Research works

Decoding hypoxia-driven microenvironment remodeling in bladder cancer reveals TPST1 as a key driver of metastasis

Hypoxia is a key feature of the bladder cancer tumor microenvironment, but its cellular organization, prognostic value, and functional effectors remain incompletely defined. Here, we integrated single-cell RNA sequencing, bulk transcriptomic cohorts, machine-learning modeling, im...

A Paint Library of Plastic Particles (PLoPP): a spectral library, visual key, and machine learning model for paint microplastic identification

The degradation of paint is thought to be a major pathway of microplastics to the environment. However, pollution from paint microplastics is challenging to assess due to a lack of paint-specific spectral libraries and visual keys to aid in the differentiation of paint microplast...

Psychometric properties of the Fear of Falling Scale for Older adults–Turkish version (FFSO-T): a validity and reliability study

This study aimed to adapt the Fear of Falling Scale for Older Adults (FFSO), developed by Lee and Tak (2025), into Turkish and to evaluate its validity and reliability among older adults within the Turkish cultural context. This methodological study was conducted with 278 older a...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Overcoming immune checkpoint inhibitor-mediated T-cell exhaustion with a TCR β chain-directed selective dual T-cell activator

Abstract Background Resistance to immune checkpoint inhibition (ICI) using antibodies against the PD-1/PD-L1 axis remains a significant clinical challenge. Here, we report that combination of anti-PD-1 with a bifunctional fusion molecule, anti-TCRβ-IL-2, comprised of a monovalent...

Differential Effects of Cannabidiol and Cannabigerol on Cognition, Neuroinflammation, and Blood–Brain Barrier Integrity in a Rat Model of Iron Overload

Abstract Iron is an essential micronutrient for brain development, participating in mitochondrial respiration, myelination, and neurotransmitter synthesis. However, previous studies have demonstrated that excessive iron during early postnatal life induces oxidative reactions, lea...

Thinking big in small scale: characterization of peroxidase production in Komagataella phaffii using two-compartment scale-down system

Abstract The replacement of cobalt-based siccatives in unsaturated polyester resin curing requires sustainable and scalable biocatalytic alternatives, with fungal peroxidases representing a promising option. For industrial implementation, however, robust large-scale production pr...

Research on Dynamic Task Planning for Multi-Satellite Cooperative Observation Based on MADDPG

Abstract This paper addresses the challenge of efficient task planning for multi-satellite cooperative observation in dynamic environments and proposes a dynamic task planning method based on an improved multi-agent deep deterministic policy gradient algorithm. The main contribut...

Eco-friendly flexible polyvinyl-chloride composites reinforced with brine sludge and WO 3 : structural, thermal, and radiation shielding performance

Abstract This study investigated the structural, thermal, and gamma-ray shielding performance of flexible polyvinyl chloride (PVC) composites fabricated and reinforced with tungsten oxide (WO 3 ) and brine sludge (BS). The composites were prepared with varying WO 3 content (10–30...

Intraoperative Factors Associated With Postoperative Febrile Infectious Complications Following Retrograde Intrarenal Surgery: A Propensity Score-Matched Study

Purpose: To investigate the intraoperative factors associated with postoperative febrile infectious complications following retrograde intrarenal surgery (RIRS).Materials and Methods: A total of 352 patients who underwent RIRS for renal stones between March 2017 and December 2022...

Pattern Formation on a Periodic Rectangle and the Green’s Function Potential

Abstract. Many reaction-diffusion (RD) systems exhibit spot patterns. When the domain is a periodic rectangle, many such patterns can be constructed explicitly using regular integer lattices, and moreover numerical simulations show that they are prevalent even when starting with...

Scaling multimodal learning with TouchMotion AI: a design framework for embodied Thai dance instruction in multi-disability Blind education

Traditional instruction of Thai classical dance relies heavily on contact-based physical guidance, which may limit opportunities for independent practice among visually impaired students with Multiple Compounded Disabilities (MCD). This study developed and implemented the TouchMo...

Associations of basic and decision-making health literacy skills with psychological factors related to breast cancer screening: a bayesian network analysis

Breast cancer screening is vital for early detection, yet participation among rural women remains low. Basic and decision-making health literacy skills are associated with how individuals understand and act on screening information, and this study examined how these two skills re...

Altered causality perception in Parkinson’s disease

Causality perception allows observers to infer causal relationships from dynamic visual events. A classic example is Michotte’s launching effect, in which one moving object contacts a stationary object and stops as the second object begins to move, creating the perceptual impress...

Optimizing exercise for breast cancer survivors: a randomized controlled trial of daily individualization of high-intensity online concurrent training guided by autonomic modulation

Abstract Background Breast cancer and its treatments cause physical and physiological side effects that exercise can mitigate. However, there is little evidence on the effects and feasibility of high-intensity remote supervised training. In addition, there is no evidence of the e...

Metacognitive Training for Negative Symptoms (MCT-Minus) in schizophrenia: study protocol for a pragmatic randomized controlled trial

Abstract Background Negative symptoms are experienced by up to 60% of the individuals with schizophrenia and represent a stronger indicator of current and future functioning than positive symptoms. These symptoms respond poorly to pharmacological and existing psychosocial interve...

Effects of bone-quality configuration, effective peri-implant interface stiffness, and loading configuration on stress distribution in an ultrashort implant system: a three-dimensional finite element analysis

Abstract Background Ultrashort implants may reduce vertical augmentation needs when residual bone height is limited, but reduced intraosseous support may increase sensitivity to eccentric loading. This full-factorial study evaluated the effects of bone-quality configuration, effe...

THE EXPERIENCES OF BREASTFEEDING MOTHERS WITH ENGORGED BREASTS IN SELECTED CLINICS OF VHEMBE DISTRICT, LIMPOPO PROVINCE: A SYSTEMATIC LITERATUR REVIEW

Breastfeeding is widely recognized as the optimal method of infant feeding due to its nutritional, immunological, developmental, and maternal health benefits. Despite these advantages, many mothers experience breastfeeding-related complications, particularly breast engorgement, n...

Treatment-dependent and independent prognostic value of inflammation-based nutritional indices in immune checkpoint inhibitor-based therapy for esophageal cancer

Abstract Background Phase III trials have established the efficacy of immune-based therapies for unresectable advanced or recurrent esophageal squamous cell carcinoma (ESCC). However, real-world evidence comparing regimens and clinically applicable prognostic biomarkers remains l...

Father Absence and Masculinity Formation Among Young Men: A Public Practical Theological Exploration of Emotional Development and Relational Identity

Background The lack of a father figure poses a significant challenge not only for society but also for how boys form their own identity through emotion and personal growth. While there has been a large amount of research published on how boys form masculinity based on behaviour a...