formulation of the Kuramoto model, we simulate a biological reservoir to rigorously evaluate the relationship...

A Computational Toy Model of Non-Local Information Storage in a Quantum Cellular Automaton

The holographic principle, which posits that the physics of a volume of space can be encoded on its boundary, has been profoundly reinterpreted as a form of quantum error correction. Separately, Quantum Cellular Automata (QCAs) offer a bottom-up model for the emergence of complex...