Research works

Integrated proteomic and metabolomic analysis identifies complement activation and metabolic alterations in the serum of patients with idiopathic membranous nephropathy: an exploratory study

Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults, yet its pathogenesis remains incompletely understood. This exploratory study aimed to characterize serum molecular profiles in IMN patients by integrating proteomics and metabolomics analys...

Arithmetic Renormalization Dynamics for the Syracuse Map: Exact Valuation Cylinders, 3-Adic Transport, and Max-Plus Packet Certificates

This Version 2.0 develops an arithmetic-renormalization and operator framework for the accelerated Syracuse map while keeping three logically distinct levels of the Collatz problem separate: exact finite arithmetic, averaged transport, and worst-branch deterministic obstruction....

Isolation as a Mechanism of Control: Migrant Workers, Forced Labor, and Well-Being in Malaysia’s Textile Sector

This study examines isolation, identified by the International Labour Organization as an indicator of forced labor, as a structural mechanism of control shaping the well-being of migrant workers in Malaysia’s textile manufacturing sector. Isolation is conceptualized as a multidim...

Technical Corrections and Missing Justifications in a Streamlined Proof of the Three-Dimensional Kakeya Set Conjecture

This technical note examines version 1 of Guth, Wang and Zahl, A streamlined proof of the Kakeya set conjecture in R^3 (arXiv:2601.14411v1). It records parameter and bookkeeping defects in Theorem 7.3(B), supplies a self-contained proof of the omitted shaded slab estimate in Lemm...

EXTRACTED METHOD: azimuth_alignment_check — E8 Intelligence Research

rule: Given a cache location and central pillar pair, compute azimuth; if azimuth modulo 30° or 45° is within 0.5°, flag as PPNA solar/lunar alignment. source: rlab #185 Author: Andrew Stewart Caldin, Independent Researcher, UK. Part of the E8 Intelligence Research series. Platfo...

Hierarchical grouped convolution and multi-scale vision transformer for uncertainty-aware early breast cancer detection using mammography

Abstract Early breast cancer detection using mammography remains challenging because existing deep learning methods often emphasize either local lesion characteristics or global contextual information, while providing limited uncertainty quantification and clinically reliable pre...

Prediction-Horizon Transport of Adam's Optimal Momentum State

Adam's future behavior depends not only on the model parameters but also on its hidden first-moment state. This work develops a prediction-horizon transport theory for Adam's finite-horizon optimal momentum state under frozen local quadratic dynamics in a prescribed correction su...

Efficacy, safety, and pharmacokinetics of pumecitinib nasal spray for moderate-to-severe seasonal allergic rhinitis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial

Background Seasonal allergic rhinitis (SAR) is a pollen-triggered condition causing nasal inflammation and quality of life impairment. Pumecitinib, a topical Janus kinase (JAK) inhibitor may modulate allergic inflammation. We evaluated the efficacy, safety, and pharmacokinetics o...

Institutional Investor Impact Across Asset Classes: Exit, Voice, and/or Denial of Unconditional (Re)financing

ABSTRACT Research Question/Issue The Voice versus Exit debate among institutional investors dissatisfied with corporate issuers remains narrowly framed: Academic inquiry is de facto limited to listed equities. This overlooks the role of governance in corporate financing, which du...

MENKUL KIYMETLER PİYASASINDA İŞLEM BAZLI MANİPÜLASYONLARIN TESPİTİNDE YAPAY ZEKÂ YAKLAŞIMLARI

Bu çalışmada, menkul kıymetler piyasalarında gerçekleştirilen işlem bazlı manipülasyonlar literatür incelemesi kapsamında ele alınmıştır. İşlem bazlı manipülasyon türleri ile bu türlerin gerçekleştirilmesinde kullanılan manipülatif işlem örüntüleri sistematik olarak sınıflandırıl...

Quantum Coherence in Microtubules: Brain Quantum Effects, Preliminary Evidence — E8 Intelligence Research

FINDING: Microtubule quantum coherence research suggests the brain may exploit quantum effects (e.g., superposition, entanglement) in cytoskeletal structures, but current evidence is preliminary and contested. | MATH: No closed-form equations extracted from the listed sources; ke...

A Controlled Transfer-Function Map for Symmetry-Decomposition Detectors

The parent paper argued from n=2 domains (LLM hidden states, earthquake catalogs) that a B4 isotypic componenthas no universal referent -- what each block reads is set by the data-generating process (DGP). Here we replace thetwo-domain anecdote with a controlled map: eleven stoch...

A dual-crosslinked herbal hydrogel for multimodal therapy of ulcerative colitis via IL-34/IL-22 modulation

Ulcerative colitis (UC) represents a prevalent idiopathic inflammatory disease characterized by impaired mucosal repair, gut microbiotal dysbiosis and compromised immune function. Conventional therapeutic approaches predominantly focus on symptom management, frequently resulting...

Antibacterial Activity of Achatina fulica Shell Powder against Selected Bacterial Pathogens Associated with Wound Infections

Wound infections remain a major public health concern due to the increasing prevalence of multidrug-resistant bacterial pathogens, which reduce the effectiveness of conventional antibiotics. This study evaluated the antibacterial activity of Achatina fulica shell powder against s...

Insulin Resistance and Subclinical Myocardial Dysfunction in Type 2 Diabetes: A Cross-sectional Study

Introduction: Left atrial (LA) strain and left ventricular (LV) global longitudinal strain (GLS) on two-dimensional echocardiography in asymptomatic Type 2 diabetes mellitus (T2DM) patients might help recognise subclinical myocardial dysfunction in these patients. Since T2DM is a...

Projective Dynamic Logo (PDL) — Global Mapping of Structures, Results, and Open Problems — Version 34

Version 34 of the PDL Global Mapping. This is the first version of this document to withdraw a standing claim of unconditional causal closure. Two independent gaps are now recorded on the chain from axioms C1–C4 to Newton's constant G. First, the active surface R_surf = φ·r_val/3...

Neuralese, Thinkish, and Poetry

Tracing the term "Neuralese" from its coinage in Andreas et al. (2017), where it named an emergent inter-agent protocol, to its current use for latent Chain-of-Thought reasoning, this paper examines the intermediate category that alignment research has come to call linguistic dri...

Minireview – Fruits Waste as Alternative Feed Ingredients in Aquaculture

Abstract Agricultural byproducts of fruit waste, such as banana peels, mango peels, orange peels, pomegranate peels, and pineapple peels, are sources of nutrients and bioactive compounds that have the potential to be used as raw materials for functional feed in aquaculture. This...

REASON FOR USING FREQUENCY AND PERCENTAGE TO ANALYSE CATEGORICAL DATA

Categorical data consist of information that can be classified into distinct groups, such as gender, marital status, occupation, educational level, and responses to survey questions. Frequency and percentage are commonly used descriptive statistical methods for analysing and pres...

Experimental evaluation of Nilotinib and Paclitaxel co-delivered via albumin nanoparticles as a therapeutic strategy for lung squamous cell carcinoma

Chemotherapy remains the primary treatment for advanced lung squamous cell carcinoma (LUSC); however, its severe toxic side effects significantly limit therapeutic efficacy. There is an urgent clinical need to integrate molecular targeting with chemotherapy to enhance treatment o...