Research works

Decomposition analysis of the disparities in depressive symptoms among middle-aged and older adults between urban and rural areas in China: adverse childhood experiences are a contributing factor

Depression is a major public health concern in China, with growing urban-rural disparities. This study aimed to examine how adverse childhood experiences (ACEs) and other factors contribute to these disparities. Data were drawn from 7979 adults aged ≥45 years from the China Healt...

Liquid Biopsy-Guided Surgical Decision-Making in Oligometastatic Non-Small Cell Lung Cancer: Toward Dynamic Risk Stratification in the Multidisciplinary Era

Oligometastatic non-small cell lung cancer (NSCLC) is defined anatomically by a threshold of five or fewer metastatic lesions across three or fewer organs. That definition is a proxy for a biological question it cannot answer: whether the metastatic process has been arrested at a...

A Modular Peptide Strategy for Targeted Lysosomal Degradation of TGF-βR1

Abstract Direct depletion of TGF-βR1 may provide more durable suppression of profibrotic signaling than occupancy-driven inhibition, but compact lysosome-directed degraders remain underdeveloped. Here, we report a peptide-based strategy for lysosomal degradation of TGF-βR1 by re-...

Integrated Biorefineries for Food Waste and Food-Processing Side Streams Through Feedstock-Oriented Design and Sustainable Process Integration

Food waste represents a renewable carbon resource with considerable potential for the production of bioenergy, platform chemicals, biomaterials, and other high-value products within integrated biorefinery systems. However, the heterogeneous composition of food waste, together wit...

Privileged precarity: Working freelance in the TV industry

Despite growing interest in the television industry’s freelance labour market, little is yet known about how workers interpret and manage the instability, intermittent employment and organisational ambivalence that characterise these skilled contingent careers. This article inves...

Geometry vs Binary: Quantum Physics Puzzles — quantum entanglement geometry visualization failur — E8 Intelligence Research

## Binary Failure → Geometry Solution **Analysis of Findings:** The search results reveal a critical tension: quantum machine learning (QML) researchers are using neural networks to *predict* entanglement patterns, yet the underlying structure of entanglement is fundamentally geo...

Urban growth-induced surface thermal dynamics: an integrated deep learning assessment for Colombo, Sri Lanka

Abstract Urban growth is a major driver of land surface temperature (LST) change, yet most LST forecasting studies do not explicitly incorporate future urban expansion. To address this gap, we develop an integrated deep learning (DL) framework that couples urban growth simulation...

MIL.AVV. VI-IV ASRLARDAGI HARBIY-SIYOSIY JARAYONLARNING MARKAZIY OSIYO XALQLARI MIGRATSIYASIGA TA'SIRI MASALALARI

Ushbu maqolada mil. avv. I ming yillikda Markaziy Osiyo tarixida kuzatilgan ijtimoiy-siyosiy tarix kengroq talqin qilinadi. Xususan, makedoniyalik Aleksandr zamonida u bilan birga O‘rta Osiyo еrlariga kelgan yunonlarning avtoxton aholi bilan assimilyatsiya jarayoniga kirishishi,...

A Temporal-Spatial Balloon Universe: A New Conceptual Primitive for Gravity and a Global Cosmological Model that Dissolves the Principal Paradoxes of ΛCDM

This paper proposes a conceptual reframing of cosmology and fundamental physics grounded in two related primitives: (1) a new local primitive for gravity, understood as an invariant, extremely weak action concentrated by radial geometry rather than as curvature taken as ontologic...

Reconfigurable Floating‐Gate van der Waals Phototransistor With Asymmetric Contact Geometries for Bio‐Inspired Multi‐Stage Visual Tasks

ABSTRACT Bio‐inspired optoelectronic devices with in‐sensor neuromorphic computing capability are promising for artificial visual applications. However, the biological visual system possesses simultaneous sensing and multi‐stage processing capability through the retina and visual...

Toward clinically actionable lupus biomarkers: a roadmap for research, validation, and translation

Abstract Despite advances in lupus biomarker research, clinical translation has remained limited, leading to delayed diagnosis, imprecise disease monitoring, and trial-and-error treatment approaches. This roadmap, developed by the Lupus Research Alliance’s Biomarker Roadmap Commi...

Stabilizing Multi-Stranded Helical Supercylinders via Synergistic Effect of A- and C-Block Bidispersity in Frustrated ABC/ABC Binary Blends

Abstract Helical supercylindrical structures are one type of unique morphologies formed by “frustrated” linear ABC triblock copolymers, which exhibit more intricate geometrical features than straight cylinders. Their stabilization mechanism, especially the feasibility of stabiliz...

Cholesteric liquid crystal polymer network patterns prepared by inkjet printing of inks with a fluorinated diacrylate liquid crystal

Diacrylate liquid crystals have been widely used in fabricating cholesteric liquid crystal polymer network (CLCN) patterns through various methods. In this work, a series of laterally fluorinated diacrylate liquid crystals were synthesised using fluorinated p-hydroxybenzoic acids...

Routing to the seizure in postoperative human glioma cortex: spatio-temporal uncoupling between slow and fast extracellular neuronal activities

Abstract Background Diffuse gliomas are frequently associated with epilepsy, particularly in low-grade variants. Seizures are key events to be considered in glioma management, including during surgery. Optimizing resection of epileptic areas may affect not only postoperative epil...

Projected Impact of Predefined Reflex Testing Algorithms on Thyroid Function and Prostate-Specific Antigen Testing: A Real-World Laboratory Stewardship Study

Background/Objectives: Reflex testing may improve laboratory stewardship by limiting downstream analyses to situations in which additional testing is supported by the result of an initial test. This study evaluated the projected impact of predefined reflex testing algorithms on t...

A large-scale AI-assisted QA/QC analysis of microplastic data across human exposure pathways

Reliable exposure data is critical for determining the potential human health risks of microplastics. To date, however, exposure data are often difficult to compare and do not always meet quality criteria, limiting their suitability for risk assessment. This study aimed to provid...

Beyond Binary Rewrite Decisions: Separating Rewrite-Intensity Control from Level Prediction in a Frozen-LLM Generation-and-Selection Pipeline for Korean Easy-Read Drafting

Editors of published Korean Easy-Read documents changed 50 aligned sentences by widely varying amounts (edit distance 0.39–0.89), motivating rewrite intensity as a control variable for large language models (LLMs). We ask whether a requested intensity is realized per sentence and...

Image-Based Quantification of Amorphous Solid Dispersion Tablet Formulation Disintegration Profiles in a Custom USP-2 Apparatus

Abstract Amorphous solid dispersions (ASDs) are single-phase molecular mixtures of amorphous drug and polymer designed to enhance solubility, inhibit crystallization, and improve release rate, increasing bioavailability. During dissolution, water lowers the glass-transition tempe...

The Effect of Group Voice Therapy via Telepractice on Voice Fatigue in Preschool Teachers

ABSTRACT Background Although in‐person and face‐to‐face voice therapies have been used for years in professional voice users with voice fatigue, limited research examining the outcomes of group voice therapy via telepractice is available. Aims This study investigated the effectiv...

Hidden or undetected? Quantifying the boundary between structural bias and statistical noise in peer review

Purpose Peer review shapes not only the evaluation of scientific claims but also whose work gains visibility and influence. A growing body of evidence shows that review outcomes can mirror structural inequities tied to authors' identities, language backgrounds, institutional posi...