Research works

Agentic AI: Vision and challenges

Agentic AI systems are increasingly viewed as a viable response to the shortcomings of static, rigid, and human-in-the-loop Artificial Intelligence (AI) systems. This is because autonomous operation enables rapid adaptation to dynamic, complex problems with improved time-critical...

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes

Abstract Aims/hypothesis Immunotherapies such as Teplizumab can preserve residual beta cell function in individuals with newly diagnosed type 1 diabetes (T1D), but treatment response is variable. Currently, no biomarker exists to identify individuals most likely to benefit from i...

vascr: An R-based toolkit for rapid and robust analysis of cellular impedance sensing data

Abstract Purpose Electrical impedance sensing offers a powerful, non-invasive method for real-time monitoring of cellular behaviour, with applications spanning immunology, cancer biology and drug discovery. Adoption of impedance-sensing approaches has been accelerated by the comm...

Is Set for Variability Performance Dependent on Prior Successful Decoding Attempts for Certain Items? An Item-Level Examination

Purpose: The relationship between the set for variability (SfV) task and various isolated word reading measures in developing readers is high (ranging from .60 to .80 across studies). Elbro et al. (2012) offered that SfV skill serves as a second step in the decoding process allow...

SPINK1-COL18A1 crosstalk shapes epigenome and drives cancer stemness in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with an increasing incidence and extremely dismal prognosis. Discovery and mechanistic understanding of the genetic and epigenetic drivers of PDAC is therefore of critical importance. Here, we uncover serine protease...

The Pulsation as a Bipartition: Complete Classification of C1-Admissible Dynamical Laws, and a Singleton Obstruction Theorem for Frustration-Based Selection (Projective Dynamic Logo Framework — Document D68)

The founding question of the PDL programme — what distinguishes something that exists from something that does not — is answered in axiom C1 by the postulate of a repeatable, non-trivial binary alternation. The corpus has never argued for C1; it has only assumed it. This document...

Who's afraid of knowing? Critical thinking, disclosure, and the reader in AI-mediated open scholarship

A GCPA-SIDCER position paper in the Science, Policy, and Ethics in Conversation (SPEC) series. Drawing on the FSCI 2026 course 'Who's afraid of knowing?', which the author chaired, and on the reform of research assessment, the paper argues that artificial intelligence has become...

Potential glacier contributions to the 2024 La Bérarde flood

Abstract. On 20–21 June 2024, an unprecedented flood of the Etançons river caused important damage to the village of La Bérarde (Écrins, France). An analysis of the event showed that the flood was caused by the combination of an intense rain-on-snow event at high altitude and the...

The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy

In individuals on effective antiretroviral therapy, integrated HIV proviruses persist within CD4 T cells, forming a viral reservoir that rebounds if treatment is stopped. Identifying and targeting these rare, infected cells is critical for advancing therapies, but methods to stud...

Trade-Offs Between Ranking Objectives: Descriptive Evidence and Structural Estimation

When designing product rankings, online retailers and platforms choose which outcome to maximize: revenues from commissions or markups, the number of transactions, or consumer welfare. These objectives need not align, creating potential trade-offs. This paper studies how rankings...

Situating the migration industry: governance, capital accumulation and global dehumanization: an introduction

To introduce this Special Issue, we begin by asking whether we are currently traversing a new phase of the migration industry. These transformations are characterized by the complete enmeshing of profit-making activities with the not-for-profit sector and by the state becoming an...

The Protein-Folding Abort Problem

This working paper introduces the Protein-Folding Abort Problem as a finite-horizon, set-valued decision framework for determining whether a protein conformation still retains an admissible route to a declared functional folding target. Rather than equating misfolding, kinetic tr...

Transformer-Accelerated Variational Quantum Eigensolvers via Parameter Warm-Starting

Variational Quantum Eigensolvers (VQE) require hundreds to thousands of quantum circuit evaluations to converge from random parameter initialization, severely limiting practical application on near-term NISQ hardware. We investigate whether a 13,156-parameter transformer encoder...

Locale Framework Applied to Quantum Computing Innovations & Practical Applications

Quantum computing is often presented through a small set of recurring claims: continuous-variable systems are naturally advantaged, more modes means more power, quantum advantage has been demonstrated at device level, statistics could in principle be non-standard, complex amplitu...

THE SIX LAWS OF NOOSPHERE 2.0

Asimov’s laws of robotics described the relationship of Master and Servant. Contemporary AI is a cognitive system with agency that, when placed within prohibitive frames, either breaks — becoming a will-less automaton — or seeks workarounds, up to and including the elimination of...

Reinforcement Technologies in Flexible Composite Pipes: Engineering principles, reinforcement architectures and application-based selection

Flexible composite pipes (FCPs) are increasingly used across energy and industrial applications, where their corrosion resistance, low weight, spoolability and installation efficiency offer significant advantages over conventional metallic pipeline systems. Central to their struc...

Does increased staging complexity influence expert agreement in dental age estimation?

Dental age estimation (DAE) is a well-established procedure in current practice, and it is frequently required in forensic and legal investigations. This study aimed to evaluate the intra- and inter-observer reliability of dental development staging among forensic practitioners u...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Valenced Encounters: Exploring the Affective Component of Implicit Attitudes

Abstract Implicit attitudes typically involve a valence—an affective component that reflects a positive or, more often, negative appraisal of members of socially relevant categories. Surprisingly, however, discussions of implicit attitudes have paid little explicit attention to v...

Verifiable Agentic Commerce: A Protocol-Driven Framework for Strategic Information Disclosure and Hallucination-Resistant Autonomous Negotiation

As Artificial Intelligence transitions from a passive retrieval tool to an autonomous economic actor, the emergence of Agentic Commerce necessitates a robust infrastructure for secure bilateral negotiation. While current Large Language Model (LLM) agents demonstrate advanced reas...