Research works

Commensal Lachnospiraceae bacterium mitigates colitis-induced mucin fucosylation deficits through ILC3/IL-22 axis

Flagellins from commensal bacteria are potent modulators of intestinal immunity, yet their strain-specific functions, particularly in promoting homeostasis in ulcerative colitis (UC), remain poorly defined. We investigate whether flagellin from the commensal Lachnospiraceae bacte...

Gold Nanoparticle-Enabled Cancer Therapy: Translational Design Rules for Photothermal–Immunotherapy and Multimodal Precision Oncology

Gold nanoparticles (AuNPs) are versatile cancer-therapy platforms with tunable plasmonic properties, high atomic number, accessible surface chemistry, and potential for integration into theranostic systems. By controlling size, morphology, surface composition, and cargo-loading s...

Manufacturing Process Innovation Through Design of Experiment for UHMWPE Powder Consolidation Using Autoclave Processing

ABSTRACT UHMWPE has been a material of choice for orthopedic surgeons in treating joint‐related problems since its introduction by Sir John Charnley in the 1960s. However, the high melt flow index of the material makes it difficult to process using conventional techniques of poly...

Imaging-based biological age estimation predicts competing mortality risk in lung cancer screening

Abstract Lung cancer screening (LCS) participants have a high competing risk of non-lung cancer related death, which limits screening benefit. We hypothesized that imaging-based biological age can identify individuals at higher risk of non-lung cancer mortality. Low dose computed...

Bilateral Congenital Absence of the Anterior Cruciate Ligaments in an Adolescent Male: A Rare Clinical Presentation and Review

A 16-year-old male presented with bilateral knee instability and intermittent pain without any history of trauma or surgery. Clinical examination revealed positive Lachman and anterior drawer tests bilaterally. Magnetic resonance imaging demonstrated complete bilateral absence of...

Graph Neural Networks (GNNs) for Complex System Anomaly Detection and Cybersecurity Telemetry: Topologies, Temporal Dynamics, and Enterprise SOC Benchmarks

Abstract—Modern enterprise computing fabrics, cloud infrastructures, and Security Operations Centers (SOCs) are inundated by billions of security events daily. Conventional Security Information and Event Management (SIEM) engines and intrusion detection systems (IDS) analyze tele...

Speculating on Speculation? Thinking Within and Beyond the Mortgage Present a Reply to the Comments on ‘Envisioning Mortgage Futures’

This piece replies to some fine scholarship from the five commentators who have taken up the pen in response to our focus article. We take up four themes running through the commentaries: the novelty of the imagined future, the politics of prediction, the social life of the score...

Evaluating the Role of MC1R Variants in Cutaneous and Ocular Phenotypes: A Candidate TYR–MC1R Genetic Interaction in Oculocutaneous Disorders

Background: The melanocortin-1 receptor (MC1R) gene is a major determinant of skin and hair color. Although several MC1R variants increase the risk of skin tumors regardless of pigmentation, their role as genetic modifiers in ocular diseases remains poorly understood. Methods: He...

Cognitive Biases and Moral-Regulatory Mechanisms in White-Collar Crime: A Systematic Review and Bibliometric Mapping of Psychological Pathways to Corporate and Financial Misconduct

White-collar crime causes major economic and social harm, yet research on its psychological mechanisms remains fragmented across criminology, behavioral ethics, accounting and finance. To synthesize research on cognitive biases and moral-regulatory mechanisms underlying white-col...

Berberine Protects Brain Endothelial Barrier via β-Catenin: A Network Pharmacology in Pigs and In Vitro Mechanistic Analysis

Glaesserella parasuis (G. parasuis) is an important swine pathogen that causes Glässer’s disease, of which meningitis is among the most severe clinical symptoms. However, the molecular mechanisms underlying G. parasuis-induced meningitis remain poorly understood. In this study, w...

High‐Density Magnetomyography With Optical Magnetometers Reveals Spatiotemporal Patterns of Evoked Muscle Activity

ABSTRACT Magnetomyography (MMG) holds great potential as a contactless alternative to electromyography (EMG). However, the spatiotemporal dynamics of the myomagnetic field in vivo remain largely unknown, limiting signal interpretability and hence the use of MMG. Here, the myomagn...

Strengthening infection prevention education among undergraduate nursing students through a curriculum-integrated escape room intervention: A comparative cohort study

Aim/objective To examine whether a curriculum-integrated IPC escape room was associated with improved undergraduate nursing students’ knowledge. Methods and results This comparative cohort study included 318 fourth-semester nursing students in a control cohort ( n = 163) and an i...

A defect and multi-physics informed neural network for fatigue life prediction in friction stir welded additive manufacturing AlSi7Mg

Additively manufactured aluminium alloys joined by friction stir welding exhibit great potential for large-scale structural applications, yet their fatigue life prediction remains challenging due to the complex influence of internal defects and process-induced microstructural het...

An interior second-order defect from a Hele-Shaw contact arc

A detailed attributed proof/application of Ross–Witt Nyström's smooth Hele-Shaw contact-arc construction. The associated bounded weak homogeneous complex Monge–Ampère solution on P1 times the disc lacks a second-order real Taylor expansion at a genuine interior point, despite smo...

Photodynamic Therapy‐Primed and Enzyme Cascade‐Fueled in Situ Prodrug Self‐Assemblies for Self‐Amplifying Chemotherapy

ABSTRACT Tumor heterogeneity remains a major translational challenge for targeted therapies, particularly those employing multi‐targeted precision strategies. To overcome this barrier and ensure both high tumor‐specificity and robust clinical efficacy, we designed CBT‐NM‐PPa‐cRGD...

Heat transfer optimization in MHD trihybrid nanofluid flow over a stretching Riga surface with Cattaneo–Christov heat flux

This study presents the heat transfer analysis of magnetohydrodynamic trihybrid nanofluid flow over a stretching Riga surface configuration and the Cattaneo–Christov non-Fourier heat flux model. The electrically conducting $${\text{Al}}_{{2}} {\text{O}}_{{3}}$$ –Cu– $${\text{TiO}...

EuroMillions Breakthrough Mining — 10370 Sources, 101077 Leads Extracted — E8 Intelligence Research

Mined 10370 lottery+quantum breakthroughs. Extracted 101077 leads across 13 categories. 97408 high-value leads found. Categories: {"CORRIDOR": 8835, "FORMULA": 8588, "GEOMETRIC": 1703, "FORWARD_ATTEMPT": 9284, "QUANTUM": 9537, "TIMING": 647, "CELESTIAL": 8653, "GEMATRIA": 9066, "...

A vision-based docking planning network for robust recovery of autonomous underwater vehicles

Autonomous Underwater Vehicles (AUVs) are core intelligent platforms in fields such as marine resource exploration and offshore engineering operations. Stable underwater autonomous recovery technology is crucial for ensuring the continuous safety and efficient operation of AUVs....

Evaluation of Stretchability in Displays: Overall and Local Stretch‐Recovery Properties

ABSTRACT Stretchable displays, increasingly recognized in wearable electronics and stretchable control systems like the jog dial in automotive systems, require both high stretchability and efficient recovery. However, as each scenario adopts its own customized evaluation method o...

Environmental determinants of phenazine- and 2,4-diacetylphloroglucinol-producing Pseudomonas in the wheat rhizosphere across a precipitation gradient

ABSTRACT The Columbia Plateau of the Inland Pacific Northwest (IPNW) encompasses one of North America’s largest dryland wheat production regions, where soil moisture strongly influences plant growth, health, and rhizosphere microbial communities. Two ecologically and genetically...