Research works

Dual Anchors: China-U.S. Factors Jointly Determining Global Gold and Crude Oil Pricing—Systematic Evidence Based on Exhaustive Testing with VIF Constraints

Traditional commodity pricing literature has long anchored gold and crude oil pricing to U.S.-centric variables, leaving China-linked factors systematically excluded from quantifiable pricing frameworks. This study employs a rolling regression framework with a 756-trading-day win...

Interest Rates Without an Anchor: Multi-Window Percentiles, Exhaustive Testing, and the Pricing Logic of the China-U.S. Yield Spread—On the Dual-Anchor Regime and Institutional Interface Theory of Global Asset Pricing

How to determine whether a sovereign bond is “fairly valued” remains an unresolved question in fixed income research. Traditional term structure models focus on the dynamics of yields but do not address where current yields stand in their own history. This paper proposes a valuat...

INDIVIDUAL VARIATION IN INFANT SPEECH PROCESSING: IMPLICATIONS FOR LANGUAGE ACQUISITION THEORIES

To what extent does language acquisition recruit domain-general processing mechanisms? In this dissertation, evidence concerning this question is garnered from the study of individual differences in infant speech perception and their predictive value with respect to language deve...

Co-primeness preserving higher dimensional extension of $q$-discrete Painlevé I, II equations

We construct the $q$-discrete Painlevé I and II equations and their higher order analogues by virtue of periodic cluster algebras. Using particular $k \times k$ exchange matrices, we show that the cluster algebras corresponding to $k=4$ and $5$ give the $q$-discrete Painlevé I an...

Loss of M1 acetylcholine receptor-mediated orexinergic activity contributes to immune dysfunction in experimental sepsis

<title>Abstract</title> <italic>Background</italic>: Sepsis (life-threatening organ dysfunction caused by a dysregulated host response to infection) causes millions of deaths worldwide annually. Sepsis-induced changes in brain regulatory functions remain understudied. Previous wo...

Integrating research and educational practice: perspectives from directors of educational intervention companies

Enthusiasm for an evidence-informed approach towards educational interventions is currently hindered by difficulties integrating research findings into practice. To develop an understanding of current challenges for evidence integration, this qualitative study examined how commer...

The impact of simulation with debriefing on developing clinical competence and performance in paramedicine students

<title>Abstract</title> Introduction Paramedics handle diverse medical and trauma cases, where any lapse in competency can compromise patient safety. Student paramedics must meet high standards set by oversight bodies to protect both the profession and the public. Growing evidenc...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...

Practices of community pharmacists towards COVID-19 treatment in Vietnam: a simulated client study

<title>Abstract</title> Background Recent reports have raised concerns about drug overuse and misuse in self-medication practices for COVID-19 treatment. This study was aimed to assess the availability and appropriateness of medication dispensing provided by community pharmacists...

PPAD-Membership for Problems With Exact Rational Solutions: A General Approach via Convex Optimization

Abstract. We introduce a general technique for proving membership of search problems with exact rational solutions in PPAD, one of the most well-known classes containing total search problems with polynomial-time verifiable solutions. In particular, we construct a “pseudogate,” c...

Unmasking conversational bias in AI multiagent systems

Detecting biases in the outputs produced by generative models is essential to reduce the potential risks associated with their application in critical settings. However, the majority of existing methodologies for identifying biases in generated text consider the models in isolati...

“Prison is routine”: Narrating release and reintegration in settler colonial Canada

This article examines how long-term prisoners in Western Canada narrate their anticipated re-entry to a settler-colonial society using a narrative approach to analyze 147 interviews with federally incarcerated people. The great majority of our participants describe experiencing c...

The effects of CO2-rock interaction on the failure mode of clay-rich sandstone

Understanding how rock formations respond to CO₂ injection is critical for geological carbon storage. This study examines the impact of CO₂-rock interaction on the failure mode of clay-rich Tuscaloosa sandstone. To simulate CO₂-rock interaction in the subsurface, we conducted CO...

Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses

Abstract Background Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemod...

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137

ABSTRACT Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by ph...

Unveiling the cooling effects of urban green spaces in Eastern China: spatial heterogeneity, diurnal asymmetry, and nonlinear margins of 2D/3D features

Urban green spaces (UGS) play an important role in mitigating urban heat island effects. However, the mechanisms underlying their cooling effects are still not fully understood, particularly regarding the role of three-dimensional vegetation structure and nonlinear threshold resp...

Bidirectional AllostericLigand Regulation in a CentralGlycolytic Enzyme

Abstract Allosteric regulation enables fine-tuned control of enzyme activity in response to cellular signals, yet its molecular basis often remains unclear. Phosphofructokinase-1 (PFK), the highly conserved, rate-limiting glycolytic enzyme, is a paradigm for Monod–Wyman–Changeux...

Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease

Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...

Saturable absorption in NV-doped diamond studied by femtosecond Z-scan

Nonlinear optical absorption in commercially available diamond crystals containing nitrogen-vacancy (NV) centers is investigated using femtosecond open-aperture Z-scan measurements at a wavelength of 1032 nm. Experiments were performed on a high-purity electronic-grade diamond an...