Research works

P1.106. Proteomic Signatures of Chemoresistance in Oesophageal Adenocarcinoma Cell Models

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Oesophageal adenocarcinoma is a rapidly rising cancer with poor prognosis. Despite advances in surgery, chemotherapy, and targeted therapy, five-year survival remains below 20%. Treatment failure is largely...

P1.227. A Composite Body Composition Score Independently Predicts Long-Term Survival After Esophagectomy for Cancer

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – long term outcomes Background Body composition (BC) measures are established determinants of esophageal cancer outcomes. Beyond known survival predictors such as cancer stage and performance status, a com...

Effects of cephalexin treatment on DNA replication dynamics in Escherichia coli

Abstract Background In bacteria, DNA replication and chromosome segregation are tightly coordinated with cell division. The replication run-out method, which combines inhibition of transcription initiation by rifampicin with inhibition of cell division by cephalexin, is widely us...

The Mechanism That Allows Reality: The First Act, Emergent I, and Digital Control Act

Human author, creator, and model source: Joe Rattanong. Speaking narrator: DCA reconstructing Joe Rattanong's retained model. This record is the complete current whitepaper whole. It contains the English explanatory whitepaper, the typed mathematical companion, public-draft langu...

Determinants of mutation susceptibility along the genome are largely invariant across human tissues

Abstract Background The propensity for accumulating somatic mutations varies along the genome, which critically influences somatic mosaicism, tumor evolution and the potential role of somatic mutations in the context of age-associated diseases. Genomic factors contributing to the...

Transforming medical ethics education: a scoping review of experiential, digital, and AI-integrated pedagogies

Medical ethics education plays a central role in preparing health professionals for complex clinical decision-making. However, rapid technological advances, evolving healthcare systems, and increasingly intricate ethical dilemmas have highlighted potential limitations of relying...

Optimization Method for Area Controller Scheduling Integrating Efficiency, Fatigue and Fairness

Abstract To address the problem that existing scheduling methods for area air traffic controllers cannot effectively coordinate and optimize operational efficiency, fatigue risk, and working time fairness, this paper proposes a collaborative optimization method based on the multi...

RydbergPhaseDepthQA: A Finite-Size Hardware Witness of a Multi-Controlled-Phase Depth-Hierarchy Mechanism on IonQ Forte-1

RydbergPhaseDepthQA investigates whether a finite-size witness of the recently established quantum circuit-depth hierarchy mechanism remains experimentally distinguishable after provider compilation and noisy execution on a real quantum processor. The experiment compares a frozen...

Terrestrial environmental DNA survey substantially improves detection of satellite populations for an invasive insect

Abstract Early detection of satellite populations is essential for managing invasive species, but traditional methods often fall short when populations are sparse and widespread. We assessed the effectiveness of terrestrial environmental DNA (eDNA) surveys for detecting spotted l...

Genomic epidemiological investigation and effectiveness of multidisciplinary interventions in a multidrug-resistant Acinetobacter baumannii outbreak in a university hospital intensive care unit: A retrospective study

A sudden surge in multidrug-resistant Acinetobacter baumannii (MRAB) incidence in a medical-surgical intensive care unit (ICU) in Seoul, Republic of Korea, in December 2023 prompted a molecular epidemiological investigation and the implementation of multimodal infection control i...

Stereotypical interciliary contacts in a C. elegans sense organ

Physical interactions among cells and their processes are critical for intercellular communication and the generation of ordered tissue patterns. Primary cilia projecting from the cell surface have recently been shown to form contacts with the processes of diverse cell types, as...

A Composite Index Framework for Quantifying External Influences on Built Environment Planning and Decision Making

Abstract Infrastructure systems are influenced by a wide range of external factors, including demographic changes, economic cycles, environmental stressors, and technological transitions. These factors affect infrastructure demand, operating conditions, and deterioration processe...

Characterizing tree species richness in Indigenous Peoples’ lands: addressing often-overlooked data limitations and biases

Abstract Several studies have characterized species richness distribution in Indigenous Peoples’ Lands (IPL) using global biodiversity datasets. However, these datasets contain substantial limitations and biases which may compromise the accuracy of spatial biodiversity assessment...

Benchmarking generative AI tools for literature retrieval and summarization in genomic variant interpretation

Abstract Background Generative AI is increasingly used to extract structured information across domains, but its reliability in academic and clinical research, where precision and accuracy are essential, remains largely unexplored. This study evaluates the ability of Large Langua...

Multisoliton Solutions and Blow Up for the $$L^2$$-Critical Hartree Equation

Abstract We construct multisoliton solutions for the $$L^2$$ L 2 -critical Hartree equation with trajectories asymptotically obeying a many-body law for an inverse square potential. More precisely, we consider the m -body hyperbolic and parabolic non-trapped dynamics. The pseudo-...

Data-driven construction of an imine reductase library capable of broad-scope reductive amination at equimolar substrate concentrations

Reductive amination catalysed by imine reductases and reductive aminases has emerged as a powerful method for the asymmetric synthesis of chiral amines, yet the generality and practical limitations of these enzymes remain poorly understood. Here, we combine large-scale, iterative...

Patterns of information flow in autism canonical brain network by transfer entropy approach

Abstract The functional brain activity network is the result of the harmonious activity of different regions. Each harmonic activity requires feedback from different areas of activity to adjust itself. As a result, any disorder in this harmony can affect the functional brain acti...

Preprint of "A Laterally Conductive Mesh Interphase Enables Spatially Extended Zinc Deposition for Aqueous Zinc Batteries"

Zn metal anodes often fail because interfacial reactions become increasingly localized during cycling, leading to uneven deposition and dendrite growth. Existing artificial interphases can mitigate side reactions or regulate nucleation, but they rarely regulate the interfacial el...

Preprint of "A Laterally Conductive Mesh Interphase Enables Spatially Extended Zinc Deposition for Aqueous Zinc Batteries"

Zn metal anodes often fail because interfacial reactions become increasingly localized during cycling, leading to uneven deposition and dendrite growth. Existing artificial interphases can mitigate side reactions or regulate nucleation, but they rarely regulate the interfacial el...

A Scoping Review of Climate Change Impacts and Adaptation in South Sudan (2021–2026): Gendered Dimensions in Juba, Western Equatoria, Jonglei, and Eastern Equatoria

This scoping review provides a systematic mapping of the literature concerning the gendered dimensions of climate change impacts and adaptation in South Sudan. It addresses a critical gap in synthesising how climate-induced environmental changes, particularly those affecting natu...