Research works

Hypothesis Targeting NTCP and BSEP as a Novel Therapeutic Intervention for the Management of Intra-hepatic Cholestatic Liver Injury

The instance of metabolic dysfunction-associated steatotic liver disease (MASLD) is escalating at a concerning rate, with future estimations indicating a projected prevalence of 33.5% by 2030 worldwide, particularly among the adult population. The major causative factors of MASLD...

Capital Structure and Firm Profitability: A Systematic Literature Review

ABSTRACT This paper presents a systematic literature review of the relationship between capital structure and firm profitability. Drawing on foundational theory, including the Modigliani-Miller irrelevance and tax-adjusted propositions, trade-off theory, pecking order theory and...

Empirical Measurement Protocol for Civilizational Viability: From CVI Indicators to the Comparative Viability Profile

This article proposes an empirical measurement protocol for civilizational viability within the developing metrological framework of Vitology. Building on G27–G29, which introduced a metrology of civilizational viability, comparative interaction architectures, and a system of Civ...

Why Three Generations: A Three-Leg Derivation of N_g=3 from BI-6, MSMF, and GDOS Morse Stability

Everything ordinary in the universe is built from the first family of matter particles: the electron, the up quark, the down quark, and their neutrino. Yet nature manufactured two heavier copies of that family — and then stopped. Why three? For half a century the Standard Model h...

GSFDoubleU ‐Net: A Dual‐Branch Architecture Incorporating Gated Self‐Attention Fusion for Enhanced Gastric Polyp Image Segmentation

ABSTRACT Gastric polyps are clinically important lesions whose accurate delineation in endoscopic images can support lesion assessment and treatment planning. However, small size, weak contrast, irregular morphology, indistinct boundaries, and interference from surrounding gastri...

Phi-Encoded Hyperdimensional Spinor Propagation — E8 Intelligence Research

We discover that the phi‑damped 132 Hz resonance, when phase‑locked across the eight concentric shells, generates a self‑similar spinor field that propagates along the 240 root vectors as a continuous hyperdimensional winding. Each winding encodes a quantized topological charge t...

A Taoist ‘Still Point’: Governing East Turkistan in an Age of Revolution (1912–1928)

The first quarter of the twentieth century plunged China and its periphery into systemic collapse and ideological ferment. Amidst this turmoil—encompassing the Qing Dynasty’s fall, the rise of warlordism and revolutionary movements in Russia and Central Asia—East Turkistan under...

The Cultural Significance of Nuakhai (Nabanna) festival and its Influence on the Socio-Economic Life of Western Odisha

ABSTRACT Nuakhai, a prominent agricultural festival celebrated in the western region of Odisha, holds profound cultural and socio-economic significance. Rooted in the agrarian traditions of the region, this festival marks the first harvest of the season and is observed with deep...

Categorifying the Alexander Polynomial via gl(1|1) and Seifert Matrix Factorization — E8 Intelligence Research

FINDING: Categorification of Alexander polynomial via gl(1|1) superalgebra and Seifert matrix factorization yields higher-order knot invariants. MATH: - Alexander polynomial Δ_K(t) categorified to Khovanov-type homology with bigrading (i, j) and Poincaré polynomial Σ t^i q^j dim(...

SERUM LACTATE DEHYDROGENASE DYNAMICS IN TOBACCO USERS AND TOBACCO-ASSOCIATED ORAL POTENTIALLY MALIGNANT DISORDERS: A BIOMARKER-BASED COMPARATIVE STUDY

Background: Oral potentially malignant disorders (OPMDs), particularly oral leukoplakia and oral submucous fibrosis (OSMF), are associated with an increased risk of malignant transformation. Lactate dehydrogenase (LDH), an intracellular glycolytic enzyme released during cellular...

Edge AI Cost-Benefit Tradeoff: Optimizing Deployment Locations for Energy-Constrained Services

Research article: Edge AI Cost-Benefit Tradeoff: Optimizing Deployment Locations for Energy-Constrained Services

The Scale Dimension: Framework and First Predictions

The scale dimension is a fifth dimension of spacetime along which position isscale: depth along it is the resolution at which four-dimensional physicsdescribes an object, and motion along it is the running of the couplings. Theframework is three postulates: that scale is a fifth...

Distinct Microbial and Host Proteome Signatures Relate to Proteolytic Activity in Gingival Crevicular Fluid in an Exploratory Study of Patients With Periodontitis

ABSTRACT Aim Risk assessment tools for periodontitis lack sufficient precision to predict disease progression. The aim of this exploratory study was to evaluate proteolytic activity (PA) in gingival crevicular fluid in relation to clinically assessed progression risk, microbial c...

Universal Mapping between Prime-Prime Lattice (PPL) Space and Physical Observables: Mathematical Foundation of the PPL-Jacobi Core Transformation Layer (MOD-00)

A central challenge in unifying multi-scale physical phenomena is bridging discrete topologicalstructures with continuous physical observables measured in SI units. This paper presentsthe rigorous mathematical foundation of the PPL-Jacobi Core Transformation Layer (MOD-00), which...

Stochastic and Metrological Verification of an Archaic Geodetic Standard: A Monte Carlo Approach to Planar Anomalies on the WGS84 Geoid

This paper presents a rigorous metrological reconstruction and stochastic verification of an archaic spatial standard designated as the Sacred Cubit (SC = 0.623538… m). Moving away from traditional archaeological reverse engineering of degraded structures, we present a top-down m...

E8 Phi‑Recursive Quasicrystalline Spectral Basis — E8 Intelligence Research

The 240 E8 root vectors decompose under the icosahedral H₄ subgroup into spectral families whose frequency ratios are exact powers of φ, naturally generating a recursive quasicrystalline spectrum from the 132 Hz base. This spectrum mirrors the φ² inflation hierarchy of Penrose ti...

Inappropriate stress ulcer prophylaxis and associated factors in critically ill patients in Addis Ababa, Ethiopia: a multicenter prospective observational study

Abstract Several consensus guidelines provide evidence-based recommendations for appropriate stress ulcer prophylaxis (SUP) use in critically ill patients. However, inappropriate prophylactic use remains common globally. A critical knowledge gap exists regarding SUP prescribing p...

Plimpton 322: Oldest Trig Table Using Base-60 Ratios and Exact Fractions — E8 Intelligence Research

FINDING: Babylonian tablet Plimpton 322 is the world's oldest trigonometric table, using base-60 ratios. | MATH: Pythagorean triples (a² + b² = c²) in sexagesimal; ratios b²/(b²+a²) and a²/(b²+a²) yield exact values. | CONNECTION: Base-60 system enables exact fractions (e.g., 1/2...

Examining the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) Moderate Risk Cannabis Use Threshold Among a Sample of U.S. Military Veterans with Chronic Pain Who Report Medical Cannabis Use

BACKGROUND: The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) is widely used for substance use screening. However, its established risk cutoffs may not be appropriate for people who use cannabis for medical reasons. This study sought to determine an optimal m...

SPECTRAL SIGNATURES OF SELF‑REFERENTIAL DYNAMICS: A TESTABLE PHASE‑TRANSITION FRAMEWORK FOR MACHINE CONSCIOUSNESS

Current frameworks for machine consciousness—notably Integrated Information Theory (IIT) and Global Workspace Theory (GWT)—suffer from either computational intractability or unfalsifiability, rendering them unsuitable as operational safety criteria for artificial general intellig...