Research works

Structural and Biophysical Characterization of C‐Glycosylic 1,2‐Thiodisaccharides Reveals Determinants of Selective Binding to Galectin‐7 and Galectin‐8N

Achieving isoform selectivity within the galectin family remains a central challenge in glycomimetic drug design due to the highly conserved architecture of their carbohydrate recognition domains. Here, we define the structural and thermodynamic basis of recognition of a series o...

The Holographic Arrow of Time: Objective Wavefunction Collapse and Topologically Filtered Baryogenesis via Modular Projection

This paper explores the thermodynamic consequences of a bounded, non-Lipschitz primordial expansion. By abandoning the infinite-entropy initial singularity, we demonstrate that the non-equilibrium geometric expansion of the early cosmos natively generates the cosmological Arrow o...

Demonstration of Proton Conduction in Electrolyte‐Supported Cesium Borophosphate Membrane Electrode Assemblies

Electrolyte‐supported membrane electrode assemblies (MEAs) were fabricated using Cs 3 H 2 [BOB(PO 4 ) 3 ] (affectionately dubbed CsBOB) as the electrolyte and membrane separator and tested for proton conduction and power generation at temperatures up to 250 °C. The devices reache...

Empirical Disqualification of the ZPIF Model and its Variant forms: Multi-Domain Sequential Stress-Tests vs. the SRA-AM Regulator (2023–2026)

The author applies a rigorous empirical audit to contrast the Scale-Regulated Aggregation (SRA) framework against standalone unregulated quadratic models, identified here as the Zero Pair Interaction Functional (ZPIF) Parasite Model and all its variants and variant forms. [7][8][...

LOW-RESISTANCE TRAINING AS A CATALYST FOR ENHANCING MUSCULAR ENDURANCE IN YOUNG-OLDER MALE ADULTS: IMPLICATIONS FOR ACTIVE AGEING.

This study assessed the effect of low-resistance training on muscular endurance of young-older male adults in Samaru, Zaria, Nigeria, particularly in the context of promoting active ageing through lifelong physical activity. A repeated-measures experimental research design was us...

CD36-mediated lipid-accumulation in reactive microglia contributes to retinal degeneration via the NLRP3-IL-1β pathway in mice

Microglia are central regulators of retinal immune homeostasis, yet their pathogenic states in retinal degeneration remain less well understood. Here we identified a distinct subset of lipid-accumulated reactive microglia (aLARM), using scRNA sequencing and spatial transcriptomic...

Health and nutrition returns to clean cooking fuel access across the rural-urban divide

Access to clean cooking fuels is central to advancing health, equity, and environmental sustainability worldwide. However, despite sustained policy efforts, a substantial share of households, especially in developing countries, still rely on polluting fuels, with adverse effects...

Modular Forms, E8 Lattice Theta Functions, and Interpolated Critical L-Values — E8 Intelligence Research

FINDING: Modular forms count points on E8 lattice via theta functions, linking number theory, complex analysis, and Langlands program; new interpolated sequences connect to critical L-values. MATH: - E8 lattice theta function: \(\Theta_{E8}(\tau) = \sum_{x \in E8} q^{x \cdot x} =...

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

ABSTRACT Sexual fate in vertebrates is generally considered developmentally fixed; however, teleost fishes exhibit remarkable flexibility in their reproductive systems. It remains unclear whether a fully differentiated gonochoristic vertebrate can undergo complete and functional...

Chemomechanically Adaptive MXene–Si–Ag Dual‐Seed Interlayer Enabling Low‐Pressure Sulfide all‐Solid‐State Batteries

ABSTRACT Sulfide‐based all‐solid‐state batteries (ASSBs) promise high safety and energy density; however, sustaining stable operation under low stack pressure remains challenging due to chemo‐mechanical instability at solid‐solid interfaces. Here, we report a chemomechanically ad...

Review of Autism Spectrum Disorder Treatments: Conventional and Ayurvedic Approaches

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by daily challenges associated with social communication, repetitive motions and behaviors, and restricted interests. While cases are rising around the world, many families and healthcare providers have...

PHYTOCHEMICAL CHARACTERIZATION, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF CALLISTEMON CITRINUS LEAF EXTRACT

Callistemon citrinus is a medicinal plant rich in bioactive phytochemicals; however, comprehensive studies integrating physicochemical standardization, phytochemical characterization, antioxidant evaluation, and antimicrobial activity of its hydroalcoholic leaf extract remain lim...

On the necessity of an alternative conception of liberal moral education in the Global North

This paper describes and defends an account of a liberal philosopher of education in response to the current political, social justice and ecological crises that are prevalent in many countries in the Global North and that are attributed to the dominance of (neo)liberalism. It be...

EuroMillions Breakthrough Mining — 1830 Sources, 13817 Leads Extracted — E8 Intelligence Research

Mined 1830 lottery+quantum breakthroughs. Extracted 13817 leads across 13 categories. 11810 high-value leads found. Categories: {"CORRIDOR": 1154, "FORMULA": 996, "GEOMETRIC": 727, "FORWARD_ATTEMPT": 1207, "QUANTUM": 1422, "TIMING": 208, "CELESTIAL": 1082, "GEMATRIA": 1153, "CONS...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

Decision Custody: Who Answers for a Decision After the Machine That Made It Is Gone

If someone challenges an AI-made decision three years from now, could your organisation still show how it was made? For most, the honest answer is no. Models are replaced within a year or two, suppliers change hands, reference data is overwritten — while the decision itself lives...

Holographic Information Ontological Framework • The Brain — Companion Paper: The Writing Discipline of Ontological Language

Holographic Information Ontological Framework: The Brain (HIOFtB) This is a four-paper series plus a short companion note. It is written for readers in neuroscience, consciousness studies, algebraic topology, and the philosophy of mind -- not as a finished theory, and not only fo...

More than Infrastructure: How Institutional Frameworks Shape Socioeconomic Value in Toll Roads

Abstract Toll road projects are employed in developing countries to deliver critical infrastructure, fostering socioeconomic development. However, these initiatives often face community opposition because of misalignment between perceived local needs and promised benefits. This s...

The Bridge Certificate Applied to the Joshi ATS Series: A Ledger Audit (DRAFT)

DRAFT / work in progress. This is a versioned working paper of an ongoing research programme; newer versions supersede older ones. No claim about the truth of the abc conjecture, the correctness of IUT, or the correctness of the ATS series is made. We audit Kirti Joshi's Arithmet...

Electroweak Coupling Constants and the Koide Relation

Dimensionless constants occupy a special place in fundamental physics because their numerical values do not depend on the choice of units. This paper investigates an idealized geometric construction linking the Koide relation for charged leptons to the gauge couplings of the elec...