Research works

The Mount Wilson Paradigm: Restoring the Eternal Universe via the Temporal Equivalence Principle

Cosmological redshift is standardly interpreted as a geometric signature of spatial expansion. This interpretation requires a fundamental assumption that is defined herein as the Isochrony Axiom: the premise that, after gravitational and kinematic effects derived from the spaceti...

The Symbiocene as a transformative vision

Abstract We live in times of crises and calls for a transformative social‐ecological change are voiced increasingly often. The question is, however, how such a transformation could be achieved. The prevailing view is that we are living in an era in which human activities signific...

EuroMillions Breakthrough Mining — 1829 Sources, 13806 Leads Extracted — E8 Intelligence Research

Mined 1829 lottery+quantum breakthroughs. Extracted 13806 leads across 13 categories. 11799 high-value leads found. Categories: {"CORRIDOR": 1153, "FORMULA": 995, "GEOMETRIC": 727, "FORWARD_ATTEMPT": 1206, "QUANTUM": 1421, "TIMING": 208, "CELESTIAL": 1081, "GEMATRIA": 1152, "CONS...

Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice

Trained immunity enables innate immune cells to acquire memory-like responses, offering a strategy to enhance antitumor immunity. However, the metabolic‒epigenetic mechanisms underlying this process remain poorly defined. Here, we show that lipopolysaccharide-induced macrophage t...

Depletion of davemaoite in Earth’s ambient lower mantle

Abstract The mineralogy of the Earth’s lower mantle is fundamental to understanding the planet’s formation, composition, evolution, and dynamics. However, uncertainties in the elastic properties and phase transitions of CaSiO₃ davemaoite—the third most abundant phase in a pyrolit...

SYNTHESIS AND IN-SILICO ASSESSMENT OF CHALCONE DERIVATIVES AGAINST BACILLUS SUBTILIS

Chalcones are privileged flavonoid scaffolds with a broad spectrum of antimicrobial activity. In this study, a series of brominated chalcone derivatives (103, 116, 198 and 200) were synthesized by Claisen–Schmidt condensation followed by regioselective bromination using tetrabuty...

pCORE, a set of open modular plasmids compatible with golden gate assembly

Abstract Modular DNA assembly based Golden Gate cloning (MoClo) is a widely used framework to assemble genetic constructs. A number of MoClo “destination vectors” have been developed, however, available options are still limited with regards to copy number and antibiotic resistan...

Resonant Torsion Indexing of E8 Anti-Commutative Blocks — E8 Intelligence Research

We introduce a topological indexing schema that assigns integer torsion signatures to successive root vector transitions in the phi‑coupled E8 root lattice. By correlating these signatures with anti‑commutative pair activity, the schema predicts high‑probability resonance cluster...

Distributed Ledger Technology Adoption and Market Sustainability in an Emerging Capital Market: Evidence from Nigeria

Distributed Ledger Technology (DLT) has emerged as a transformative component of blockchain architecture with the potential to modernize capital market infrastructure through enhanced transparency, security and operational efficiency. Despite increasing global adoption of DLT in...

Does imaging-based clinical staging improve the predictive performance of the CAPRA score?

Biochemical recurrence (BCR) after radical prostatectomy (RP) remains a major clinical challenge, necessitating accurate preoperative risk stratification. We evaluated whether replacing digital rectal examination (DRE)-based staging with imaging-based staging improves the predict...

Lunar-Tectonic Interaction in a Spatial Seismic Simulator: Statistical and Physical Validation with Real Catalogs

We present the ECG V2.1 simulator, a hybrid geophysical model that integrates tectonic loading, lunar tidal modulation, and a dynamic astronomical threshold to generate seismic ruptures on a spatial grid. The model incorporates a physically consistent rupture module based on stre...

Dual Burden of Community Violence and Policing in A Large Urban City

Abstract Marginalized urban communities are affected by both high levels of violence and pervasive police presence. This qualitative study examined the dual burden of violence and over-policing, which contributes to hypervigilance and stress among community members. To explore th...

Neuro-Ocular Destabilizing Ideology Detection: A Real-Time Physiological Measurement System for DIS/HESS Activation via Pupillometry and Eye-Tracking

NODID — Neuro-Ocular Destabilizing Ideology Detection — is a non-invasive ocular monitoring system that detects destabilization of the mind through the eyes in real time. Clinical problem: Patients report visual fog, strain, instability under stress that does not map to OCT/field...

Projective Persistence and the Physical Sub-Spectrum: A Dynamical Selection Criterion for the Capacity Exponent

The O12–O19 sequence establishes that the physically relevant observable on $\mathrm{Heis}_3(\mathbb{Z}/q\mathbb{Z})$ is the canonical pair-level quantity $\sigma_{\mathrm{pair}}^{\mathrm{can}}(n)$, with capacity exponent $\delta_{\mathrm{pair}} \approx 7.44$ consistent with the...

Commitment, Not Sequence: A Formal Model of Error Foreclosure in AI-Mediated Learning

We propose and formalize a specific cognitive mechanism — error foreclosure — for how generative AI reshapes learning, and distinguish it sharply from cognitive offloading. Offloading concerns processes relocated to an external store (memory, calculation); error foreclosure conce...

Higher protein intake preserves lean soft tissue and promotes lipid mobilization during a 7-day very-low-calorie diet

Abstract Severe energy restriction often results in the loss of lean soft tissue (LST) in addition to fat mass. This randomized controlled trial examined the effects of differing protein energy densities on body composition and metabolic responses during a short-term, very-low-ca...

Building a Stack for Systems Deployment

We are introducing few lines of methodology to start building Models & Systems for Deployment. We start first with Asana Platform and the Automated Fact-Checker [here]. More Collaboration Invitation will be sent to participate in the project.

AlphaFold Hemoglobin Exercise

<p>AlphaFold has fundamentally transformed biological science by enabling accurate prediction of protein structures and protein-ligand interactions. In this activity students compare the structures of native and mutant hemoglobin structures to discuss its impact on their fu...

Animistic Solutions to Semiotic Disputes

Description Animistic Solutions to Semiotic Disputes is a speculative philosophical essay examining whether the analytical distinctions made between different kinds of signs may obscure a more fundamental continuity between things and their representations. Beginning with the pos...

Biological and metabolism responses of earthworm (Eisenia fetida) exposed to metribuzin

Metribuzin, a widely used triazine herbicide, has been extensively studied for its toxic effects on aquatic organisms, but its impact on soil organisms, particularly earthworms, remains insufficiently understood. This study investigates the ecological toxicity of metribuzin on Ei...