Research works

Effects of human mobility on tuberculosis incidence in mainland China, 2010–2023: an ecological analysis and metapopulation modeling study

Human mobility plays an important role in the transmission of infectious diseases, yet its contribution to tuberculosis (TB) dynamics in China remains insufficiently quantified. We compiled a province-year panel for mainland China (2010–2023) to describe spatiotemporal trends usi...

Siteomix: a PyMOL plugin for the detection, alignment, and similarity analysis of protein‒ligand binding sites

The analysis of structural similarity among protein active sites is fundamental to understanding functional relationships between proteins and plays a critical role in structure-based drug design. Detailed characterization of protein‒ligand binding site similarity requires not on...

The Mechanism of Montelukast Sodium to Improve Inflammation in Ischemic Stroke: Based on Astroglia-Microglia Interactions

The present study aimed to elucidate the neuroprotective mechanism of montelukast sodium (MS) in ischemic stroke, with particular emphasis on astrocyte-microglia interactions. In vivo, adult male mice ( n = 10/group) were subjected to distal middle cerebral artery occlusion (dMCA...

The Fruits of Finitude: Reflexive Minimalism in Epistemology and Ethics

Reflexive Minimalism is a foundational paper proposing a minimal criterion for epistemic and normative stability: reflexive stability. A claim or norm is admissible only if it can survive its own application and does not undermine the conditions of reasoning, justification, or di...

Dose-dependent microbiome, metabolome and lipidome shifts in a mouse model of colitis-associated colorectal cancer using azoxymethane and dextran sodium sulphate

Colorectal cancer (CRC) remains a major health burden, underscoring the need for continued research to improve screening methods and treatment outcomes. The colitis-associated azoxymethane (AOM) and dextran sodium sulphate (DSS) mouse model has proven valuable for CRC research, a...

Research on gambling and gambling harm in Aotearoa New Zealand: a scoping review

Gambling harm is a significant public health issue made more urgent by the rapid growth of online gambling. In Aotearoa New Zealand, gambling access expanded following the introduction of gaming machines in the 1990s and is expected to expand again with the regulation of online c...

An Early Warning Algorithm for Operational Reliability of Microgrid Power Systems Based on FCM Clustering and Dubins Path Planning

Microgrid is an integrated distributed energy and load energy system, and its operation status is affected by many factors. In order to comprehensively monitor the operation status in the complex and changing microgrid environment and improve the comprehensiveness and accuracy of...

Bentall procedure in the small aortoannular complex: impact of the implantation plane on prosthesis upsizing and early outcomes—a retrospective cohort study

Proximal conduit geometry may affect prosthesis accommodation during Bentall surgery for severe aortic stenosis and a small aortoannular complex. We compared subannular-supported supra-annular conduit implantation (SSSC) with supra-annular-supported annular conduit implantation (...

SOHLH2 downregulation marks CD163-positive M2-like immunoregulatory marrow remodeling in acute myeloid leukemia: a single-center retrospective cohort study

The immunosuppressive marrow niche is a driver of acute myeloid leukemia (AML) persistence, yet transcriptional signals linked to macrophage skewing remain poorly defined. SOHLH2, a tumor-suppressive transcription factor in solid cancers, has not been characterized in AML. We inv...

Psychometric analysis of brief adolescent gambling screen, problem gambling severity index, and gambling motives questionnaire-financial among Ghanaian adolescents

The purpose of this study was to evaluate the psychometric properties of the Brief Adolescent Sport Betting Screen (BASBS), Problem Sport Betting Severity Index (PSBSI), and Sport Betting Motives Questionnaire–Financial (SBMQF) among Ghanaian adolescents. A cross-sectional survey...

Biodistricts as integrated territorial models for biodiversity conservation and climate change adaptation in the mediterranean area: evidence from lazio region (Italy)

The Mediterranean basin is one of the world’s major biodiversity hotspots and is highly vulnerable to climate change, desertification, and the simplification of agricultural systems. In this context, biodistricts have emerged as innovative territorial models integrating organic a...

Relationships between general practice residents’ level of reflection and their competencies development: results from a pilot cross-sectional study

Reflective practice is a cornerstone for developing professional competence. Despite its importance, the relationship between levels of reflection and competence remains underexplored in medical education. This association was described in trainee teachers. Along with initiating...

Beyond a one-size-fits-all prescription: shared and differential anti-inflammatory responses to exercise modalities in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a multisystem disorder in which chronic low-grade inflammation intersects with metabolic, reproductive, and psychological dysfunction, yet exercise guidance remains largely generic. This narrative review examines whether different exercise stim...

When History Becomes Geometry: On the Emergence of Processual Memory

This article develops a relational account of semantic space within the Four Chamber Model, treating space not as a pre-existing container but as an order produced by relational structure. Chamber-specific polyhedral geometries are interpreted as generative principles of lattice...

Experimental and machine learning-guided optimization of tensile strength of concrete incorporating silica fume, waste foundry sand, and polypropylene fibers

Concrete has inherently low tensile strength, which restricts the performance and durability of a concrete structure. This study investigates the effect of Silica Fume (SF), Waste Foundry Sand (WFS), and Polypropylene Fiber (PPF) on Split Tensile Strength (TS) of M40 grade concre...

Two Unpublished Tests on the End-of-Life Artificial Turf Field: Recovered Infill Sand as Concrete Fine Aggregate, and Aged Turf Crumb as Asphalt Modifier — Open Research Proposals

A full-size artificial turf field leaves roughly 120 t of silica sand and 60 t of ground tire rubber (crumb infill) when removed, against 18 t of polymer carpet. Dry mechanical separation recovers sand and rubber at 99 % purity, yet neither recovered stream has been tested in the...

Đức Hoàng Temple (Nghệ An): From Historical Memory to Heritagization and a Resource for Cultural Industry Development

This article examines the transformation of historical memory into cultural heritage at Đức Hoàng Temple, Đô Lương, Nghệ An, Vietnam, a historical-cultural relic associated with King Lê Trang Tông and the restoration of the Later Lê dynasty in the sixteenth century. The study ado...

VLA-4 integrin modulates cellular responses to sorafenib in metastasis-related processes of B16F10 melanoma cells

Metastatic progression in melanoma is driven by the coordinated activity of adhesion molecules and growth factor receptors, yet the functional interplay between integrins and VEGFR-related signaling remains poorly defined. This study investigated the role of α4β1 integrin, also k...

The therapeutic effect of genistein on microfracture based on network pharmacology, immune cell abundance analysis and experimental verification

Postmenopausal osteoporosis is a metabolic bone disease mainly attributed to estrogen deficiency. Genistein, a major phytoestrogen, has been reported to exert a direct suppressive effect on osteoclasts. The aim of this study was to explore the possible impact of genistein on oste...

Expert Perspectives on TGCT and the Outcomes of the Phase 3 MANEUVER Study of Pimicotinib Presented at ASCO and ESMO 2025: A Podcast Discussion

Tenosynovial giant cell tumor (TGCT) is a rare, locally aggressive neoplasm that significantly impacts patients’ quality of life through pain and swelling of the affected joint, resulting in limited range of motion. TGCT is categorized into two radiographic subtypes (localized an...