Research works

Evaluating noises of fast-simulated boson sampling with statistical benchmark methods

Abstract It is important to know noise levels of boson sampling in order to cautiously demonstrate the quantum computational advantage or realize certain tasks. Based on those statistical benchmark methods such as the correlators and clouds, which are initially proposed to discri...

Prohibitin 1 orchestrates mitochondrial-ER crosstalk via the VDAC1-GRP75-IP3R axis to drive malignancy in gastric cancer

<title>Abstract</title> <bold>Background</bold>: Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), serving as critical hubs for mitochondrial- ER interactions, play a pivotal role in cancer progression. Prohibitin 1 (PHB1), an inner mitochondrial membrane prote...

Challenges in deep learning-based small organ segmentation: A benchmarking perspective for medical research with limited datasets

Accurate segmentation of carotid artery structures in histopathological images is vital for cardiovascular disease research. This study systematically evaluates ten deep learning segmentation models including classical architectures, modern CNNs, a Vision Transformer, and foundat...

Gromov–Wasserstein Barycenters: The Analysis Problem

Abstract. This paper considers the problem of estimating a matrix that encodes pairwise distances in a finite metric space—or, more generally, the edge weight matrix of a network—under the barycentric coding model with respect to the Gromov–Wasserstein (GW) distance function. We...

Efficient Discovery of Motif Transition Process for Large-Scale Temporal Graphs

Understanding the dynamic transition of motifs in temporal graphs is essential for revealing how graph structures evolve over time, identifying critical patterns, and predicting future behaviors, yet existing methods often focus on predefined motifs, limiting their ability to com...

Integral Artin motives II: Perverse motives and Artin Vanishing Theorem

In this text, we are mainly interested in the existence of the perverse motivic t-structures on the category of Artin étale motives with integral coefficients. We construct the perverse homotopy t-structure which is the best possible approximation to a perverse t-structure on Art...

Minimum Partition of Polygons under Width and Cut Constraints

We study the problem of partitioning a polygon into the minimum number of subpolygons using cuts in a fixed set of directions such that each resulting subpolygon satisfies a given width constraint. A polygon satisfies the unit-width constraint for a set of directions if the lengt...

A systematic review of early neuroimaging and neurophysiological biomarkers for post-stroke mobility prognostication

Abstract Background Accurate prognostication of mobility outcomes is essential to guide rehabilitation and manage patient expectations. The prognostic utility of neuroimaging and neurophysiological biomarkers remains uncertain when measured early post-stroke. This systematic revi...

Mathematical modeling for a primitive form of habituation in an amoeba

Abstract Learning abilities, once thought to be unique to higher animals, have been reported to exist in their primitive form in single-celled organisms. This has triggered a growing interest in carefully examining the nature and mechanisms of the primitive versions of learning a...

Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics

Ovarian high-grade serous carcinoma (HGSC) is an aggressive ovarian cancer with a heterogeneous tumor microenvironment (TME). Advances in single-cell RNA sequencing (scRNA-seq) and spatially-resolved transcriptomics have enabled the study of complex TME. This study explores conne...

Unraveling the effects of fracture density and intensity on reservoir connectivity and flow behavior

<title>Abstract</title> Understanding the factors that influence fluid flow in fractured reservoirs is crucial for optimizing production and enhancing reservoir management. While extensive studies have focused on network characterization, the direct influence of density and inten...

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Abstract Objectives To assess and rank the effectiveness of different sexual health interventions designed to address risky sexual behaviors in PLWH. Methods We systematically searched studies published between Jan. 2010 and Dec. 2024. Randomized controlled trails (RCTs) were inc...

Unpacking the state-private nexus in China’s AI development path

The Chinese AI regulatory model has been described as state-driven, where the Chinese government seeks technological supremacy by deploying AI to entrench power through surveillance, control, and cooptation of public and private sectors. It is portrayed as a comprehensive, top-do...

Hysteresis and irreversibility in permafrost physical response to increase and decrease of CO 2 emissions

Abstract. Boreal permafrost over the Northern Hemisphere high latitudes, defined as areas where the ground temperature is below 0 °C for two or more years, stores more than twice as much carbon as the atmosphere. Therefore, thawing of the permafrost, a tipping element, due to glo...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Nutrient–Microbiota Co-Regulation of Protein Conversion in Black Soldier Fly Larvae: The Role of Alkali-Soluble Protein and Gut Microbial Communities

Insect protein farming provides sustainable advantages in land efficiency, emission reduction, and bioconversion. A major challenge is optimizing nutrient composition to achieve cost-effective protein production. This study investigates the co-regulatory mechanism between alkali-...

Building emission reduction feasibility assessment considering uncertainty

The building sector accounts for 37% of global carbon emissions, which is commonly recognized as a significant contributor to carbon emissions. The emission reduction related to the building sector has received widespread attention. Scientific calculation and assessment of buildi...

Tiny Droplets, Large Insights: Studying Peptide Aggregationwith Droplet-Based Microfluidics Hyphenated with Ion Mobility MassSpectrometry

Abstract Peptide and protein aggregation are hallmarks of numerous neurodegenerative diseases. However, the structural characterization of oligomeric intermediates remains challenging due to their low abundance, heterogenic nature, and complexity of coinciding and transient react...

Virtual coronary artery bypass grafting

<title>Abstract</title> Coronary artery bypass grafting (CABG) offers superior long-term survival over percutaneous coronary intervention (PCI) or medical therapy in patients with complex coronary artery disease (CAD). This prospective proof-of-concept study aims to develop and v...

Stage-Specific Gene Expression Profiles in Multiple Sclerosis Cortical Lesions Identified via Spatial Transcriptomics

<title>Abstract</title> Background and Objectives Multiple sclerosis (MS) is a chronic inflammatory disease characterized by demyelinating lesions in the central nervous system. While animal models have provided valuable insights into lesion development, human-based studies—parti...