Research works

Tryptoline stereoprobe elaboration identifies inhibitors of the GRPEL1–HSPA9 complex

Abstract Activity-based protein profiling has identified hundreds of human proteins from diverse classes that react at cysteine residues with stereochemically defined electrophilic compounds (stereoprobes). The structure–activity relationships underlying these stereoprobe–protein...

Suppression of meiotic double-strand break formation in somatic cells by DREAM factors TCX5/6 maintains genome stability

Meiotic recombination in reproductive cells is initiated by DNA double-strand breaks (DSBs) and requires the expression of meiosis-specific genes, yet how the transcription of those genes is regulated in either meiotic or somatic cells remains unclear. Here, using a representativ...

Shame and Release Scale (SRS): A PRISMA Systematic Literature Review and Multi-Domain Psychometric Instrument Development Rationale for Indian Organisational Contexts

Background Shame is a universal emotion with profound implications for mental health, workplace functioning, and social cohesion, yet its measurement remains critically underdeveloped in South Asian organizational contexts. Despite the global burden of unmeasured shame in organiz...

A new juvenile specimen of Anhangueridae (Pterodactyloidea, Ornithocheiriformes) from the Romualdo Formation (Aptian–Albian), Northeast Brazil

Anhangueridae is the most common pterosaur group in the Araripe Basin, particularly in the Romualdo Formation. Here we describe a previously unreported specimen from the Museu de Ciências da Terra (Rio de Janeiro, Brazil), MCT.R.1491, consisting of a partial lower jaw associated...

Infant hippocampal and amygdala volume in an observational follow-up from a randomized clinical trial for maternal prenatal depression

Abstract Prenatal maternal depression may have intergenerational effects on offspring brain development, with potential socioemotional consequences. This observational follow-up study examines brain development and subsequent negative emotionality among 109 infants born to mother...

Calm Versus Its Look-Alikes: A Glossary of Eight Words That Are Easy to Confuse

Eight calm-and-power words paired with their look-alikes, from composure to restraint, offered as background reading for The Billionaire Calm Power. Educational background article; study and reflection only.

Beyond intramuscular nerve blockade: a complementary perspective on the anatomic basis of the PENG block

We read with great interest the study by Gautier and colleagues, which used a multimodal approach combining gross dissection, cryo-cross-sectional analysis, and histology to characterize injectate distribution following the pericapsular nerve group (PENG) block.[1][1] The methodo...

Chain of Epistemic Custody: Nothing Crosses Between AI Agents Without Lineage

AI agents now pass claims to one another and act on them: they research, plan, buy, file and pay. This creates three gaps. An estimate produced by one agent can reach another as a fact, because nothing that travels with it records what it was. An agent can act on grounds that no...

Joint Psychometric Validation of the Shame and Release Scale (SRS) and the Fundamental Peace Scale (FP20) in Indian Organisational Contexts: A Pre-Registered Validation Protocol

Background The Shame and Release Scale (SRS) and the Fundamental Peace Scale (FP20) address a critical measurement gap in South Asian organisational contexts: the absence of validated instruments that simultaneously assess shame burden and fundamental wellbeing. The SRS is a 40-i...

Transfer dynamics and spectral cascades in graph-coupled Kuramoto networks

Abstract This work introduces a spectral transfer formalism for nonlinear synchronisation dynamics to resolve how internal dynamical activity redistributes across network scales, moving beyond traditional global observables like the Kuramoto order parameter. By projecting Kuramot...

Sequential Dual Catalysis Merging Enantioselective Cu-Catalyzed Conjugate Addition with Intramolecular Pd/Ir-Catalyzed Allylic Alkylation

The combination of asymmetric conjugate addition and allylic alkylation has emerged as a powerful strategy for the stereocontrolled construction of complex molecules. However, such transformations have been largely limited to intermolecular processes and have not been explored on...

Reactivity of Alkali Metal Yldiides Toward Carbon Disulfide

The use of carbon disulfide as CS source for the construction of sulfur-containing molecules is an attractive strategy in organic synthesis. Herein, we report the formation of CS2 adducts with α-metalated ylides. The resulting alkali metal salts are readily isolable and were char...

Spin Manifolds in the [Fe4S4(SCH3)4]2– Cluster from Localized Active Space State Interaction Singles and Pair-Density Functional Theory

Abstract Iron–sulfur clusters play central roles in biological photosynthesis, respiration, and catalysis. The [Fe4S4(SCH3)4]2– cluster possesses a dense manifold of low-lying electronic states arising from strong magnetic interactions among the Fe centers, making its electronic...

Redox Buffering and Corrosion in Molten Chloride Salts Dictated by Chlorobasicity

Abstract This study establishes an in situ synchrotron approach to directly link molten-salt chemistry, redox-buffer speciation, and alloy corrosion in chloride melts. Using a first-of-its-kind corrosion cell coupled to simultaneous X-ray absorption spectroscopy (XAS) and X-ray f...

Transmission‐Mode Silicon‐Rich Nitride Mie‐Void Metasurfaces in the Visible

ABSTRACT Mie‐void metasurfaces have so far been developed mainly in reflection, where subwavelength voids embedded in high‐index media support localized resonances and spectrally selective optical responses. Here we introduce Mie‐void metasurfaces operating in transmission, imple...

Review article: Mountain flash floods: from hazard formation to disaster risk reduction pathways

Abstract. Flash floods in mountainous regions are becoming more frequent and destructive under climate warming, yet cross-regional understanding of their triggering mechanisms, cascading impacts, and governance remains fragmented. This review synthesises 1,967 studies published d...

‘People need to be a bit more understanding that my body is wrecked’: A qualitative exploration of inpatient hospital care for people living with multiple long-term conditions

BACKGROUND: Living with multiple long-term conditions (MLTC) is becoming increasingly common with far-reaching consequences for individuals and healthcare systems. People with MLTC often face complex care pathways through health systems - especially hospitals, which are largely c...

Front-line decision-making: a thematic analysis of interviews with hospital staff on referrals, admissions, and care for people with multiple long-term conditions

BACKGROUND: Multiple long-term conditions (MLTC) are increasingly common and present challenges for hospital healthcare professionals (HCPs) making decisions about admissions, referrals, and care management in the context of a single-organ oriented health system. This qualitative...

Nonhomogeneous elastic turbulence in the two-dimensional Taylor-Couette flow

Elastic turbulence is a spatially and temporally disordered flow state appearing in viscoelastic fluids at vanishing fluid inertia and large elasticity. The resulting flows have broad technological interest, particularly to enhance mixing and heat transfer in microdevices. Althou...

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

Post-traumatic stress disorder (PTSD) is a mental health disorder triggered by exposure to a traumatic event, which manifests with anguish, intrusive memories, and negative mood changes. So far, there is no efficient treatment for PTSD other than symptomatic palliative care. Howe...