Research works

Bioprocessing method is a critical factor for IgM oligomerization

Abstract Monoclonal immunoglobulins of subclass M pose great potential to fight diverse medical complications with high efficiency. We present a comparison of stable recombinant Chinese hamster ovary DG44 and K1 cell lines expressing IgM comprising κ-light chains and µ-heavy chai...

The Trinity Framework of Cognitive Systems: A Structured Critical Thinking Architecture for Complex Adaptive Systems

This paper proposes the Trinity Framework, a multi-layer cognitive architecture integrating six complementary mechanisms for structured critical thinking, discovery, and adaptive governance. The core Trinity consists of three cognitive engines — Unification (structural insight th...

Flow Induction Therapy for Cognitive-Communication Rehabilitation: A Clinical Framework Operationalizing the Cognitive-Communication Window of Tolerance in Adult Neurogenic Practice

Purpose. This Clinical Focus article introduces Flow Induction Therapy for Cognitive-Communication Rehabilitation (FIT), a clinical framework developed from outpatient practice with adult neurogenic patients. FIT organizes skills the speech-language pathologist already uses and d...

Cannabinoids modulate inflammatory tone and attenuate inflammatory responses in human placental explants

Abstract Background With increasing cannabis use during pregnancy, understanding how cannabinoids affect placental immune function is fundamental. The placenta maintains a regulated immune environment through innate immune pathways, including nuclear factor kappa B (NF-κB)–depend...

A liquid handling platform for standardised quantification of cell-free enzymatic activity encoded by antimicrobial resistance genes

ABSTRACT Antimicrobial resistance (AMR) is a growing global threat to human health, and rapid methods for characterising emerging antimicrobial resistance genes (ARGs) are needed. Here, we develop a semi-automated workflow using cell-free gene expression (CFE) systems to measure...

Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP)

Abstract Background Hearing loss has been reported as a major, potentially modifiable risk factor for dementia and often co-occurs with tinnitus. Both conditions are prevalent and have been linked to brain health and cognitive decline. However, evidence from studies containing th...

Evolution of sideways locomotion in crabs.

The evolutionary change in the mode of locomotion is often a major evolutionary event, triggering diversification. Sideways locomotion is a defining feature of true crabs (Brachyura) and may have contributed to their ecological success. Yet, the evolutionary origin of this unique...

CellPos: a multi-task learning framework enabling accurate spatial positioning of single-cell RNA sequencing data

Integrating spatial information at single-cell resolution is essential for understanding tissue architecture, development, and disease. Adding spatial context to the body of existing single-cell RNA sequencing data enhances their interpretability and reuse potential, but inferrin...

Politicians on board! does foreign ownership matter for corporate political activity?

Purpose The nexus between firms and political actors is increasingly complex, particularly for foreign-owned firms operating in host countries. While corporate political connections can provide local knowledge and legitimacy, potentially transforming foreign-owned firms from “out...

Leisure-time physical activity for middle-aged and older people with spinal cord injuries: beyond physical gains and individual responsibility

Abstract Study design We conducted a descriptive qualitative study. Objective To identify strategies to enhance access to and engagement in leisure-time physical activity (LTPA) for Australians aged ≥45 years of age with spinal cord injury, with the view to address the high rate...

Integrated multi-omics reveals epigenetic regulation of beef color by the HMOX2 gene

Abstract Background Among the critical quality attributes of fresh meat, color serves as the primary factor driving consumer purchase decisions. Building on our prior findings that loose housing cattle produce darker semitendinosus muscle (lower CIE L*) than do tie stalls cattle,...

Probabilistic calibration of a closed-loop cardiac electromechanical model with application to cardiac resynchronization therapy

Abstract Cardiac conduction disorders such as left bundle branch block induce ventricular dyssynchrony and increase the risk of heart failure. Cardiac resynchronization therapy (CRT) improves cardiac function in approximately 70% of patients; however, identifying the optimal paci...

Remarks on Brauer–Manin Obstruction for Weil Restrictions

Given a finite extension [Formula: see text] of number fields and a smooth quasi-projective variety [Formula: see text] over [Formula: see text], if the abelianization of [Formula: see text] is trivial, we prove that there is a natural identification between Brauer–Manin sets of...

Holographic is Hamiltonian, relatively

Abstract We show that a relative holographic energy coincides with the relative Hamiltonian energy.

Optimization of cooling power of a thermoelectric refrigerator: a unified approach

Abstract We analyze the steady-state formalism for optimizing the cooling power of a thermoelectric refrigerator (TER), unifying the endoreversible and exoreversible approximations within one framework. Although the cooling power is non-optimizable within the endoreversible model...

Identifying and Correcting Inhomogeneities in the Near‐Surface Specific Humidity Record

Abstract There are notable discrepancies between near‐surface humidity trends in observational products as compared to climate models. Here, we explore the extent to which the discrepancy can be explained by inhomogeneities in the observational record. To do so, we apply a valida...

Thermodynamics and orbital structure of anti-de Sitter black holes in Palatini-inspired nonlinear electrodynamics

Abstract We construct a consistent anti-de Sitter completion of the static and spherically symmetric black-hole solution sourced by the Palatini-inspired nonlinear electrodynamics $$Y^n$$ Y n model. Here, “Palatini-inspired” denotes exclusively a first-order formulation of the el...

What quantum computer to buy?

The phrase “buy a quantum computer” covers several completely different purchasing goals. An organization may be seeking cloud access for teaching, dedicated time for research, a local machine for hardware training, a tool to solve specific problems, or a major setup that reshape...

Integrative transcriptomic profiling reveals convergent coding and non-coding signatures in pediatric bone marrow failure syndromes

Abstract Pediatric bone marrow failure (BMF) comprises heterogeneous inherited and immune-mediated disorders, yet many cases remain genetically unclassified despite comprehensive genomic evaluation. To identify shared transcriptional features beyond protein-coding variation, we p...

A dimension-stone-specific GIS-AHP framework for regional quarry suitability screening in under-mapped Precambrian basement: application to Cameroon’s West Region, Central African Fold Belt

Abstract Dimension stone exploration in crystalline basement terrains requires spatially explicit methods that integrate geological potential with environmental, infrastructural, and regulatory constraints. This study develops a GIS-based multi-criteria decision analysis (MCDA) f...